Zobrazeno 1 - 10
of 25
pro vyhledávání: '"Zhao Shu-Hai"'
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Publikováno v:
Organic Process Research & Development. 14:612-616
The pilot-plant syntheses of 3 and 4, the core structures of a series of P2X7 antagonists are described. The sole stereogenic center in the dihydropyridinone ring was generated by catalytic desymmetrization. Selective formylation, followed by a tande
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b8269a8ece29210dfa0d60e0ce23de97
https://doi.org/10.1021/op1000447
https://doi.org/10.1021/op1000447
Autor:
Charles Alois Dvorak, Francisco Javier Lopez-Tapia, Xiaojun Huang, Brad Loe, Debra A. Cockayne, William L. Fitch, Scott Broadbent, Berger Jacob, Christine E. Brotherton-Pleiss, Keith A. M. Walker, Rebecca Suttmann, David L. Bourdet, Lee Edwin Lowrie, Shelley K. Gleason, Dov Nitzan, Paul J. Wagner, Jiang Zhu, Zhao Shu-Hai, Fernando Padilla, André Alker, Joanie Caroon, Deborah Phippard, Alam Jahangir, Pankaj D. Rege
Publikováno v:
Journal of medicinal chemistry. 58(21)
Identification of singleton P2X7 inhibitor 1 from HTS gave a pharmacophore that eventually turned into potential clinical candidates 17 and 19. During development, a number of issues were successfully addressed, such as metabolic stability, plasma st
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9e880f027ef8eadeaef6f8cc77b4f99c
https://pubmed.ncbi.nlm.nih.gov/26460788
https://pubmed.ncbi.nlm.nih.gov/26460788
Publikováno v:
Tetrahedron Letters. 37:4463-4466
A series of arylpiperazines were synthesized in moderate to good yields by palladium-catalyzed coupling reaction of aryl halides with unprotected piperazines. Very high regioselectivities were observed when using 2-methyl or 2,6-dimethylpiperazine.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::08458fe2a35c548b2ea44ee1d47e2e95
https://doi.org/10.1016/0040-4039(96)00877-5
https://doi.org/10.1016/0040-4039(96)00877-5
Publikováno v:
Tetrahedron Letters. 37:2725-2728
A new class of tetradentate chiral picolinamide-salicylidene ligands and their corresponding manganese complexes as catalysts for epoxidation of olefins have been designed and synthesized. The manganese complexes catalyzed asymmetric epoxidation of o
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::579c57059189d91bd4d99fa196f15535
https://doi.org/10.1016/0040-4039(96)00371-1
https://doi.org/10.1016/0040-4039(96)00371-1
Publikováno v:
ChemInform. 27
A new class of tetradentate chiral picolinamide-salicylidene ligands and their corresponding manganese complexes as catalysts for epoxidation of olefins have been designed and synthesized. The manganese complexes catalyzed asymmetric epoxidation of o
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::3b37a70002085d078ce491dcd300e069
https://doi.org/10.1002/chin.199632141
https://doi.org/10.1002/chin.199632141
Publikováno v:
ChemInform. 27
A series of arylpiperazines were synthesized in moderate to good yields by palladium-catalyzed coupling reaction of aryl halides with unprotected piperazines. Very high regioselectivities were observed when using 2-methyl or 2,6-dimethylpiperazine.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::0d8e85eed5bd511ea98d65fa682a7f10
https://doi.org/10.1002/chin.199640152
https://doi.org/10.1002/chin.199640152
Akademický článek
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Autor:
Zhao, Shu-Hai, Berger, Jacob, Clark, Robin D., Sethofer, Steven G., Krauss, Nancy E., Brothers, Julie M., Martin, Renee S., Misner, Dinah L., Schwab, Dietmar, Alexandrova, Ludmila
Publikováno v:
In Bioorganic & Medicinal Chemistry Letters 2007 17(12):3504-3507
Akademický článek
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