Zobrazeno 1 - 10
of 14
pro vyhledávání: '"Zhaohua Richard Huang"'
Autor:
Walid Kamoun, Elden Swindell, Christine Pien, Lia Luus, Jason Cain, Minh Pham, Irawati Kandela, Zhaohua Richard Huang, Suresh K. Tipparaju, Alexander Koshkaryev, Vasileios Askoxylakis, Dmitri B. Kirpotin, Troy Bloom, Mari Mino-Kenudson, James D. Marks, Alena Zalutskaya, Wiam Bshara, Carl Morrison, Daryl C. Drummond
Publikováno v:
Pharmaceutics, Vol 12, Iss 10, p 996 (2020)
Ephrin receptor A2 (EphA2) is a member of the Ephrin/Eph receptor cell-to-cell signaling family of molecules, and it plays a key role in cell proliferation, differentiation, and migration. EphA2 is overexpressed in a broad range of cancers, and its e
Externí odkaz:
https://doaj.org/article/8d1191f930f84ed890aae26feb4148ee
Autor:
Dmitri B. Kirpotin, Mark E. Hayes, Charles O. Noble, Zhaohua Richard Huang, Kshitija Wani, Doug Moore, Kevin Kesper, Drew O’ Brien, Daryl C. Drummond
Publikováno v:
Journal of Pharmaceutical Sciences. 112:416-434
Therapeutics at or close to the nanoscale, such as liposomal irinotecan, offer significant promise for the treatment of solid tumors. Their potential advantage over the unencapsulated or free form of the drug is due in part to their altered biodistri
Autor:
Andrew J. Sawyer, Daryl C. Drummond, Zhaohua Richard Huang, Eric Tam, Vasileios Askoxylakis, Gang Sun, Alexander Koshkaryev, Michael Santiago, Lia Luus, James F. Sampson, Ross B. Fulton, Stephanie Grabow, James J. Suchy, Anne-Sophie Dugast, Walid S. Kamoun
Supplemental figures 1, 2, and 3 and supplemental tables 1 and 2, showing the antitumor activity of EphA2-ILS-DTXp and the pharmacokinetics in multiple murine tumor models.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cc53494c662779c87e655ae0c6423c80
https://doi.org/10.1158/1535-7163.22509429
https://doi.org/10.1158/1535-7163.22509429
Autor:
Andrew J. Sawyer, Daryl C. Drummond, Zhaohua Richard Huang, Eric Tam, Vasileios Askoxylakis, Gang Sun, Alexander Koshkaryev, Michael Santiago, Lia Luus, James F. Sampson, Ross B. Fulton, Stephanie Grabow, James J. Suchy, Anne-Sophie Dugast, Walid S. Kamoun
Combinations of chemotherapy with immunotherapy have seen recent clinical success, including two approvals of anti–PD-1/L1 agents in combination with taxane-based chemotherapy in non–small cell lung cancer and triple-negative breast cancer. Here,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::cb2072df5200a5c5f8144cbc7a5091df
https://doi.org/10.1158/1535-7163.c.6539295.v1
https://doi.org/10.1158/1535-7163.c.6539295.v1
Autor:
Navreet Dhindsa, Mainak Banerjee, Xavier Delabranche, Olivier Collange, Michel Velten, Marie-Charlotte Diringer, Alexandre Detappe, Pascal Villa, Marina C. Theodorou, Gwangseong Kim, Manon Voegelin, Victor Moyo, Vitaliy Chaban, Zhenghong Hannah Xu, Patrick Gizzi, Kaniz Khalifa, Pierre Coliat, Paul-Michel Mertes, Zhaohua Richard Huang, Valérie Sartori, Jason Defuria, Nina Laurent, Clet Niyikiza, Alexandre Bernard, Bolin Geng, Xavier Pivot, Anne Roche
Publikováno v:
Journal of Controlled Release
Current therapeutic treatments improving the impaired transportation of oxygen in acute respiratory distress syndrome (ARDS) have been found to be relevant and beneficial for the therapeutic treatment of COVID-19 patients suffering from severe respir
Autor:
Alexander Koshkaryev, Walid S. Kamoun, Gang Sun, Vasileios Askoxylakis, Lia Luus, Ross B. Fulton, James F. Sampson, Eric M. Tam, Andrew J. Sawyer, Zhaohua Richard Huang, Daryl C. Drummond, Anne-Sophie Dugast, Michael Santiago, James Suchy, Stephanie Grabow
Publikováno v:
Molecular Cancer Therapeutics. 19:270-281
Combinations of chemotherapy with immunotherapy have seen recent clinical success, including two approvals of anti–PD-1/L1 agents in combination with taxane-based chemotherapy in non–small cell lung cancer and triple-negative breast cancer. Here,
Autor:
Lia Luus, Vasileios Askoxylakis, John Wilton, Alexey Lugovskoy, Kenneth J. Olivier, Stephanie Grabow, Jaeyeon Kim, Christine Pien, Geoffrey Kuesters, Suresh K. Tipparaju, Melissa Geddie, Nancy Dumont, Mark E. Hayes, Alexander Koshkaryev, Sarah A Schihl, C. Patrick Reynolds, Rachel Blaydes, Andrew J. Sawyer, James D. Marks, Tad Kornaga, James Suchy, Charles O. Noble, Dmitri B. Kirpotin, Shinji Oyama, Neeraj Kohli, Zhaohua Richard Huang, Walid S. Kamoun, Daryl C. Drummond, Yu Zhou
Publikováno v:
Nature Biomedical Engineering. 3:264-280
Antibody-mediated tumour targeting and nanoparticle-mediated encapsulation can reduce the toxicity of antitumour drugs and improve their efficacy. Here, we describe the performance of a nanotherapeutic encapsulating a hydrolytically sensitive docetax
Autor:
Alexander Koshkaryev, Wiam Bshara, Jason E. Cain, Dmitri B. Kirpotin, Walid S. Kamoun, Elden P. Swindell, Troy Bloom, Daryl C. Drummond, Carl Morrison, Suresh K. Tipparaju, Zhaohua Richard Huang, Mari Mino-Kenudson, Minh T. Pham, Irawati Kandela, Vasileios Askoxylakis, Christine Pien, Alena Zalutskaya, Lia Luus, James D. Marks
Publikováno v:
Pharmaceutics, vol 12, iss 10
Pharmaceutics
Pharmaceutics, Vol 12, Iss 996, p 996 (2020)
Volume 12
Issue 10
Pharmaceutics
Pharmaceutics, Vol 12, Iss 996, p 996 (2020)
Volume 12
Issue 10
Ephrin receptor A2 (EphA2) is a member of the Ephrin/Eph receptor cell-to-cell signaling family of molecules, and it plays a key role in cell proliferation, differentiation, and migration. EphA2 is overexpressed in a broad range of cancers, and its e
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e7d27d2b12f3a023adf89e3b13500e33
https://escholarship.org/uc/item/8b46q0tm
https://escholarship.org/uc/item/8b46q0tm
Autor:
Suresh K. Tipparaju, Charles O. Noble, Alexander Koshkaryev, Walid S. Kamoun, Jimmy Tran, Tad Kornaga, Daryl C. Drummond, Zhaohua Richard Huang, Christine Pien, Dmitri B. Kirpotin
Publikováno v:
Journal of controlled release : official journal of the Controlled Release Society. 310
Ephrin A2 targeted immunoliposomes incorporating pH-sensitive taxane prodrugs were developed for sustained delivery of active drug to solid tumors. Here we describe the systematic formulation development and characterization of these immunoliposomes.
Autor:
Gang Sun, Zhaohua Richard Huang, Andrew J. Sawyer, Walid S. Kamoun, Sergey V. Kozin, Alexander Koshkaryev, Patrick Reynolds, Vasileios Askoxylakis, Suresh K. Tipparaju, Lia Luus, Hannah Xu, Samantha Merrigan, Dmitri B. Kirpotin, Christine S. Pien, Daryl C. Drummond
Publikováno v:
Cancer Research. 77:3096-3096
Platinum-taxane combinations are widely used to treat solid tumors either in first or later lines of therapy. While effective in many settings, platinum-taxane combinatorial regimens are limited by toxicities. We have recently developed an antibody d