Zobrazeno 1 - 10
of 76
pro vyhledávání: '"Zhaorui Lian"'
Autor:
Shen Wang, Jianzhong Han, Jingru Huang, Khayrul Islam, Yuheng Shi, Yuyuan Zhou, Dongwook Kim, Jane Zhou, Zhaorui Lian, Yaling Liu, Jian Huang
Publikováno v:
Stem Cell Research & Therapy, Vol 15, Iss 1, Pp 1-13 (2024)
Abstract Background Hematopoietic stem cells (HSCs) and multipotent progenitors (MPPs) play a pivotal role in maintaining lifelong hematopoiesis. The distinction between stem cells and other progenitors, as well as the assessment of their functions,
Externí odkaz:
https://doaj.org/article/9a26810599fe461089853bd6591887a8
Autor:
Konstantin Golovine, Gleb Abalakov, Zhaorui Lian, Srinivas Chatla, Adam Karami, Kumaraswamy Naidu Chitrala, Jozef Madzo, Margaret Nieborowska-Skorska, Jian Huang, Tomasz Skorski
Publikováno v:
Blood Cancer Journal, Vol 13, Iss 1, Pp 1-7 (2023)
Abstract Deletion of ABL1 was detected in a cohort of hematologic malignancies carrying AML1-ETO and NUP98 fusion proteins. Abl1−/− murine hematopoietic cells transduced with AML1-ETO and NUP98-PMX1 gained proliferation advantage when compared to
Externí odkaz:
https://doaj.org/article/9b3ccc35e2f64fd183c31210d078e826
Autor:
Bac Viet Le, Paulina Podszywalow-Bartnicka, Silvia Maifrede, Katherine Sullivan-Reed, Margaret Nieborowska-Skorska, Konstantin Golovine, Juo-Chin Yao, Reza Nejati, Kathy Q. Cai, Lisa Beatrice Caruso, Julian Swatler, Michal Dabrowski, Zhaorui Lian, Peter Valent, Elisabeth M. Paietta, Ross L. Levine, Hugo F. Fernandez, Martin S. Tallman, Mark R. Litzow, Jian Huang, Grant A. Challen, Daniel Link, Italo Tempera, Mariusz A. Wasik, Katarzyna Piwocka, Tomasz Skorski
Publikováno v:
Cell Reports, Vol 33, Iss 1, Pp 108221- (2020)
Summary: Synthetic lethality triggered by PARP inhibitor (PARPi) yields promising therapeutic results. Unfortunately, tumor cells acquire PARPi resistance, which is usually associated with the restoration of homologous recombination, loss of PARP1 ex
Externí odkaz:
https://doaj.org/article/60f114cafa24497a8542aae9dc95851f
Autor:
Yuchen Wang, Hong Tian, Wenzhi Cai, Zhaorui Lian, Dheeraj Bhavanasi, Chao Wu, Tomohiko Sato, Mineo Kurokawa, Depei Wu, Li Fu, Hong Wang, Hao Shen, Dong Liang, Jian Huang
Publikováno v:
Stem Cell Research & Therapy, Vol 9, Iss 1, Pp 1-13 (2018)
Abstract Background Deciphering molecular mechanisms underlying the division of hematopoietic stem cells (HSCs) and malignant precursors would improve our understanding of the basis of stem cell-fate decisions and oncogenic transformation. Methods Us
Externí odkaz:
https://doaj.org/article/3b92b1b2780548cfb28cc2b623ce7636
Autor:
Jiugang Song, Huahong Xie, Zhaorui Lian, Guitao Yang, Rui Du, Yulei Du, Xue Zou, HaiFeng Jin, Juan Gao, Jie Liu, Daiming Fan
Publikováno v:
Neoplasia: An International Journal for Oncology Research, Vol 8, Iss 12, Pp 995-1002 (2006)
Externí odkaz:
https://doaj.org/article/98d4a8ed314a4f199fe58f3f4b4f1e52
Autor:
Zhaorui Lian, Jie Liu, Li Li, Xianxing Li, N. Lale Satiroglu Tutan, Marcy Clayton, Meng-Chao Wu, Hong-Yang Wang, Patrick Arbuthnot, Michael Kew, Mark A. Feitelson
Publikováno v:
Neoplasia: An International Journal for Oncology Research, Vol 5, Iss 3, Pp 229-244 (2003)
Hepatitis B x antigen (HBxAg) is a trans-activating protein that may be involved in hepatocarcinogenesis, although few natural effectors of HBxAg that participate in this process have been identified. To identify additional effectors, whole cell RNA
Externí odkaz:
https://doaj.org/article/a1bef10048614d7f96aaa8c7379c0aa5
Autor:
N. Lale Satiroglu Tufan, Zhaorui Lian, Jie Liu, Jingbo Pan, Patrick Arbuthnot, Michael Kew, Marcy M. Clayton, Minghua Zhu, Mark A. Feitelson
Publikováno v:
Neoplasia: An International Journal for Oncology Research, Vol 4, Iss 4, Pp 355-368 (2002)
Hepatitis B virus encoded X antigen (HBxAg) may contribute to the development of hepatocellular carcinoma (HCC) by up-or downregulating the expression of cellular genes that promote cell growth and survival. To test this hypothesis, HBxAg-positive an
Externí odkaz:
https://doaj.org/article/9036158e79c24c248bb35f5d43ae10fa
Publikováno v:
PLoS ONE, Vol 7, Iss 4, p e35331 (2012)
Hepatitis B virus encoded X antigen (HBx) is a trans-regulatory protein that alters the activity of selected transcription factors and cytoplasmic signal transduction pathways. HBx transcriptionally up-regulates the expression of a unique gene, URG11
Externí odkaz:
https://doaj.org/article/6509a4e80d194f5a8b3dc24b06a58155
Autor:
Huan Li, Srinivas Chatla, Xiaolei Liu, Umeshkumar Vekariya, Dongwook Kim, Matthew Walt, Zhaorui Lian, George Morton, Zijie Feng, Dan Yang, Hongjun Liu, Katherine Reed, Wayne Childers, Xiang Yu, Jozef Madzo, Kumaraswamy Naidu Chitrala, Tomasz Skorski, Jian Huang
Poly (ADP-ribose) polymerase (PARP) inhibitors represent a promising new class of agents that have demonstrated efficacy in treating various cancers, particularly those that carry BRCA1/2 mutations. The cancer associated BRCA1/2 mutations disrupt DNA
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::34b3b3e9d73c925438442bc8942e4b85
https://doi.org/10.21203/rs.3.rs-2688694/v1
https://doi.org/10.21203/rs.3.rs-2688694/v1
Autor:
Tomasz Skorski, Grant A. Challen, Neil Johnson, Katarzyna Piwocka, Italo Tempera, George S. Vassiliou, Giovanni Martinelli, Jian Huang, Mark D. Minden, Mark R. Litzow, Hugo F. Fernandez, Martin S. Tallman, Elisabeth M. Paietta, Peter Valent, Stephen M. Sykes, Georg Greiner, Giorgia Simonetti, Daniela Di Marcantonio, Ksenia Matlawska-Wasowska, Boris A. Bartholdy, Kumaraswamy N. Chitrala, Antonella Padella, Zhaorui Lian, Zachary Gazze, Lisa Beatrice Caruso, Jozef Madzo, Kelsey Keith, Michael Hulse, Joseph Nacson, Wangisa M.B. Dunuwille, Katherine Sullivan-Reed, Konstantin Golovine, Margaret Nieborowska-Skorska, Bac Viet Le, Silvia Maifrede
Somatic variants in TET2 and DNMT3A are founding mutations in hematological malignancies that affect the epigenetic regulation of DNA methylation. Mutations in both genes often co-occur with activating mutations in genes encoding oncogenic tyrosine k
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::dbb1df0a7c02d673032e64a0cd119330
https://doi.org/10.1158/0008-5472.c.6513157.v1
https://doi.org/10.1158/0008-5472.c.6513157.v1