Zobrazeno 1 - 7
of 7
pro vyhledávání: '"Zhaolong Tong"'
Publikováno v:
Synlett. 2009:2188-2190
We describe a practical synthesis of (+)-9a-epi-stemoamide, which has been achieved in six steps from a,p-unsaturated gamma-butyrolactone. The main features of the current approach include a DBU-catalyzed Michael addition of nitroalkane and a reducti
Publikováno v:
Synlett. 2008:3239-3241
A propylene oxide assisted base-free Sonogashira cross-coupling reaction has been developed. The unique feature of the current protocol has extended the scope of Sonogashira reaction to some base-sensitive substrates.
Autor:
Xiaobo Su, Wei Zhao, Adrian Hall, Julie Hawkins, Ziqiang Cheng, Yasuji Matsuoka, Yun Jin, Haihua Yu, Guang Yang, Zhaolong Tong, Xiaomin Zhang, Lit-Fui Lau, John D. Elliott, Zehong Wan, Beverley Smith, Yanjiao Zhou, William L. Mitchell, Yingxia Sang, Matthew R. Johnson, Tina Li, David C. Harrison, Eric Yang, Helen Susanne Price, Jian Wang, Jia-Ning Xiang, Ishrut Hussain
Publikováno v:
Bioorganicmedicinal chemistry letters. 21(16)
SAR of a novel series of pyridine-derived γ-secretase modulators is described. Compound 5 was found to be a potent modulator in vitro, which on further profiling, was found to decrease Aβ42 and Aβ40, and maintain (or increase) the levels of total
Autor:
Zehong Wan, Adrian Hall, Yun Jin, Jia-Ning Xiang, Eric Yang, Andrew Eatherton, Beverley Smith, Guang Yang, Haihua Yu, Ju Wang, Liang Ye, Lit-Fui Lau, Ting Yang, William Mitchell, Wei Cai, Xiaomin Zhang, Yingxia Sang, Yonghui Wang, Zhaolong Tong, Ziqiang Cheng, Ishrut Hussain, John D. Elliott, Yasuji Matsuoka
Publikováno v:
Bioorganicmedicinal chemistry letters. 21(13)
SAR of a novel series of pyridazine-derived γ-secretase modulators is described. Compound 25 was found to be a potent modulator in vitro, which on further profiling, was found to decrease Aβ42 and Aβ40, and maintain the levels of total Aβ. Furthe
Publikováno v:
ChemInform. 40
A propylene oxide assisted base-free Sonogashira cross-coupling reaction has been developed. The unique feature of the current protocol has extended the scope of Sonogashira reaction to some base-sensitive substrates.
Publikováno v:
ChemInform. 39
Publikováno v:
Organic letters. 10(9)
An efficient eight-step assembly of the tetracyclic core (ABCD rings) of ent-(+)-nakadomarin A, a bioactive hexacyclic marine alkaloid, has been realized with Sonogashira coupling, platinum(II)-promoted cascade cyclizations, and saturation of a chall