Zobrazeno 1 - 10
of 12
pro vyhledávání: '"Zhao-Zhu Zeng"'
Autor:
Donna M. Veine, Donna L. Livant, Kevin S. Fay, Zhao-Zhu Zeng, Evan D. Staszewski, Hongren Yao
Publikováno v:
Breast Cancer Research and Treatment. 125:363-375
The α5β1 integrin fibronectin receptor is an attractive therapeutic target in breast cancer because it plays key roles in invasion and metastasis. While its inactive form is widely expressed, activated α5β1 occurs only on tumor cells and their as
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d582c76442815eaf69f3a3d49aab0078
https://doi.org/10.1007/s10549-010-0826-y
https://doi.org/10.1007/s10549-010-0826-y
Autor:
Donna M. Veine, Kevin S. Fay, Evan D. Staszewski, Zhao-Zhu Zeng, Hongren Yao, Donna L. Livant
Publikováno v:
Clinical & Experimental Metastasis. 27:173-184
Activated alpha5beta1 integrin occurs specifically on tumor cells and on endothelial cells of tumor-associated vasculature, and plays a key role in invasion and metastasis. The PHSCN peptide (Ac-PHSCN-NH(2)) preferentially binds activated alpha5beta1
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8c4d0ae8ee8e818e85c82dadec8f3f79
https://doi.org/10.1007/s10585-010-9316-1
https://doi.org/10.1007/s10585-010-9316-1
Autor:
Kevin S. Fay, Aaron C. Spalding, Donna L. Livant, Korrene F. Rockwood, Sonja Markwart, Evan D. Staszewski, Hongren Yao, Zhao-Zhu Zeng
Publikováno v:
Translational Oncology. 2:8-20
Angiogenesis requires endothelial cell invasion and is crucial for wound healing and for tumor growth and metastasis. Invasion of native collagen is mediated by the alpha(5)beta(1) integrin fibronectin receptor. Thus, alpha(5)beta(1) up-regulation on
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c329fcba3a31620c1883e32cbc2b74c1
https://doi.org/10.1593/tlo.08187
https://doi.org/10.1593/tlo.08187
Autor:
Kathleen M. Woods Ignatoski, Zhao-Zhu Zeng, Yifeng Jia, Donna L. Livant, Stephen P. Ethier, Korrene F. Rockwood, Sonja Markwart
Publikováno v:
Cancer Research. 64:8674-8681
Integrins contribute to progression in many cancers, including breast cancer. For example, the interaction of alpha(5)beta(1) with plasma fibronectin causes the constitutive invasiveness of human prostate cancer cells. Inhibition of this process redu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::603cf588ccb7fb04728964505a482486
https://doi.org/10.1158/0008-5472.can-04-0069
https://doi.org/10.1158/0008-5472.can-04-0069
Autor:
Gadiparthi N. Rao, Zhao Zhu Zeng, Manjula Bhanoori, Laxmisilpa Gadiparthi, Carmen Tellez, Menashe Bar-Eli, Salil K Ghosh
Publikováno v:
Journal of Biological Chemistry. 277:21325-21331
Previously we have demonstrated that activation of p38 mitogen-activated protein kinase (MAPK) and induction of DNA synthesis in response to receptor tyrosine kinase (RTK) and G protein-coupled receptor (GPCR) agonists require NADH/NADPH-like oxidase
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3b72ef6f28bf3df384c43b9849bb8859
https://doi.org/10.1074/jbc.m201608200
https://doi.org/10.1074/jbc.m201608200
Autor:
Ying Yan, Ken Higashi, Yoichi Konishi, Ayumi Denda, Shunzo Onishi, Zhao-Zhu Zeng, Hiroshi Hiai, Shin Higashi, Hikaru Ueno
Publikováno v:
Carcinogenesis. 23:189-196
The inbred DRH rats are highly resistant to the induction of hepatocellular carcinoma (HCC) by feeding of 3'-methyl-4-dimethylaminoazobenzene (3'-Me-DAB). Previously, we found that two quantitative trait loci (QTLs), Drhl and Drh2, significantly redu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::324bde7ea4634a7ea3bdd2b7480d1e9e
https://doi.org/10.1093/carcin/23.1.189
https://doi.org/10.1093/carcin/23.1.189
Autor:
Nathan J. Hahn, Yifeng Jia, Zhao-Zhu Zeng, Korrene F. Rockwood, Donna L. Livant, Sonja Markwart
Publikováno v:
Cancer research. 66(16)
α5β1 Integrin interacts with the PHSRN sequence of plasma fibronectin, causing constitutive invasion by human prostate cancer cells. Inhibition of this process reduces tumorigenesis and prevents metastasis and recurrence. In this study, naturally s
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2b73b0c5361711ab5d47040bb599350a
https://pubmed.ncbi.nlm.nih.gov/16912186
https://pubmed.ncbi.nlm.nih.gov/16912186
Publikováno v:
The Journal of biological chemistry. 277(43)
To understand the role of eicosanoids in angiogenesis, we have studied the effect of lipoxygenase metabolites of arachidonic acid on human microvascular endothelial cell (HMVEC) DNA synthesis. Among the various lipoxygenase metabolites of arachidonic
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cfbc4a2f1b66ae9302d5972b1faf72fe
https://pubmed.ncbi.nlm.nih.gov/12193593
https://pubmed.ncbi.nlm.nih.gov/12193593
Publikováno v:
International Journal of Radiation Oncology*Biology*Physics. 72:S691-S692
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e83c66b5c376cf4af460edbf4b8d422b
https://doi.org/10.1016/j.ijrobp.2008.06.586
https://doi.org/10.1016/j.ijrobp.2008.06.586
Publikováno v:
International Journal of Radiation Oncology*Biology*Physics. 78:S645
Purpose/Objectives(s): Metastatic invasion is caused by constitutive activation of the alpha5 beta1 integrin fibronectin receptor (FnR), and is blocked by the PHSCN peptide (Ac-PHSCN-NH2) in both preclinical models and in Phase 1 clinical trial. An e
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::5e96c1f433309f34c7c814bca94030b7
https://doi.org/10.1016/j.ijrobp.2010.07.1501
https://doi.org/10.1016/j.ijrobp.2010.07.1501