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On the Role of Theory and Modeling in Neuroscience

Publikováno v: Journal of Neuroscience, 43(7), 1074-1088. Society for Neuroscience

In recent years, the field of neuroscience has gone through rapid experimental advances and extensive use of quantitative and computational methods. This accelerating growth has created a need for methodological analysis of the role of theory and the

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a387b9952e2374f9e98a8d2dfc774fd8
https://doi.org/10.1523/jneurosci.1179-22.2022

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Supplementary Data from Deep Learning Based on Standard H&E Images of Primary Melanoma Tumors Identifies Patients at Risk for Visceral Recurrence and Death

Supplementary Data from Deep Learning Based on Standard H&E Images of Primary Melanoma Tumors Identifies Patients at Risk for Visceral Recurrence and Death

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1119bebcd3df4ef630b4736ce23f3e49
https://doi.org/10.1158/1078-0432.22473240

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Data from Deep Learning Based on Standard H&E Images of Primary Melanoma Tumors Identifies Patients at Risk for Visceral Recurrence and Death

Purpose:Biomarkers for disease-specific survival (DSS) in early-stage melanoma are needed to select patients for adjuvant immunotherapy and accelerate clinical trial design. We present a pathology-based computational method using a deep neural networ

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https://doi.org/10.1158/1078-0432.c.6528453

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Neural dynamics in the limbic system during male social behaviors

Autor: Zhichao Guo, Luping Yin, Takuya Osakada, Julieta Lischinsky, Jonathan Chien, Bing Dai, Ashley Urtecho, Xiaoyu Tong, Zhe S. Chen, Dayu Lin

SummarySexual and aggressive behaviors are two evolutionarily conserved social behaviors vital for an animal’s survival and reproductive success. While an increasing number of brain regions in the limbic system have been identified as functionally

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https://doi.org/10.1101/2023.03.12.532199

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Enzyme and Transporter Kinetics for CPT-11 (Irinotecan) and SN-38: An Insight on Tumor Tissue Compartment Pharmacokinetics Using PBPK

Autor: Zhuo X Wu, Martin Czejka, Mansoor Ahmed, Dong H Yang, Rafeeq Alam Khan, Zhe S Chen, Najia Mansoor, Tasneem Ahmad, Yingfang Fan, Syed Sharib

Publikováno v: Recent Patents on Anti-Cancer Drug Discovery. 14:177-186

Background:Computational tools are becoming more and more powerful and comprehensive as compared to past decades in facilitating pharmaceutical, pharmacological and clinical practice. Anticancer agents are used either as monotherapy or in combination

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https://doi.org/10.2174/1574892814666190212164356

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From Antimicrobial to Anticancer Peptides: The Transformation of Peptides

Autor: Che G Cai, Xiao F Luo, Yuan Qin, Lu Y Feng, Zuo D Qin, Zhe S Chen, Jing Chen, Nong Y He, Ling Li, Zheng Wang, Gregory J. Duns

Publikováno v: Recent patents on anti-cancer drug discovery. 14(1)

Background: Antimicrobial peptides play an important role in the innate immune system. Possessing broad-spectrum antibacterial activity, antimicrobial peptides can quickly treat and kill various targets, including gram-negative bacteria, gram-positiv

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a311021fa928e17da7a9843077798642
https://pubmed.ncbi.nlm.nih.gov/30663573

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