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Akademický článek

Early transcriptional and epigenetic divergence of CD8+ T cells responding to acute versus chronic infection.

Autor: Lauren K Quezada, Wenhao Jin, Yi Chia Liu, Eleanor S Kim, Zhaoren He, Cynthia S Indralingam, Tiffani Tysl, Lara Labarta-Bajo, Ellen J Wehrens, Yeara Jo, Katelynn R Kazane, Christopher Hattori, Elina I Zuniga, Gene W Yeo, John T Chang

Publikováno v: PLoS Biology, Vol 21, Iss 1, p e3001983 (2023)

During a microbial infection, responding CD8+ T cells give rise to effector cells that provide acute host defense and memory cells that provide sustained protection. An alternative outcome is exhaustion, a state of T cell dysfunction that occurs in t

Externí odkaz: https://doaj.org/article/7b4ece8f50d847b580332c8f6b7493f7

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Tissue-resident memory CD8+ T cells possess unique transcriptional, epigenetic and functional adaptations to different tissue environments

Autor: John T. Crowl, Maximilian Heeg, Amir Ferry, J. Justin Milner, Kyla D. Omilusik, Clara Toma, Zhaoren He, John T. Chang, Ananda W. Goldrath

Publikováno v: Nat Immunol
Nature immunology, vol 23, iss 7

Tissue-resident memory T cells (T(RM) cells) provide protective immunity, but the contributions of specific tissue environments to T(RM) cell differentiation and homeostasis are not well understood. In the present study, the diversity of gene express

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::071a46f29b7678c014a5975706c2a1fe
https://doi.org/10.1038/s41590-022-01229-8

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Abstract 3967: CRISPR/Cas9 screening identified novel membrane targets sensitizing hepatocellular carcinoma cells to natural killer cell-mediated cytotoxicity

Autor: Shuo Li, Lin Han, Siyao Zhang, Guangfeng Geng, Lei Huo, Dawei Huang, Zhaoren He, Shuoran Li, Zhaoshi Jiang, James X. Rong

Publikováno v: Cancer Research. 83:3967-3967

Natural killer cells (NK) play a central role in cancer immune surveillance by directly killing cancer cells and producing pro-inflammatory cytokines to stimulate and recruit other immune cells to elaborate long-lasting anti-tumor responses. However,

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::591f4345b2a062d0192590cd2366cff4
https://doi.org/10.1158/1538-7445.am2023-3967

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Upon microbial challenge, human neutrophils undergo rapid changes in nuclear architecture and chromatin folding to orchestrate an immediate inflammatory gene program

Autor: Cornelis Murre, Victor Nizet, Yi-Na Zhu, Hanbin Lu, Zhaoren He, Takeshi Isoda, Matthew Denholtz, Simon Döhrmann

Publikováno v: Genes Dev

Differentiating neutrophils undergo large-scale changes in nuclear morphology. How such alterations in structure are established and modulated upon exposure to microbial agents is largely unknown. Here, we found that prior to encounter with bacteria,

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b593c4cf545f52b5f6c08f2e92d76730
https://doi.org/10.1101/gad.333708.119

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The long noncoding RNA Malat1 regulates CD8+ T cell differentiation by mediating epigenetic repression

Autor: Jad N. Kanbar, Shengyun Ma, Eleanor S. Kim, Nadia S. Kurd, Matthew S. Tsai, Tiffani Tysl, Christella E. Widjaja, Abigail E. Limary, Brian Yee, Zhaoren He, Yajing Hao, Xiang-Dong Fu, Gene W. Yeo, Wendy J. Huang, John T. Chang

Publikováno v: The Journal of experimental medicine. 219(6)

During an immune response to microbial infection, CD8+ T cells give rise to short-lived effector cells and memory cells that provide sustained protection. Although the transcriptional programs regulating CD8+ T cell differentiation have been extensiv

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3674a9d0332167f2a9bd2f0e800b566c
https://pubmed.ncbi.nlm.nih.gov/35593887

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Early precursors and molecular determinants of tissue-resident memory CD8 + T lymphocytes revealed by single-cell RNA sequencing

Autor: Gene W. Yeo, Brigid S. Boland, John T. Chang, Lauren K. Quezada, Christella E. Widjaja, Nadia S. Kurd, Ananda W. Goldrath, Matthew S. Tsai, Tiffani Tysl, Jad N. Kanbar, Kyla D. Omilusik, Zhaoren He, Tiani L. Louis, J. Justin Milner, Wendy Huang, Cornelis Murre, Wenhao Jin, Jocelyn G. Olvera

Publikováno v: Science Immunology. 5

During an immune response to microbial infection, CD8+ T cells give rise to distinct classes of cellular progeny that coordinately mediate clearance of the pathogen and provide long-lasting protection against reinfection, including a subset of noncir

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::ebb2f68240992d74706f36b117c713b3
https://doi.org/10.1126/sciimmunol.aaz6894

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Functional delineation of tissue-resident CD8+ T cell heterogeneity during infection and cancer

Autor: Ananda W. Goldrath, John T. Chang, Kyla D. Omilusik, Bryan McDonald, John T. Crowl, Gene W. Yeo, Quynh P. Nguyen, Christella E. Widjaja, Zhaoren He, Deborah A. Witherden, J. Justin Milner, Nadia S. Kurd, Lauren K. Quezada, Clara Toma

Unremitting defense against diverse pathogens and malignancies requires a dynamic and durable immune response. Tissue-resident memory CD8+ T cells (Trm) afford robust protection against infection and cancer progression through continuous surveillance

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::259904011082db17e6c14df948d953c4
https://doi.org/10.1101/2020.03.05.979146

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