Zobrazeno 1 - 10
of 24
pro vyhledávání: '"Zhao-Lin Cai"'
Autor:
Longlong Tu, Jonathan C. Bean, Yang He, Hailan Liu, Meng Yu, Hesong Liu, Nan Zhang, Na Yin, Junying Han, Nikolas A. Scarcelli, Kristine M. Conde, Mengjie Wang, Yongxiang Li, Bing Feng, Peiyu Gao, Zhao-Lin Cai, Makoto Fukuda, Mingshan Xue, Qingchun Tong, Yongjie Yang, Lan Liao, Jianming Xu, Chunmei Wang, Yanlin He, Yong Xu
Publikováno v:
The Journal of Clinical Investigation, Vol 133, Iss 14 (2023)
Glucose is the basic fuel essential for maintenance of viability and functionality of all cells. However, some neurons — namely, glucose-inhibited (GI) neurons — paradoxically increase their firing activity in low-glucose conditions and decrease
Externí odkaz:
https://doaj.org/article/db791eea21694462991bc49ae75e64ed
Autor:
Eun Ran Kim, Yuanzhong Xu, Ryan M. Cassidy, Yungang Lu, Yongjie Yang, Jinbin Tian, De-Pei Li, Rachel Van Drunen, Aleix Ribas-Latre, Zhao-Lin Cai, Mingshan Xue, Benjamin R. Arenkiel, Kristin Eckel-Mahan, Yong Xu, Qingchun Tong
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-17 (2020)
Defective rhythmic metabolism is associated with high-fat diet feeding and obesity. The authors show that the clock gene BMAL1 drives paraventricular hypothalamic neuron activity via rhythmic GABAergic neurotransmission, and that this mediates diurna
Externí odkaz:
https://doaj.org/article/b479012e40434818870fa48db8ae759a
Autor:
Wu Chen, Zhao-Lin Cai, Eugene S Chao, Hongmei Chen, Colleen M Longley, Shuang Hao, Hsiao-Tuan Chao, Joo Hyun Kim, Jessica E Messier, Huda Y Zoghbi, Jianrong Tang, John W Swann, Mingshan Xue
Publikováno v:
eLife, Vol 9 (2020)
Mutations in genes encoding synaptic proteins cause many neurodevelopmental disorders, with the majority affecting postsynaptic apparatuses and much fewer in presynaptic proteins. Syntaxin-binding protein 1 (STXBP1, also known as MUNC18-1) is an esse
Externí odkaz:
https://doaj.org/article/5451bf743be645e0ad751bf6c73b334d
Autor:
Xiqian Jiang, Jianwei Chen, Aleksandar Bajić, Chengwei Zhang, Xianzhou Song, Shaina L. Carroll, Zhao-Lin Cai, Meiling Tang, Mingshan Xue, Ninghui Cheng, Christian P. Schaaf, Feng Li, Kevin R. MacKenzie, Allan Chris M. Ferreon, Fan Xia, Meng C. Wang, Mirjana Maletić-Savatić, Jin Wang
Publikováno v:
Nature Communications, Vol 8, Iss 1, Pp 1-13 (2017)
Fluorescent sensors for small biomolecules are needed to shed insight into real-time cellular processes. Here the authors develop RealThiol, a sensor that can quantitatively monitor glutathione dynamics in living cells, and measure increased antioxid
Externí odkaz:
https://doaj.org/article/44beb87514aa4446b912f029a49d9432
Publikováno v:
eLife, Vol 7 (2018)
Light-gated chloride channels are emerging as promising optogenetic tools for inhibition of neural activity. However, their effects depend on the transmembrane chloride electrochemical gradient and may be complex due to the heterogeneity of this grad
Externí odkaz:
https://doaj.org/article/2966f28dfcaf4afd9198e5d230b89cc1
Autor:
Xiqian Jiang, Jianwei Chen, Aleksandar Bajić, Chengwei Zhang, Xianzhou Song, Shaina L. Carroll, Zhao-Lin Cai, Meiling Tang, Mingshan Xue, Ninghui Cheng, Christian P. Schaaf, Feng Li, Kevin R. MacKenzie, Allan Chris M. Ferreon, Fan Xia, Meng C. Wang, Mirjana Maletić-Savatić, Jin Wang
Publikováno v:
Nature Communications, Vol 8, Iss 1, Pp 1-1 (2017)
Nature Communications 8: Article number: 16087 (2017); Published 13 July 2017; Updated 3 October 2017. Previous work by Cho and Choi describing the development of a cyanoacrylamide-based fluorescence sensor for reversible detection of thiols in homog
Externí odkaz:
https://doaj.org/article/05dc9b0ff07143d8a1d16c74407b3307
Autor:
Colleen M. Longley, Xize Xu, Jessica E. Messier, Zhao-Lin Cai, Jung Woo Park, Hongmei Chen, Derek L. Reznik, Monika P. Jadi, Mingshan Xue
Synaptic excitation (E) and inhibition (I) stay relatively proportional to each other over different spatiotemporal scales, orchestrating neuronal activity in the brain. This proportionality, referred to as E-I balance, is thought to be critical for
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e01043eee36b74042edf89071f4acecf
https://doi.org/10.1101/2022.09.23.509267
https://doi.org/10.1101/2022.09.23.509267
Autor:
Benjamin R. Arenkiel, Zhiying Jiang, Canjun Zhu, Gang Shu, Mingshan Xue, Yuanzhong Xu, Qingchun Tong, Zhao-Lin Cai, Qingyan Jiang, Qi Wu, Yong Xu
Publikováno v:
Nature metabolism
The current obesity epidemic faces a lack of mechanistic insights. It is known that the acute activity changes of a growing number of brain neurons rapidly alter feeding behaviour; however, how these changes translate to obesity development and the f
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5358ab263ace708465c66d4181d30061
http://europepmc.org/articles/PMC7687864
http://europepmc.org/articles/PMC7687864
Autor:
Aleix Ribas-Latre, Ryan M. Cassidy, Yong Xu, Eun Ran Kim, Zhao-Lin Cai, Benjamin R. Arenkiel, Kristin Eckel-Mahan, Yongjie Yang, Jinbin Tian, De-Pei Li, Qingchun Tong, Mingshan Xue, Yungang Lu, Yuanzhong Xu, Rachel Van Drunen
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-17 (2020)
Nature Communications
Nature Communications
Defective rhythmic metabolism is associated with high-fat high-caloric diet (HFD) feeding, ageing and obesity; however, the neural basis underlying HFD effects on diurnal metabolism remains elusive. Here we show that deletion of BMAL1, a core clock g
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cce70cd7bb6dc1834a903aa16e95bbb9
https://doaj.org/article/b479012e40434818870fa48db8ae759a
https://doaj.org/article/b479012e40434818870fa48db8ae759a
Autor:
Carol A. Tamminga, Antonello Bonci, David J. Barker, Jocelyn Wu, Eric M. Parise, Leonardo Bontempi, Sissi Palma Ribeiro, Angélica Torres-Berrío, Alejandra Lopez, Marisela Morales, Marco Pignatelli, Hugo A. Tejeda, Mingshan Xue, Zhao-Lin Cai, Yocasta Alvarez-Bagnarol, Eric J. Nestler, Federica Lucantonio, Rosa Anna Maria Marino
Publikováno v:
Molecular Psychiatry
Stress promotes negative affective states, which include anhedonia and passive coping. While these features are in part mediated by neuroadaptations in brain reward circuitry, a comprehensive framework of how stress-induced negative affect may be enc
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::232a6517b07a9126d9002590b6ceb3c5
https://doi.org/10.1038/s41380-020-0686-8
https://doi.org/10.1038/s41380-020-0686-8