Zobrazeno 1 - 10
of 28
pro vyhledávání: '"Zhao Qing Shen"'
Autor:
Zhao-Qing Shen, Cheng-Yen Chang, Chi-Hsiao Yeh, Chung-Kuang Lu, Hao-Chih Hung, Tai-Wen Wang, Kuan-Sheng Wu, Chien-Yi Tung, Ting-Fen Tsai
Publikováno v:
Journal of Biomedical Science, Vol 31, Iss 1, Pp 1-20 (2024)
Abstract Background CDGSH iron-sulfur domain-containing protein 2 (CISD2), a pro-longevity gene, mediates healthspan in mammals. CISD2 is down-regulated during aging. Furthermore, a persistently high level of CISD2 promotes longevity and ameliorates
Externí odkaz:
https://doaj.org/article/a234936568064c509ab7ba49f8c5352b
Autor:
Chi-Hsiao Yeh, Zhao-Qing Shen, Tai-Wen Wang, Cheng-Heng Kao, Yuan-Chi Teng, Teng-Kuang Yeh, Chung-Kuang Lu, Ting-Fen Tsai
Publikováno v:
Journal of Biomedical Science, Vol 29, Iss 1, Pp 1-21 (2022)
Abstract Background The human CISD2 gene is located within a longevity region mapped on chromosome 4q. In mice, Cisd2 levels decrease during natural aging and genetic studies have shown that a high level of Cisd2 prolongs mouse lifespan and healthspa
Externí odkaz:
https://doaj.org/article/d11df834c11b41a3ac3d234147818e8f
Autor:
Yu-Hsuan Chen, Tzu-Yu Huang, Yu-Tung Lin, Shu-Yu Lin, Wen-Hsin Li, Hsiang-Jung Hsiao, Ruei-Liang Yan, Hong-Wen Tang, Zhao-Qing Shen, Guang-Chao Chen, Kuen-Phon Wu, Ting-Fen Tsai, Ruey-Hwa Chen
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-19 (2021)
Autophagy and the ubiquitin–proteasome system (UPS) are cellular quality control processes, but their coordination remains unclear. Here, the authors show that branched ubiquitination of VPS34 functions as a switch between UPS and autophagy and has
Externí odkaz:
https://doaj.org/article/48717331846c4d5699d2e8a3c33c5192
Autor:
Chi-Chin Sun, Shao-Yun Lee, Cheng-Heng Kao, Li-Hsien Chen, Zhao-Qing Shen, Chia-Hui Lai, Tsai-Yu Tzeng, Jong-Hwei Su Pang, Wen-Tai Chiu, Ting-Fen Tsai
Publikováno v:
EBioMedicine, Vol 73, Iss , Pp 103654- (2021)
Background: Age-related changes affecting the ocular surface cause vision loss in the elderly. Cisd2 deficiency drives premature aging in mice as well as resulting in various ocular surface abnormalities. Here we investigate the role of CISD2 in corn
Externí odkaz:
https://doaj.org/article/78376f21572c42f4975d2649ef8f3641
Publikováno v:
Biomedicines, Vol 9, Iss 9, p 1229 (2021)
Cisd2 (CDGSH iron sulfur domain 2) is a pro-longevity gene that extends the lifespan and health span of mice, ameliorates age-associated structural damage and limits functional decline in multiple tissues. Non-alcoholic fatty liver disease (NAFLD), w
Externí odkaz:
https://doaj.org/article/82d0f68f104146a4b0c25a890ae522ac
Autor:
Zhao-Qing Shen, Yi-Fan Chen, Jim-Ray Chen, Yuh-Shan Jou, Pei-Chun Wu, Cheng-Heng Kao, Chih-Hao Wang, Yi-Long Huang, Chian-Feng Chen, Ting-Shuo Huang, Yu-Chiau Shyu, Shih-Feng Tsai, Lung-Sen Kao, Ting-Fen Tsai
Publikováno v:
Cell Reports, Vol 21, Iss 8, Pp 2198-2211 (2017)
CISD2 is located within the chromosome 4q region frequently deleted in hepatocellular carcinoma (HCC). Mice with Cisd2 heterozygous deficiency develop a phenotype similar to the clinical manifestation of nonalcoholic fatty liver disease (NAFLD) and n
Externí odkaz:
https://doaj.org/article/d9514aa1af2d4cba9ff02d52ab7e23ad
Autor:
Chi-Hsiao Yeh, Zhao-Qing Shen, Shao-Yu Hsiung, Pei-Chun Wu, Yuan-Chi Teng, Yi-Ju Chou, Su-Wen Fang, Chian-Feng Chen, Yu-Ting Yan, Lung-Sen Kao, Cheng-Heng Kao, Ting-Fen Tsai
Publikováno v:
PLoS Biology, Vol 17, Iss 10, p e3000508 (2019)
CDGSH iron-sulfur domain-containing protein 2 (Cisd2) is pivotal to mitochondrial integrity and intracellular Ca2+ homeostasis. In the heart of Cisd2 knockout mice, Cisd2 deficiency causes intercalated disc defects and leads to degeneration of the mi
Externí odkaz:
https://doaj.org/article/b74c01ffb5e5436ca4e8b4b9cb955d21
Publikováno v:
Antioxidants, Vol 10, Iss 4, p 559 (2021)
Nonalcoholic fatty liver disease (NAFLD) and its more severe form, nonalcoholic steatohepatitis (NASH), are the most common chronic liver diseases worldwide. However, drugs to treat NAFLD and NASH are an unmet clinical need. This study sought to prov
Externí odkaz:
https://doaj.org/article/46a95051757e462fb0dc65d327e434d5
Publikováno v:
Molecular & Cellular Oncology, Vol 5, Iss 3 (2018)
Non-alcoholic fatty liver disease (NAFLD) is the most common chronic liver disease and is the major risk factor leading to hepatocellular carcinoma (HCC). Cisd2 haploinsufficiency in mice causes NAFLD by disrupting Ca2+ homeostasis, indicating that C
Externí odkaz:
https://doaj.org/article/f1f0e311371f4ccbb87c9333729b64a1
Publikováno v:
International journal of molecular sciences. 23(22)
The aging human population with age-associated diseases has become a problem worldwide. By 2050, the global population of those who are aged 65 years and older will have tripled. In this context, delaying age-associated diseases and increasing the he
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f6650fbad868bf012ec3a1a603e9ebb4
https://pubmed.ncbi.nlm.nih.gov/36430496
https://pubmed.ncbi.nlm.nih.gov/36430496