Zobrazeno 1 - 10
of 104
pro vyhledávání: '"Zhao-peng Liu"'
Publikováno v:
Journal of Enzyme Inhibition and Medicinal Chemistry, Vol 37, Iss 1, Pp 1724-1736 (2022)
Glycogen synthase kinase 3β (GSK-3β) catalyses the hyperphosphorylation of tau protein in the Alzheimer’s disease (AD) pathology. A series of novel thieno[3,2-c]pyrazol-3-amine derivatives were designed and synthesised and evaluated as potential
Externí odkaz:
https://doaj.org/article/d213c6be82f349fd9508442953748294
Publikováno v:
Cells, Vol 9, Iss 3, p 649 (2020)
Due to the complicated pathogenesis of Alzheimer’s disease (AD), the development of multitargeted agents to simultaneously interfere with multiple pathological processes of AD is a potential choice. Glycogen synthase kinase-3β (GSK-3β) plays a vi
Externí odkaz:
https://doaj.org/article/48e13760299849e79222c447ca166761
Publikováno v:
Molecules, Vol 24, Iss 2, p 279 (2019)
To find novel antitumor agents, a series of 1H-benzofuro[3,2-c]pyrazole derivatives 4a-e were designed and synthesized. The treatment of 6-methoxybenzofuran-3(2H)-one 3 with LiHMDS in anhydrous tetrahydrofuran (THF) followed by reaction with 3-substi
Externí odkaz:
https://doaj.org/article/1b2a65d4506e4ab7a757f13a8d86401c
Publikováno v:
Acta Geotechnica. 17:5521-5532
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::edadc76ed6083d87d96634015f9e4244
https://doi.org/10.1007/s11440-022-01571-z
https://doi.org/10.1007/s11440-022-01571-z
Autor:
Zhao-Hui Wen, Meng-Meng Wang, Ling-Yun Li, Piet Herdewijn, Robert Snoeck, Graciela Andrei, Zhao-Peng Liu, Chao Liu
Publikováno v:
Bioorganic Chemistry. 135:106527
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c3213e9a9e526763adb36318672b4744
https://doi.org/10.1016/j.bioorg.2023.106527
https://doi.org/10.1016/j.bioorg.2023.106527
Publikováno v:
Current Medicinal Chemistry. 28:1585-1604
Background: The casein kinase 1 (CK1) family is involved in regulating many cellular processes, including membrane trafficking, DNA damage repair, cytoskeleton dynamics, cytoskeleton maintenance and apoptosis. CK1 isoforms, especially CK1δ and CK1ε
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b095600b3013a0cfd9fab3025cd3a866
https://doi.org/10.2174/0929867327666200713185413
https://doi.org/10.2174/0929867327666200713185413
Autor:
Chao Liu, Ying-Jie Cui, Yi-Li Yao, Cheng-Mei Zhang, Zhao-Peng Liu, Long-Qian Tang, Ya-Ting Ji, Jing-De Wu, Chen-Chen Ma
Publikováno v:
Journal of Medicinal Chemistry. 63:14840-14866
Taking the previously discovered 1-methyl-1,4-dihydroindeno[1,2c]pyrazol derivative LL01 as a lead, systematic structural modifications were made at the phenolic 6- and 7-positions and the aniline at the 3-position of the indenopyrazole core to inves
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::2238a25c4426972f655c5b833343c697
https://doi.org/10.1021/acs.jmedchem.0c01345
https://doi.org/10.1021/acs.jmedchem.0c01345
Publikováno v:
Current Medicinal Chemistry. 27:4567-4576
Background: Microtubule Targeting Agents (MTAs) represent the most successful anticancer drugs for cancer chemotherapy. Through interfering with the tubulin polymerization and depolymerization dynamics, MTAs influence intracellular transport and cell
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7ecc644dc35368f9846180a0d8d2b676
https://doi.org/10.2174/0929867327666200316144610
https://doi.org/10.2174/0929867327666200316144610
Publikováno v:
ChemMedChem. 17(6)
The epigenetic reader BRD4 is involved in chromatin remodelling and transcriptional regulation, making it a promising therapeutic target. However, over the past decades, many BRD4 inhibitors that entered clinical trials were, in the main, unsatisfact
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d5483c581cb01b87075dbc1da4da2c50
https://pubmed.ncbi.nlm.nih.gov/35146935
https://pubmed.ncbi.nlm.nih.gov/35146935
Publikováno v:
Lecture Notes in Electrical Engineering ISBN: 9789811911804
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::069d9a2bfd0defeaeddab543fa1075a5
https://doi.org/10.1007/978-981-19-1181-1_42
https://doi.org/10.1007/978-981-19-1181-1_42
