Zobrazeno 1 - 10
of 16
pro vyhledávání: '"Zhaoqian Teng"'
Autor:
Wenliang Zhu, Boya Zhang, Mengqi Li, Fan Mo, Tingwei Mi, Yihui Wu, Zhaoqian Teng, Qi Zhou, Wei Li, Baoyang Hu
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-18 (2019)
Altered dosage of developmental regulators such as transcription factors can result in disorders, such as FOXG1 syndrome. Here, the authors demonstrate the utility of SMASh technology for modulating protein dosage by modeling FOXG1 syndrome using hum
Externí odkaz:
https://doaj.org/article/fe289d2c0c864031a37e09fb8593c020
Autor:
Menghua Wu, Da Zhang, Chunying Bi, Tingwei Mi, Wenliang Zhu, Longkuo Xia, Zhaoqian Teng, Baoyang Hu, Yihui Wu
Publikováno v:
Stem Cell Reports, Vol 11, Iss 3, Pp 635-650 (2018)
Summary: Differentiation of human pluripotent stem cells (hPSCs) into striatal medium spiny neurons (MSNs) promises a cell-based therapy for Huntington's disease. However, clinical-grade MSNs remain unavailable. Here, we developed a chemical recipe n
Externí odkaz:
https://doaj.org/article/ecad29fbf87f47ecaee6b19923d1b0d4
Autor:
Zhimin Shi, Zoe Piccus, Xiaofang Zhang, Huidi Yang, Hannah Jarrell, Yan Ding, Zhaoqian Teng, Ofer Tchernichovski, XiaoChing Li
Publikováno v:
eLife, Vol 7 (2018)
miR-9 is an evolutionarily conserved miRNA that is abundantly expressed in Area X, a basal ganglia nucleus required for vocal learning in songbirds. Here, we report that overexpression of miR-9 in Area X of juvenile zebra finches impairs developmenta
Externí odkaz:
https://doaj.org/article/ad2478da3f4e450a850f492185229100
Autor:
Rongqing Chen, Jian Zhang, Yan Wu, Dongqing Wang, Guoping Feng, Ya-Ping Tang, Zhaoqian Teng, Chu Chen
Publikováno v:
Cell Reports, Vol 2, Iss 5, Pp 1329-1339 (2012)
Alzheimer's disease (AD) is the most common cause of dementia among older people. There are no effective medications currently available to prevent and treat AD and halt disease progression. Monoacylglycerol lipase (MAGL) is the primary enzyme metabo
Externí odkaz:
https://doaj.org/article/1beb15d21846402897c039b5f76d4916
Aberrant activation of the Hedgehog (HH) signaling pathway underlines the initiation and progression of a multitude of cancers. The effectiveness of the leading drugs vismodegib (GDC-0449) and sonidegib (LDE225), both Smoothened (SMO) antagonists, is
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::137fb6a83cd70bdb0fb1c6376eacef23
https://doi.org/10.1158/0008-5472.c.6511476.v1
https://doi.org/10.1158/0008-5472.c.6511476.v1
Supplementary Figure S1. Generation and characterization of cell lines for high content screening and GLI-luciferase reporter assays. Supplementary Figure S2. A high content screening identifies compound candidates that inhibit GLI2 ciliary localizat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::614faf3a02f008ccaa44dd1f7c891b68
https://doi.org/10.1158/0008-5472.22423338.v1
https://doi.org/10.1158/0008-5472.22423338.v1
Gene-specific primers used in this paper.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::74f30e971fc0623445c9ee8c4905666f
https://doi.org/10.1158/0008-5472.22423335.v1
https://doi.org/10.1158/0008-5472.22423335.v1
Autor:
Yuanyuan Wang, Libo Su, Wenwen Wang, Jinyue Zhao, Yanyan Wang, Sihan Li, Yan Liu, Renjie Chai, Xin Li, Zhaoqian Teng, Changmei Liu, Baoyang Hu, Fen Ji, Jianwei Jiao
Publikováno v:
Cell Proliferation. 56
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::719c09f779d3a1e21144b367a59e3fe0
https://doi.org/10.1111/cpr.13447
https://doi.org/10.1111/cpr.13447
Autor:
Yanxin Li, Zhongqiu Li, Min Yang, Feiyang Wang, Yuehong Zhang, Rong Li, Qian Li, Yunxia Gong, Binhong Wang, Baoguang Fan, Chunyue Wang, Lei Chen, Hong Li, Jennie Ong, Zhaoqian Teng, Lei Jin, Yan-Ling Wang, Peng Du, Jianwei Jiao
Publikováno v:
Cell Stem Cell. 29:620-634.e6
Region-related heterogeneity and state transitions of microglia are important for brain development and neurological pathogenesis. However, regional specialization and state transition in microglia during early human CNS development remain unclear. H
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::eb1ef82738d87932189df8a75de484a4
https://doi.org/10.1016/j.stem.2022.02.004
https://doi.org/10.1016/j.stem.2022.02.004
Publikováno v:
Cancer research. 80(13)
Aberrant activation of the Hedgehog (HH) signaling pathway underlines the initiation and progression of a multitude of cancers. The effectiveness of the leading drugs vismodegib (GDC-0449) and sonidegib (LDE225), both Smoothened (SMO) antagonists, is
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::2c77d76b24dfd4271c4b0708a3d589a9
https://pubmed.ncbi.nlm.nih.gov/32371475
https://pubmed.ncbi.nlm.nih.gov/32371475