Zobrazeno 1 - 10
of 45
pro vyhledávání: '"Zhaohui, Ao"'
Autor:
Tom Eyster, Xiaodan Ji, Sybille Galosy, Zhaohui Ao, Pramthesh Patel, Young Je Lee, Yuan Zhu, Alexis Parrillo
Publikováno v:
Biotechnology Progress. 38
Chinese hamster ovary (CHO) cells are by far the most important mammalian cell lines used for producing antibodies and other therapeutic proteins. It is critical to fully understand their physiological conditions during a bioprocess in order to achie
Autor:
Benjamin T. Bradley, James Leiper, Zhaohui Ao, Patrick Vallance, Douglas G. Johns, Christine Y. Ivashchenko
Publikováno v:
American Journal of Physiology-Heart and Circulatory Physiology. 298:H251-H258
Asymmetric dimethylarginine (ADMA) has been implicated in the progression of cardiovascular disease as an endogenous inhibitor of nitric oxide synthase. The regulation of dimethylarginine dimethylaminohydrolase (DDAH), the enzyme responsible for meta
Autor:
Douglas G. Johns, Bao W, Green P, Daniels Da, Nambi V. Aiyar, Behm Dj, Andrew J. Brown, Alastair Morrison, Simon J. Dowell, Zhaohui Ao, Walker Dj, Riddick M, Yue Tl, Staton Pc, Ellen M. Shapland, Stephen A. Douglas, Usman Shabon
Publikováno v:
British Journal of Pharmacology. 152:825-831
Background and purpose: Atypical cannabinoids are thought to cause vasodilatation through an as-yet unidentified ‘CBx' receptor. Recent reports suggest GPR55 is an atypical cannabinoid receptor, making it a candidate for the vasodilator ‘CBx' rec
Autor:
Lisa A. Payne, Nambi V. Aiyar, Zhaohui Ao, Douglas G. Johns, Quinn Lu, Nabil Elshourbagy, Taylor L. Graham, Bradley J. Heidrich, Stephen A. Douglas, Gerald E. Hunsberger
Publikováno v:
Biochemical and Biophysical Research Communications. 358:145-149
Dendroaspis natriuretic peptide (DNP) is a newly-described natriuretic peptide which lowers blood pressure via vasodilation. The natriuretic peptide clearance receptor (NPR-C) removes natriuretic peptides from the circulation, but whether DNP interac
Lysophosphatidylcholine induces inflammatory activation of human coronary artery smooth muscle cells
Autor:
Douglas G. Johns, Nambi Aiyar, Stephen A. Douglas, Haisong Ju, Sandhya S. Nerurkar, Jyoti Disa, Colin H. Macphee, Zhaohui Ao, Robert N. Willette
Publikováno v:
Molecular and Cellular Biochemistry. 295:113-120
Lysophosphatidylcholine (LPC) is the major bioactive lipid component of oxidized LDL, thought to be responsible for many of the inflammatory effects of oxidized LDL described in both inflammatory and endothelial cells. Inflammation-induced transforma
Autor:
W. Lu, Zhaohui Ao, Stephen A. Douglas, Alaa E. S. Abdel-Razik, Nick Ashton, Richard J. Balment, Song W, Douglas G. Johns
Publikováno v:
Kidney International. 69(8):1360-1368
Urotensin II (UII) is a potent vasoactive hormone in mammals. However, despite its well-known effects on epithelial sodium transport in fish, little is known about its actions on the mammalian kidney. The aim of this study was to determine the effect
Autor:
Alan R. Olzinski, Stephen A. Douglas, Marianne E. Eybye, Melissa H. Costell, Stephen A. Smith, Susan M. Gruver, Colin H. Macphee, Douglas G. Johns, Zhaohui Ao
Publikováno v:
Journal of Pharmacology and Experimental Therapeutics. 315:1020-1027
Increased susceptibility to atherosclerosis increases the risk of mortality in type 2 diabetic patients. Leukocyte adhesion to the endothelium is a critical step in atherogenesis. In addition to its insulin-sensitizing effects, rosiglitazone (RSG) po
Publikováno v:
Pharmacological Research. 51:463-471
Inflammation and leukocyte activation/infiltration play a major role in the initiation and progression of cardiovascular diseases including atherosclerosis and heart failure. Acute p38 mitogen-activated protein kinase (MAPK) pathway inhibition attenu
Autor:
Douglas G. Johns, Peter T. Buckley, Henry M. Sarau, Nabil Elshourbagy, James J. Foley, David J. Behm, Nambi V. Aiyar, Jyoti Disa, Zhaohui Ao, Stephen A. Douglas, Harjeet K. van-der-Keyl
Publikováno v:
Biochemical Pharmacology. 69:1069-1079
Urotensin-II (U-II), acting through its G-protein-coupled receptor, UT, is a possible contributor to hypertension. Variable functional responses to U-II, both within and between species studied to date, complicate the characterization of UT antagonis