Zobrazeno 1 - 10
of 12
pro vyhledávání: '"Zhaoxue Yu"'
Autor:
Guangyao Wei, Jia Liu, Jie Lan, Guangyu Ji, Huize Xia, Zhiqun Zhao, Zhaoxue Yu, Rong Sun, Chuanzhao Zhang, Haiquan Lu
Publikováno v:
Genes and Diseases, Vol 10, Iss 6, Pp 2195-2198 (2023)
Externí odkaz:
https://doaj.org/article/3a88c5b551ff41c8b2ac2d8587cede5f
Publikováno v:
Cancer Research. 83:3993-3993
Acetaminophen (N-acetyl-p-aminophenol; APAP) overdose is a common cause of drug-induced acute liver injury, thereby making APAP administration a frequently used experimental model due to its highly reproducible and dose-dependent hepatoxicity. APAP-i
Publikováno v:
Cancer Research. 83:5207-5207
Severely immunodeficient mouse strains, such as B-NDG mice, lack B, T, and NK cells, and have been widely used as an in vivo model to evaluate human immune responses, including applications in immuno-oncology in recent years. However, when human peri
Publikováno v:
Cancer Research. 83:4592-4592
Angiogenesis, vascular development, vascular permeability, and embryonic hematopoiesis is partly regulated by VEGF binding to VEGFR2, which forms receptor dimers and activates downstream signaling pathways. In addition to developmental cues, VEGFR2 i
Publikováno v:
Cancer Research. 82:1652-1652
B7-H4, a member of the B7-family of immune-regulatory ligands, has emerged in recent years as a promising target for immune checkpoint therapy development. B7-family ligands bind via extracellular tandem immunoglobulin-like domains to CD28-family rec
Publikováno v:
Cancer Research. 82:1648-1648
An often rate-limiting step for cancer immunotherapy is drug development. The generation of humanized mouse models can be used to assess the clinical utility of new drugs earlier in the discovery process. Tumor-associated macrophages (TAMs) represent
Autor:
Shujin Zhang, Yanhui Nie, Jiahui Chang, Veronika Chromikova, Luke (Zhaoxue) Yu, Mari Kuraguchi
Publikováno v:
Cancer Research. 82:2089-2089
Expression of the epithelial cytokine, thymic stromal lymphopoietin (TSLP), has been observed across several barrier surfaces and plays a critical role in both physiological and pathological processes. Via T helper (Th) 2 cytokine production, TSLP ha
Autor:
Yongfei Yang, Shuzhen Cao, Jing Zhang, Zhe Shao, Xueyuan Jiang, Qingya Duan, Maopeng Tian, Sen Mei, Luke (Zhaoxue) Yu
Publikováno v:
Cancer Research. 82:2907-2907
Regulatory T Cells (Treg) inhibit effector T cell (Teff) activity in the tumor microenvironment (TME). Therefore, depletion of regulatory T cells (Treg cells) is a promising therapeutic strategy for tumor immunotherapy. Tumor necrosis factor receptor
Publikováno v:
Cancer Research. 81:497-497
In recent years, immune checkpoint inhibitors (ICIs) have revolutionized cancer treatment. However, most patients with solid cancers do not respond to the current ICIs against PD-1/PD-L1 or CTLA-4 alone. Stimulating an effective anti-tumor immune res
Publikováno v:
Cancer Research. 81:493-493
Immune checkpoint blockade targeting PD-1/PD-L1 has enjoyed tremendous success in the clinic against various advanced stage cancers, unleashing potent and durable immune-mediated control of tumors while vastly improving patient survival. However, onl