Generalizable transcriptome-based tumor malignant level evaluation and molecular subtyping towards precision oncology

Autor: Dingxue Hu, Ziteng Zhang, Xiaoyi Liu, Youchun Wu, Yunyun An, Wanqiu Wang, Mengqi Yang, Yuqi Pan, Kun Qiao, Changzheng Du, Yu Zhao, Yan Li, Jianqiang Bao, Tao Qin, Yue Pan, Zhaohua Xia, Xin Zhao, Kun Sun

Publikováno v: Journal of Translational Medicine, Vol 22, Iss 1, Pp 1-15 (2024)

Abstract In cancer treatment, therapeutic strategies that integrate tumor-specific characteristics (i.e., precision oncology) are widely implemented to provide clinical benefits for cancer patients. Here, through in-depth integration of tumor transcr

Externí odkaz: https://doaj.org/article/d566655c44d1443c8dcde71c4ca43848

Pan-mediastinal neoplasm diagnosis via nationwide federated learning: a multicentre cohort study

Autor: Ruijie Tang, PhD, Hengrui Liang, PhD, Yuchen Guo, PhD, Zhigang Li, PhD, Zhichao Liu, MD, Xu Lin, PhD, Zeping Yan, BS, Jun Liu, PhD, Xin Xu, PhD, Wenlong Shao, PhD, Shuben Li, PhD, Wenhua Liang, ProfPhD, Wei Wang, PhD, Fei Cui, PhD, Huanghe He, PhD, Chao Yang, PhD, Long Jiang, PhD, Haixuan Wang, MD, Huai Chen, MD, Chenguang Guo, MD, Haipeng Zhang, MD, Zebin Gao, PhD, Yuwei He, PhD, Xiangru Chen, ME, Lei Zhao, PhD, Hong Yu, MD, Jian Hu, ProfPhD, Jiangang Zhao, MD, Bin Li, PhD, Ci Yin, MD, Wenjie Mao, MD, Wanli Lin, MD, Yujie Xie, MD, Jixian Liu, MD, Xiaoqiang Li, PhD, Dingwang Wu, MD, Qinghua Hou, MD, Yongbing Chen, PhD, Donglai Chen, PhD, Yuhang Xue, MD, Yi Liang, MD, Wenfang Tang, MD, Qi Wang, ProfPhD, Encheng Li, MD, Hongxu Liu, MD, Guan Wang, MD, Pingwen Yu, MD, Chun Chen, ProfPhD, Bin Zheng, PhD, Hao Chen, MD, Zhe Zhang, MD, Lunqing Wang, MD, Ailin Wang, MD, Zongqi Li, MD, Junke Fu, MD, Guangjian Zhang, MD, Jia Zhang, MD, Bohao Liu, MD, Jian Zhao, MD, Boyun Deng, MD, Yongtao Han, PhD, Xuefeng Leng, PhD, Zhiyu Li, MD, Man Zhang, MD, Changling Liu, MD, Tianhu Wang, MD, Zhilin Luo, MD, Chenglin Yang, MD, Xiaotong Guo, MD, Kai Ma, MD, Lixu Wang, MD, Wenjun Jiang, MD, Xu Han, MD, Qing Wang, MD, Kun Qiao, MD, Zhaohua Xia, MD, Shuo Zheng, MD, Chenyang Xu, MD, Jidong Peng, MD, Shilong Wu, MD, Zhifeng Zhang, MD, Haoda Huang, MD, Dazhi Pang, MD, Qiao Liu, BSN, Jinglong Li, MD, Xueru Ding, MD, Xiang Liu, MD, Liucheng Zhong, MD, Yutong Lu, MD, Feng Xu, PhD, Qionghai Dai, ProfPhD, Jianxing He, ProfPhD

Publikováno v: The Lancet: Digital Health, Vol 5, Iss 9, Pp e560-e570 (2023)

Summary: Background: Mediastinal neoplasms are typical thoracic diseases with increasing incidence in the general global population and can lead to poor prognosis. In clinical practice, the mediastinum's complex anatomic structures and intertype conf

Externí odkaz: https://doaj.org/article/4dca55b112774b0f8cd1255e5774a831

Regional differences of the sclera in the ocular hypertensive rat model induced by circumlimbal suture

Autor: Mingfang Xia, Endong Zhang, Fei Yao, Zhaohua Xia, Mingmin Zhou, Xufang Ran, Xiaobo Xia

Publikováno v: Eye and Vision, Vol 10, Iss 1, Pp 1-12 (2023)

Abstract Purpose To describe the regional differences of the sclera in ocular hypertension (OHT) models with the inappropriate extension of the ocular axis. Methods To discover the regional differences of the sclera at the early stage, OHT models wer

Externí odkaz: https://doaj.org/article/e630b0af6f10479f935b8b51ce42a253

Uniportal versus triportal video-assisted thoracic surgery in the treatment of tuberculous empyema

Autor: Zhaohua Xia, Shuo Zheng, Qinlang Shi, Haijiang Wang, Xinzhong Ning, Pilai Huang, Guohuan Wen, Ning Xiang, Mingfeng Liao, Mingfei Ma, Kun Qiao

Publikováno v: Journal of International Medical Research, Vol 51 (2023)

Objective To examine the effectiveness of decortication to treat chronic tuberculous empyema (TE) using uniport video-assisted thoracoscopic surgery (VATS) versus conventional triport VATS. Methods Data from consecutive patients with stage II or III

Externí odkaz: https://doaj.org/article/c8aae0512c0a4264bbe9cad4cf3773d8

The neuroprotective effect of melatonin in glutamate excitotoxicity of R28 cells and mouse retinal ganglion cells

Autor: Chao Wang, Yaqiong An, Zhaohua Xia, Xuezhi Zhou, Haibo Li, Shuang Song, Lexi Ding, Xiaobo Xia

Publikováno v: Frontiers in Endocrinology, Vol 13 (2022)

Glaucoma is the leading cause of irreversible blindness. The progressive degeneration of retinal ganglion cells (RGCs) is the major characteristic of glaucoma. Even though the control of intraocular pressure could delay the loss of RGCs, current clin

Externí odkaz: https://doaj.org/article/01699f35a291496dbe5b141e5c1b3db5