Interactions of the Immune System with Human Kidney Organoids

Autor: Anusha S. Shankar, Hector Tejeda-Mora, Zhaoyu Du, Quincy Nlandu, Virginia Palomares-Cabeza, Thierry P. P. van den Bosch, Sander S. Korevaar, Fabiany Da Costa Gonçalves, Eric M. J. Bindels, R. Kramann, Marlies E. J. Reinders, Marian C. Clahsen-van Groningen, Ewout J. Hoorn, Joost Gribnau, Carla C. Baan, Martin J. Hoogduijn

Publikováno v: Transplant International, Vol 37 (2024)

Kidney organoids are an innovative tool in transplantation research. The aim of the present study was to investigate whether kidney organoids are susceptible for allo-immune attack and whether they can be used as a model to study allo-immunity in kid

Externí odkaz: https://doaj.org/article/3cc42c074ba04f7f8e9f53cc968ab725

Human Transplant Kidneys on Normothermic Machine Perfusion Display Endocrine Activity

Autor: Hui Lin, MS, Zhaoyu Du, MS, Sarah Bouari, MS, Elsaline Rijkse, MS, Iacopo Cristoferi, MD, Anja Obser, BSc, Jan Czogalla, MD, PhD, A.H. Jan Danser, PhD, Robert C. Minnee, MD, PhD, Martin J. Hoogduijn, PhD

Publikováno v: Transplantation Direct, Vol 9, Iss 7, p e1503 (2023)

Background. Normothermic machine perfusion (NMP) is an alternative to hypothermic machine perfusion (HMP) for donor kidney preservation before transplantation. Contrary to HMP, NMP allows for functional assessment of donor kidneys because normothermi

Externí odkaz: https://doaj.org/article/3758aa66115d4e74b3684c8194e3de36

p57 Suppresses the Pluripotency and Proliferation of Mouse Embryonic Stem Cells by Positively Regulating p53 Activation

Autor: Na Li, Zhaoyu Du, Yunxiang Li, Wenjing Xu, Yumei Yang, Haodong Peng, Tianxiang Song, Qihua Qin, Huining Lei, Jinlian Hua

Publikováno v: Stem Cells International, Vol 2021 (2021)

Embryonic stem cells (ESCs) are pluripotent stem cells that have indefinite self-renewal capacities under appropriate culture conditions in vitro. The pluripotency maintenance and proliferation of these cells are delicately governed by the concert ef

Externí odkaz: https://doaj.org/article/1cd55df98b914ce3bfabe9c94d885c59

Vitamin D metabolism in human kidney organoids

Autor: Marian C. Clahsen-van Groningen, Carla C. Baan, Thierry P P van den Bosch, Hui Lin, Joost Gribnau, Anusha S. Shankar, Sander S. Korevaar, Hector Tejeda Mora, Sjoerd A A van den Berg, Martin J. Hoogduijn, Ewout J. Hoorn, Ronald van der Wal, Zhaoyu Du

Publikováno v: Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association-European Renal Association, 37(1), 190-193. Oxford University Press

Human kidney organoids possess early glomerular and tubular function. However, little is known about their hormone producing ability. In this report, we show that kidney organoids take up and metabolize inactive 25(OH) vitamin D (25(OH)D3). Uptake of

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7249774a4fda51fbca3967843eed8af5
https://pure.eur.nl/en/publications/2f5a94c5-2f7a-476a-8c5d-83fcba8224e4

Pulse Lengthening of the Microwave Generated by TM₀₂ Mode Ka-Band RBWO Operating With Low Guiding Magnetic Field

Autor: Ligang Zhang, Wenyuan Liu, Jun Cheng, Shuang Li, Yan Teng, Zhaoyu Du, Changhua Chen, Jiancang Su, Dongyang Wang, Lei Gao

Publikováno v: IEEE Transactions on Electron Devices. 68:3015-3020

The TM02 mode has advantage in power capacity over the fundamental TM01 mode in relativistic backward-wave oscillator (RBWO), whereas in our formal experiment, the microwave pulse seemed not as wide as we expected. In this article, the power capacity

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::370213285235a002af687bdc48319fb6
https://doi.org/10.1109/ted.2021.3074114