Zobrazeno 1 - 10
of 31
pro vyhledávání: '"Zhaobing Ding"'
Autor:
Sun-Yee Kim, Qunxiang Ong, Yilie Liao, Zhaobing Ding, Alicia Qian Ler Tan, Ler Ting Rachel Lim, Hui Min Tan, Siew Lan Lim, Qian Yi Lee, Weiping Han
Publikováno v:
International Journal of Molecular Sciences, Vol 24, Iss 11, p 9171 (2023)
Through a comprehensive analysis of the gene expression and dependency in HCC patients and cell lines, LAT1 was identified as the top amino acid transporter candidate supporting HCC tumorigenesis. To assess the suitability of LAT1 as a HCC therapeuti
Externí odkaz:
https://doaj.org/article/f2ff6c13ff9e43c2a3169dd7f9b4e76e
Autor:
Yong Chun Chong, Tan Boon Toh, Zhiling Chan, Quy Xiao Xuan Lin, Dexter Kai Hao Thng, Lissa Hooi, Zhaobing Ding, Timothy Shuen, Han Chong Toh, Yock Young Dan, Glenn Kunnath Bonney, Lei Zhou, Pierce Chow, Yulan Wang, Touati Benoukraf, Edward Kai‐Hua Chow, Weiping Han
Publikováno v:
Hepatology Communications, Vol 4, Iss 9, Pp 1362-1381 (2020)
Tumor‐specific metabolic rewiring, acquired to confer a proliferative and survival advantage over nontransformed cells, represents a renewed focus in cancer therapy development. Hepatocellular carcinoma (HCC), a malignancy that has hitherto been re
Externí odkaz:
https://doaj.org/article/455bb7e369f34263b42da99ccb4aaa1a
Autor:
Qian Yi Lee, Michael Steckel, Pierce K. H. Chow, Timothy Shen Wai Ho, Abigail Loh, Han Chong Toh, Sylvia Gruenewald, Bruno Reversade, Nathalie Escande-Beillard, Zhaobing Ding, Weiping Han, Russell Ericksen, Simon Denil, Andrea Haegebarth
Publikováno v:
Journal of Hepatology. 72:725-735
Background & Aim Under the regulation of various oncogenic pathways, cancer cells undergo adaptive metabolic programming to maintain specific metabolic states that support their uncontrolled proliferation. As it has been difficult to directly and eff
Autor:
Qunxiang Ong, Yongzhan Nie, Mingzuo Jiang, Kaisi Zhang, Weiming Ni, Hai Bin Ruan, Raimund I. Herzog, Weiping Han, Jeong Sang Lee, Xiaoyong Yang, Kamini Singh, Xuemei Han, Robert S. Sherwin, Zhaobing Ding, Susan M. Kaech, Philip Lee, Jing Wu, Jinfeng Zhou, Min-Dian Li, Kevin Qian, Hans-Guido Wendel, John R. Yates, Bichen Zhang, Jay Prakash Singh
Publikováno v:
Oncogene
Cancer cells are known to adopt aerobic glycolysis in order to fuel tumor growth, but the molecular basis of this metabolic shift remains largely undefined. O-GlcNAcase (OGA) is an enzyme harboring O-linked β-N-acetylglucosamine (O-GlcNAc) hydrolase
Publikováno v:
Amino acids. 53(12)
Dysregulated cellular energetics has recently been recognized as a hallmark of cancer and garnered attention as a potential targeting strategy for cancer therapeutics. Cancer cells reprogram metabolic activities to meet bio-energetic, biosynthetic an
Autor:
Lei Zhou, Quy Xiao Xuan Lin, Dexter Kai Hao Thng, Edward Kai-Hua Chow, Yulan Wang, Zhiling Chan, Timothy Shuen, Weiping Han, Han Chong Toh, Yong Chun Chong, Touati Benoukraf, Yock Young Dan, Glenn Kunnath Bonney, Tan Boon Toh, Pierce K. H. Chow, Lissa Hooi, Zhaobing Ding
Publikováno v:
Hepatology Communications, Vol 4, Iss 9, Pp 1362-1381 (2020)
Hepatology Communications
Hepatology Communications
We demonstrate that in human HCCs with deregulated expression of purine metabolic enzymes, targeting purine metabolism was effective in blocking tumor cell proliferation, leading to tumor shrinkage. Precise regulation of purine metabolic activity was
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::08f69766384aab19bb1dd18cc2cc7aeb
https://hdl.handle.net/10356/144809
https://hdl.handle.net/10356/144809
Autor:
Philip Lee, Matthew D. Hirschey, Wai Ho Shuen, Russell Ericksen, Han Chong Toh, Phillip J. White, Siew Lan Lim, Eoin McDonnell, Zhaobing Ding, George K. Radda, Weiping Han, Royston Kwok, Maya Vadiveloo
Publikováno v:
Cell Metabolism. 29:1151-1165.e6
Summary Tumors display profound changes in cellular metabolism, yet how these changes aid the development and growth of tumors is not fully understood. Here we use a multi-omic approach to examine liver carcinogenesis and regeneration, and find that
Autor:
Lang Zhuo, Zhaobing Ding
Publikováno v:
Journal of Gastroenterology and Hepatology. 28:188-201
Background and Aim Hepatic fibrosis is a worldwide healthy burden associated with significant morbidity and mortality. It is caused by a variety of chronic liver injuries. There is currently no effective treatment for liver fibrosis. In this report,
Publikováno v:
Laboratory Investigation. 91:752-763
Hepatic fibrosis is the result of chronic liver injuries underlined by diverse etiologies. The massive accumulation of extracellular matrix (ECM) proteins during fibrogenesis leads to structural distortion and functional disruption of the liver. Ther
Autor:
Andrea Haegebarth, Sylvia Gruenewald, Michael Steckel, Weiping Han, Zhaobing Ding, Russell Ericksen
Publikováno v:
Cancer Research. 78:3477-3477
Cancer cells undergo dramatic metabolic reprogramming, largely to meet the requirements of sustained proliferation. These metabolic pathways are tightly regulated by various oncogenes, such as Myc and Ras. However, it has been difficult to directly a