Zobrazeno 1 - 10
of 59
pro vyhledávání: '"Zhe Ming Gu"'
Publikováno v:
2022 Asia-Pacific International Symposium on Electromagnetic Compatibility (APEMC).
Publikováno v:
Drug metabolism letters. 10(4)
Objective This study describes the in vivo pharmacokinetics and metabolism of [14C]labeled XQ-1H in male rats. Methods XQ-1H is a methanesulfonate of XQ, 10-O-(N,N-dimethylaminoethyl)-ginkgolide B, a derivative of ginkgolide B (GB) with enhanced wate
Publikováno v:
The Natural Products Journal. 1:135-145
Autor:
Dorota Cedzik, Zhe-ming Gu, Oscar L. Laskin, Anfan Wu, Lori Capone, Sekhar Surapaneni, Peter H. Schafer, Gondi Kumar, Kei-Lai Fong, Dennis Heller, Matthew Hoffmann, Hao Feng
Publikováno v:
Xenobiotica; the Fate of Foreign Compounds in Biological Systems
Apremilast is a novel, orally available small molecule that specifically inhibits PDE4 and thus modulates multiple pro- and anti-inflammatory mediators, and is currently under clinical development for the treatment of psoriasis and psoriatic arthriti
Autor:
Zuo Zhong, Wenming Li, Kelvin Chan, Yitao Wang, Jason M.K. Ho, Paul R. Carlier, Yifan Han, Hua Yu, Yuan Ping Pang, Zhe Ming Gu, Kelvin K.W. Kan
Publikováno v:
Journal of Pharmaceutical and Biomedical Analysis. 46:75-81
The lipophilicity and solubility profiles of bis(12)-hupyridone (B12H) and bis(7)-tacrine (B7T), two novel acetylcholinesterase inhibitors dimerized from huperzine A fragments and tacrine, respectively, were investigated over a broad pH range. Lipoph
Autor:
Yifan Han, Ge Lin, Li Zhang, Yuan Ping Pang, Jason M.K. Ho, Bobby W.H. Cheng, Hua Yu, Kelvin K.W. Kan, Kelvin Chan, Zhe Ming Gu, Yitao Wang, Wenming Li
Publikováno v:
Journal of Pharmaceutical and Biomedical Analysis. 44:1133-1138
An analytical method using on-line high performance liquid chromatography-tandem mass spectrometry with electrospray ionization was developed and applied for the quantification of bis(7)-tacrine (B7T) in rat blood. B7T and pimozide (internal standard
Publikováno v:
Rapid Communications in Mass Spectrometry. 20:2969-2972
Some compounds readily form [M+46]+ adduct ions during positive ion electrospray ionization mass spectrometry ((+)ESI-MS) analysis. These [M+46]+ ions were characterized as [M+CH3CH2NH2+H]+ by accurate mass determination. Ethylamine involved in the a
Autor:
Neil J. Lewis, Dawei Zhou, Holly A. Johnson, John Gordon, Jinn Wu, Zhe-Ming Gu, Jerry L. McLaughlin
Publikováno v:
Phytochemical Analysis. 10:32-38
A quantitative liquid chromatography/tandem mass spectrometry (LC/MS/MS) method was established for the quality control of the Annonaceous acetogenins in the extracts of the paw paw tree, Asimina triloba (L.) Dunal. (Annonaceae). A new calibration me
Publikováno v:
Bioorganic & Medicinal Chemistry. 5:1911-1916
Reversed-phase high-performance liquid chromatography (RP-HPLC) fractionation, monitored by liquid chromatography/electrospray mass spectrometry (LC/ESI-MS), led to the isolation of two new bioactive annonaceous acetogenins, rollidecin C (1) and roll
Publikováno v:
Journal of Natural Products. 59:100-108
Bioactivity-directed fractionation of the seeds of Annona muricata L. (Annonaceae) resulted in the isolation of five new compounds: cis-annonacin (1), cis-annonacin-10-one (2), cis-goniothalamicin (3), arianacin (4), and javoricin (5). Three of these