Zobrazeno 1 - 10
of 51
pro vyhledávání: '"Zhaoning Zhu"'
Autor:
Alexander Vugler, James O’connell, Mai Anh Nguyen, Dietmar Weitz, Thomas Leeuw, Elizabeth Hickford, Alexander Verbitsky, Xiaoyou Ying, Markus Rehberg, Bruce Carrington, Mark Merriman, Andrew Moss, Jean-Marie Nicolas, Phil Stanley, Sara Wright, Tim Bourne, Yann Foricher, Zhaoning Zhu, Daniel Brookings, Helen Horsley, Jag Heer, Laurent Schio, Matthias Herrmann, Srinivas Rao, Markus Kohlmann, Peter Florian
Publikováno v:
Frontiers in Pharmacology, Vol 15 (2024)
Externí odkaz:
https://doaj.org/article/7c28a2cfd57b43f5bbbad3d413464f30
Autor:
Alexander Vugler, James O’Connell, Mai Anh Nguyen, Dietmar Weitz, Thomas Leeuw, Elizabeth Hickford, Alexander Verbitsky, Xiaoyou Ying, Markus Rehberg, Bruce Carrington, Mark Merriman, Andrew Moss, Jean-Marie Nicholas, Phil Stanley, Sara Wright, Tim Bourne, Yann Foricher, Zhaoning Zhu, Daniel Brookings, Helen Horsley, Jag Heer, Laurent Schio, Matthias Herrmann, Srinivas Rao, Markus Kohlmann, Peter Florian
Publikováno v:
Frontiers in Pharmacology, Vol 13 (2022)
Tumor necrosis factor (TNF) is a pleiotropic cytokine belonging to a family of trimeric proteins with both proinflammatory and immunoregulatory functions. TNF is a key mediator in autoimmune diseases and during the last couple of decades several biol
Externí odkaz:
https://doaj.org/article/1ee03f08f53b498dba01c240aad2ca37
Autor:
Vugler, Alexander, O’Connell, James, Nguyen, Mai Anh, Weitz, Dietmar, Leeuw, Thomas, Hickford, Elizabeth, Verbitsky, Alexander, Xiaoyou Ying, Rehberg, Markus, Carrington, Bruce, Merriman, Mark, Moss, Andrew, Nicholas, Jean-Marie, Stanley, Phil, Wright, Sara, Bourne, Tim, Foricher, Yann, Zhaoning Zhu, Brookings, Daniel, Horsley, Helen
Publikováno v:
Frontiers in Pharmacology; 2024, p1-17, 17p
Autor:
Martin A. Lowe, Alvaro Cardenas, Jean-Pierre Valentin, Zhaoning Zhu, Jan Abendroth, Jose L. Castro, Reiner Class, Annie Delaunois, Renaud Fleurance, Helga Gerets, Vitalina Gryshkova, Lloyd King, Donald D. Lorimer, Malcolm MacCoss, Julian H. Rowley, Marie-Luce Rosseels, Leandro Royer, Richard D. Taylor, Melanie Wong, Oliver Zaccheo, Vishal P. Chavan, Gokul A. Ghule, Bapusaheb K. Tapkir, Jeremy N. Burrows, Maëlle Duffey, Matthias Rottmann, Sergio Wittlin, Iñigo Angulo-Barturen, María Belén Jiménez-Díaz, Josefine Striepen, Kate J. Fairhurst, Tomas Yeo, David A. Fidock, Alan F. Cowman, Paola Favuzza, Benigno Crespo-Fernandez, Francisco Javier Gamo, Daniel E. Goldberg, Dominique Soldati-Favre, Benoît Laleu, Teresa de Haro
Publikováno v:
Journal of Medicinal Chemistry. 65:14121-14143
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ec94f8ff9ea22504d996591d0d9a232d
https://doi.org/10.1021/acs.jmedchem.2c01336
https://doi.org/10.1021/acs.jmedchem.2c01336
Autor:
Mihirbaran Mandal, Maria Madeira, Rupesh P. Amin, Alexei V. Buevich, Alan Cheng, Marc Labroli, Xiaoxiang Liu, John Acton, Barbara Pio, Andrea Basso, Harry Chobanian, Grace Dong, Jamie Dropinski, Yan Guo, Zhuyan Guo, Stan Kurowski, Walter Korfmacher, Sandra Lee, Dongfang Meng, Debra Ondeyka, Zhiqiang Yang, Rumin Zhang, Huijun Wei, Zhicai Wu, Fengqi Zhang, Gordon Wollenberg, Tesfaye Biftu, William J. Greenlee, Madhu Chintala, Milana Maletic, Zhaoning Zhu
Publikováno v:
Journal of Medicinal Chemistry. 65:5575-5592
Vorapaxar is an approved drug for the reduction of thrombotic cardiovascular events in patients with a history of myocardial infarction or with peripheral arterial disease. Subsequent to the discovery of Vorapaxar, medicinal chemistry efforts were co
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::20d0e58362d38a85e8d5aef1a3cbe66a
https://doi.org/10.1021/acs.jmedchem.1c02048
https://doi.org/10.1021/acs.jmedchem.1c02048
Autor:
Mckittrick Brian A, Mihirbaran Mandal, Jared N. Cumming, Andrew Brunskill, Andrew Stamford, Hongwu Wang, Xiaoxiang Liu, Alexei V. Buevich, Robert Mazzola, Peter Orth, Zhaoning Zhu, John P. Caldwell
Publikováno v:
European Journal of Organic Chemistry. 2021:5073-5079
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::df583a27443bdf99ebdd82d44726c381
https://doi.org/10.1002/ejoc.202101056
https://doi.org/10.1002/ejoc.202101056
Autor:
Vugler, Alexander, O’connell, James, Nguyen, Mai Anh, Weitz, Dietmar, Leeuw, Thomas, Hickford, Elizabeth, Verbitsky, Alexander, Xiaoyou Ying, Rehberg, Markus, Carrington, Bruce, Merriman, Mark, Moss, Andrew, Nicolas, Jean-Marie, Stanley, Phil, Wright, Sara, Bourne, Tim, Foricher, Yann, Zhaoning Zhu, Brookings, Daniel, Horsley, Helen
Publikováno v:
Frontiers in Pharmacology; 2024, p1-2, 2p
Autor:
Lili Zhang, Li Xiao, Diane Rindgen, Mihirbaran Mandal, John P. Caldwell, Xiaoxiang Liu, Anandan Palani, Zhaoning Zhu, Alexei V. Buevich, Dmitri A. Pissarnitski, Eric M. Parker, Robert Mazzola, Lynn A. Hyde, Xianhai Huang, Mckittrick Brian A
Publikováno v:
Journal of medicinal chemistry. 63(15)
Herein, we disclose three structurally differentiated γ-secretase modulators (GSMs) based on an oxadiazine scaffold. The analogues from series I potently inhibit the generation of Aβ42 in vitro when the substituents at 3 and 4 positions of the oxad
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3c49d382e7dab42ef6f306cb076a3f72
https://pubmed.ncbi.nlm.nih.gov/32786237
https://pubmed.ncbi.nlm.nih.gov/32786237
Autor:
Hongwu Wang, Leonard Favreau, Jairam Palamanda, Xinjie Lin, Diane Rindgen, John P. Caldwell, Zhaoning Zhu, Pramila Kumari, Alexei V. Buevich, Reshma Kuvelkar, Edward C. Sherer, Andrew Stamford, Kathleen Cox, Jared N. Cumming, Diane Grotz, Matthew E. Kennedy, Xiaoxang Liu, Mihir Mandal, Lynn A. Hyde, Kaushik Mitra, Eric M. Parker, Xia Chen, Robert Mazzola
Publikováno v:
Journal of Medicinal Chemistry. 61:10700-10708
Herein we describe structure-activity relationship (SAR) and metabolite identification (Met-ID) studies that provided insight into the origin of time-dependent inhibition (TDI) of cytochrome P450 3A4 (CYP3A4) by compound 1. Collectively, these effort
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::39ff6cf8405739a6779b4176b25e3536
https://doi.org/10.1021/acs.jmedchem.8b01326
https://doi.org/10.1021/acs.jmedchem.8b01326
Autor:
Presscott T. Leach, Jared N. Cumming, Peter Orth, Yusheng Wu, Zhaoning Zhu, Xiaoxiang Liu, Guoqing Li, Kaushik Mitra, Leonard Favreau, Misiaszek Jeffrey A, Corey Strickland, Hongwu Wang, Brad E. Smith, Robert Mazzola, Diane Grotz, Xia Chen, William J. Greenlee, Mihirbaran Mandal, Michael Grzelak, Matthew E. Kennedy, Eric M. Parker, Johannes H. Voigt, John P. Caldwell, Andrew Stamford, Irina Kazakevich, Kathleen Cox, Reshma Kuvelkar, Lili Zhang, Giuseppe Terracina, Qi Zhang, Maria S. Michener, Lynn A. Hyde, Alexei V. Buevich, Mckittrick Brian A
Publikováno v:
Journal of Medicinal Chemistry. 59:3231-3248
We describe successful efforts to optimize the in vivo profile and address off-target liabilities of a series of BACE1 inhibitors represented by 6 that embodies the recently validated fused pyrrolidine iminopyrimidinone scaffold. Employing structure-
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4f0742b9d71d3862a6aedfb862312aaa
https://doi.org/10.1021/acs.jmedchem.5b01995
https://doi.org/10.1021/acs.jmedchem.5b01995