Effects of an oral allosteric AKT inhibitor (MK-2206) on human nasopharyngeal cancer in vitro and in vivo

Autor: Zhao YY, Tian Y, Zhang J, Xu F, Yang YP, Huang Y, Zhao HY, Zhang JW, Xue C, Lam MH, Yan L, Hu ZH, Dinglin XX, Zhang L

Publikováno v: Drug Design, Development and Therapy, Vol 2014, Iss default, Pp 1827-1837 (2014)

Yuan-Yuan Zhao,1,* Ying Tian,1,* Jing Zhang,2,* Fei Xu,1 Yun-Peng Yang,1 Yan Huang,1 Hong-Yun Zhao,3 Jian-Wei Zhang,4 Cong Xue,1 Michael H Lam,5 Li Yan,5 Zhi-Huang Hu,1 Xiao-Xiao Dinglin,6 Li Zhang1,3 1Department of Medical Oncology, Sun Yat-Sen Univ

Externí odkaz: https://doaj.org/article/af776d600973407b83564a617860c10b

Enhancing Discovery of Genetic Variants for Posttraumatic Stress Disorder Through Integration of Quantitative Phenotypes and Trauma Exposure Information

Autor: Maihofer, Adam X., Choi, Karmel W., Coleman, Jonathan R.I., Daskalakis, Nikolaos P., Denckla, Christy A., Ketema, Elizabeth, Morey, Rajendra A., Polimanti, Renato, Ratanatharathorn, Andrew, Torres, Katy, Wingo, Aliza P., Zai, Clement C., Aiello, Allison E., Almli, Lynn M., Amstadter, Ananda B., Andersen, Søren B, Andreassen, Ole, Arbisi, Paul A., Ashley-Koch, Allison E., Austin, S. Bryn, Avdibegović, Esmina, Borglum, Anders D., Babić, Dragan, Bækvad-Hansen, Marie, Baker, Dewleen G., Beckham, Jean C., Bierut, Laura J., Bisson, Jonathan I., Boks, Marco P., Bolger, Elizabeth A., Bradley, Bekh, Brashear, Meghan, Breen, Gerome, Bryant, Richard, Bustamante, Angela C., Bybjerg-Grauholm, Jonas, Calabrese, Joseph R., Caldas-de-Almeida, José M., Chen, Chia-Yen, Dale, Anders, Dalvie, Shareefa, Deckert, Jürgen, Delahanty, Douglas L., Dennis, Michelle F., Disner, Seth G., Domschke, Katharina, Duncan, Laramie E., Dzubur-Kulenovic, Alma, Erbes, Christopher R., Evans, Alexandra, Farrer, Lindsay A., Feeny, Norah C., Flory, Janine D., Forbes, David, Franz, Carol E., Galea, Sandro, Garrett, Melanie E., Gautam, Aarti, Gelaye, Bizu, Gelernter, Joel, Geuze, Elbert, Gillespie, Charles F., Goçi, Aferdita, Gordon, Scott D., Guffanti, Guia, Hammamieh, Rasha, Hauser, Michael A., Heath, Andrew C., Hemmings, Sian M.J., Hougaard, David M., Jakovljević, Miro, Jett, Marti, Johnson, Eric Otto, Jones, Ian, Jovanovic, Tanja, Qin, Xue-Jun, Karstoft, Karen-Inge, Kaufman, Milissa L., Kessler, Ronald C., Khan, Alaptagin, Kimbrel, Nathan A., King, Anthony P., Koen, Nastassja, Kranzler, Henry R., Kremen, William S., Lawford, Bruce R., Lebois, Lauren A.M., Lewis, Catrin, Liberzon, Israel, Linnstaedt, Sarah D., Logue, Mark W., Lori, Adriana, Lugonja, Božo, Luykx, Jurjen J., Lyons, Michael J., Maples-Keller, Jessica L., Marmar, Charles, Martin, Nicholas G., Maurer, Douglas, Mavissakalian, Matig R., McFarlane, Alexander, McGlinchey, Regina E., McLaughlin, Katie A., McLean, Samuel A., Mehta, Divya, Mellor, Rebecca, Michopoulos, Vasiliki, Milberg, William, Miller, Mark W., Morris, Charles Phillip, Mors, Ole, Mortensen, Preben B., Nelson, Elliot C., Nordentoft, Merete, Norman, Sonya B., O'Donnell, Meaghan, Orcutt, Holly K., Panizzon, Matthew S., Peters, Edward S., Peterson, Alan L., Peverill, Matthew, Pietrzak, Robert H., Polusny, Melissa A., Rice, JP, Risbrough, Victoria B., Roberts, Andrea L., Rothbaum, Alex O., Rothbaum, Barbara O., Roy-Byrne, Peter, Ruggiero, Kenneth J., Rung, Ariane, Rutten, Bart P.F., Saccone, Nancy L., Sanchez, Sixto E., Schijven, Dick, Seedat, Soraya, Seligowski, Antonia V., Seng, Julia S., Sheerin, Christina, Silove, Derrick, Smith, Alicia K., Smoller, Jordan W., Sponheim, Scott R., Stein, Dan J., Stevens, Jennifer S., Teicher, Martin H, Thompson, Wesley K., Trapido, Edward, Uddin, Monica, Ursano, Robert J, van den Heuvel, Leigh Luella, Van Hooff, Miranda, Vermetten, Eric, Vinkers, Christiaan H., Voisey, Joanne, Wang, Yunpeng, Wang, Zhewu, Werge, Thomas, Williams, Michelle A., Williamson, Douglas E., Winternitz, Sherry, Wolf, Christiane, Wolf, Erika J., Yehuda, Rachel, Young, Keith A., Young, Ross McD., Zhao, HY, Zoellner, Lori A., Haas, Magali, Lasseter, Heather, Provost, Allison C., Salem, Rany M., Sebat, Jonathan, Shaffer, Richard A., Wu, Tianying, Ripke, Stephan, Daly, Mark J., Ressler, Kerry J., Koenen, Karestan C., Stein, Murray B., Nievergelt, Caroline M.

Publikováno v: Maihofer, Adam X. Choi, Karmel W. Coleman, Jonathan R.I. Daskalakis, Nikolaos P. Denckla, Christy A. Ketema, Elizabeth Morey, Rajendra A. Polimanti, Renato Ratanatharathorn, Andrew Torres, Katy Wingo, Aliza P. Zai, Clement C. Aiello, Allison E. Almli, Lynn M. Amstadter, Ananda B. Andersen, Søren B Andreassen, Ole Arbisi, Paul A. Ashley-Koch, Allison E. Austin, S. Bryn Avdibegović, Esmina Borglum, Anders D. Babić, Dragan Bækvad-Hansen, Marie Baker, Dewleen G. Beckham, Jean C. Bierut, Laura J. Bisson, Jonathan I. Boks, Marco P. Bolger, Elizabeth A. Bradley, Bekh Brashear, Meghan Breen, Gerome Bryant, Richard Bustamante, Angela C. Bybjerg-Grauholm, Jonas Calabrese, Joseph R. Caldas-de-Almeida, José M. Chen, Chia-Yen Dale, Anders Dalvie, Shareefa Deckert, Jürgen Delahanty, Douglas L. Dennis, Michelle F. Disner, Seth G. Domschke, Katharina Duncan, Laramie E. Dzubur-Kulenovic, Alma Erbes, Christopher R. Evans, Alexandra Farrer, Lindsay A. Feeny, Norah C. Flory, Janine D. Forbes, David Franz, Carol E. Galea, Sandro Garrett, Melanie E. Gautam, Aarti Gelaye, Bizu Gelernter, Joel Geuze, Elbert Gillespie, Charles F. Goçi, Aferdita Gordon, Scott D. Guffanti, Guia Hammamieh, Rasha Hauser, Michael A. Heath, Andrew C. Hemmings, Sian M.J. Hougaard, David M. Jakovljević, Miro Jett, Marti Johnson, Eric Otto Jones, Ian Jovanovic, Tanja Qin, Xue-Jun Karstoft, Karen-Inge Kaufman, Milissa L. Kessler, Ronald C. Khan, Alaptagin Kimbrel, Nathan A. King, Anthony P. Koen, Nastassja Kranzler, Henry R. Kremen, William S. Lawford, Bruce R. Lebois, Lauren A.M. Lewis, Catrin Liberzon, Israel Linnstaedt, Sarah D. Logue, Mark W. Lori, Adriana Lugonja, Božo Luykx, Jurjen J. Lyons, Michael J. Maples-Keller, Jessica L. Marmar, Charles Martin, Nicholas G. Maurer, Douglas Mavissakalian, Matig R. McFarlane, Alexander McGlinchey, Regina E. McLaughlin, Katie A. McLean, Samuel A. Mehta, Divya Mellor, Rebecca Michopoulos, Vasiliki Milberg, William Miller, Mark W. Morris, Charles Phillip Mors, Ole Mortensen, Preben B. Nelson, Elliot C. Nordentoft, Merete Norman, Sonya B. O'Donnell, Meaghan Orcutt, Holly K. Panizzon, Matthew S. Peters, Edward S. Peterson, Alan L. Peverill, Matthew Pietrzak, Robert H. Polusny, Melissa A. Rice, JP Risbrough, Victoria B. Roberts, Andrea L. Rothbaum, Alex O. Rothbaum, Barbara O. Roy-Byrne, Peter Ruggiero, Kenneth J. Rung, Ariane Rutten, Bart P.F. Saccone, Nancy L. Sanchez, Sixto E. Schijven, Dick Seedat, Soraya Seligowski, Antonia V. Seng, Julia S. Sheerin, Christina Silove, Derrick Smith, Alicia K. Smoller, Jordan W. Sponheim, Scott R. Stein, Dan J. Stevens, Jennifer S. Teicher, Martin H Thompson, Wesley K. Trapido, Edward Uddin, Monica Ursano, Robert J van den Heuvel, Leigh Luella Van Hooff, Miranda Vermetten, Eric Vinkers, Christiaan H. Voisey, Joanne Wang, Yunpeng Wang, Zhewu Werge, Thomas Williams, Michelle A. Williamson, Douglas E. Winternitz, Sherry Wolf, Christiane Wolf, Erika J. Yehuda, Rachel Young, Keith A. Young, Ross McD. Zhao, HY Zoellner, Lori A. Haas, Magali Lasseter, Heather Provost, Allison C. Salem, Rany M. Sebat, Jonathan Shaffer, Richard A. Wu, Tianying Ripke, Stephan Daly, Mark J. Ressler, Kerry J. Koenen, Karestan C. Stein, Murray B. Nievergelt, Caroline M. . Enhancing Discovery of Genetic Variants for Posttraumatic Stress Disorder Through Integration of Quantitative Phenotypes and Trauma Exposure Information. Biological Psychiatry. 2021, 1-11
Biological Psychiatry

Externí odkaz: http://hdl.handle.net/10852/93324
https://www.duo.uio.no/bitstream/handle/10852/93324/4/1-s2.0-S0006322321016322-main.pdf

IBD risk loci are enriched in multigenic regulatory modules encompassing putative causative genes

Autor: Momozawa, Y, Dmitrieva, J, Theatre, E, Deffontaine, V, Rahmouni, S, Charloteaux, B, Crins, F, Docampo, E, Elansary, M, Gori, AS, Lecut, C, Mariman, R, Mni, M, Oury, C, Altukhov, I, Alexeev, D, Aulchenko, Y, Amininejad, L, Bouma, G, Hoentjen, F, Lowenberg, M, Oldenburg, B, Pierik, MJ, de Jong, AE, van der Woude, C.J., Visschedijk, MC, Lathrop, M, Hugot, JP, Weersma, RK, Vos, M, Franchimont, D, Vermeire, S, Kubo, M, Louis, E, Georges, M, Abraham, C, Achkar, JP, Ahmad, T, Ananthakrishnan, AN, Andersen, V, Anderson, CA, Andrews, JM, Annese, V, Aumais, G, Baidoo, L, Baldassano, RN, Bampton, PA, Barclay, M, Barrett, JC, Bayless, TM, Bethge, J, Bitton, A, Boucher, G, Brand, S, Brandt, B, Brant, SR, Buning, C, Chew, A, Cho, JH, Cleynen, I, Cohain, A, Croft, A, Daly, MJ, D'Amato, M, Danese, S, Jong, D, Denapiene, G, Denson, LA, Devaney, KL, Dewit, O, D'Inca, R, Dubinsky, M, Duerr, RH, Edwards, C, Ellinghaus, D, Essers, J, Ferguson, LR, Festen, EA, Fleshner, P, Florin, T, Franke, A, Fransen, K, Gearry, R, Gieger, C, Glas, J, Goyette, P, Green, T, Griffiths, AM, Guthery, SL, Hakonarson, H, Halfvarson, J, Hanigan, K, Haritunians, T, de Hart, A, Hawkey, C, Hayward, NK, Hedl, M, Henderson, P, Hu, XH, Huang, HL, Hui, KY, Imielinski, M, Ippoliti, A, Jonaitis, L, Jostins, L, Karlsen, TH, Kennedy, NA, Khan, MA, Kiudelis, G, Krishnaprasad, K, Kugathasan, S, Kupcinskas, L, Latiano, A, Laukens, D, Lawrance, IC, Lee, JC, Lees, CW, Leja, M, van Limbergen, J, Lionetti, P, Liu, JZ, Mahy, G, Mansfield, J, Massey, D, Mathew, CG, McGovern, DPB, Milgrom, R, Mitrovic, M, Montgomery, GW, Mowat, C, Newman, W, Ng, A, Ng, SC, Ng, SME, Nikolaus, S, Ning, K, Nothen, M, Oikonomou, I, Palmieri, O, Parkes, M, Phillips, A, Ponsioen, CY, Potocnik, U, Prescott, NJ, Proctor, DD, Radford-Smith, G, Rahier, JF, Raychaudhuri, S, Regueiro, M, Rieder, F, Rioux, JD, Ripke, S, Roberts, R, Russell, RK, Sanderson, JD, Sans, M, Satsangi, J, Schadt, EE, Schreiber, S, Schulte, D, Schumm, LP, Scott, R, Seielstad, M, Sharma, Y, Silverberg, MS, Simms, LA, Skieceviciene, J, Spain, SL, Steinhart, AH, Stempak, JM, Stronati, L, Sventoraityte, J, Targan, SR, Taylor, KM, Velde, A, Torkvist, L, Tremelling, M, van Sommeren, S, Vasiliauskas, E, Verspaget, HW, Walters, T, Wang, K, Wang, MH, Wei, Z, Whiteman, D, Wijmenga, C, Wilson, DC, Winkelmann, J, Xavier, RJ, Zhang, B, Zhang, CK, Zhang, H, Zhang, W, Zhao, HY, Zhao, ZZ

Publikováno v: NATURE COMMUNICATIONS
Momozawa, Y, Dmitrieva, J, Théâtre, E, Deffontaine, V, Rahmouni, S, Charloteaux, B, Crins, F, Docampo, E, Elansary, M, Gori, A-S, Lecut, C, Mariman, R, Mni, M, Oury, C, Altukhov, I, Alexeev, D, Aulchenko, Y, Amininejad, L, Bouma, G, Hoentjen, F, Löwenberg, M, Oldenburg, B, Pierik, M J, Vander Meulen-de Jong, A E, Janneke van der Woude, C, Visschedijk, M C, Lathrop, M, Hugot, J-P, Weersma, R K, De Vos, M, Franchimont, D, Vermeire, S, Kubo, M & Louis, E & Georges, M 2018, ' IBD risk loci are enriched in multigenic regulatory modules encompassing putative causative genes ', Nature Communications, vol. 9, no. 1, pp. 2427 . https://doi.org/10.1038/s41467-018-04365-8
Nature Communications
Nature Communications, 9:2427. Nature Publishing Group
Nature communications, Vol. 9, no. 1, p. 2427 (2018)

GWAS have identified >200 risk loci for Inflammatory Bowel Disease (IBD). The majority of disease associations are known to be driven by regulatory variants. To identify the putative causative genes that are perturbed by these variants, we generate a

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::0dfdfd477db43cfdeff0fe3f26a98b51
https://biblio.ugent.be/publication/8582997/file/8582999

IL-2 -330T/G polymorphism and cancer risk: a meta-analysis

Autor: Zhao HY, Wang R

Publikováno v: OncoTargets and Therapy, Vol 2015, Iss default, Pp 1753-1760 (2015)

Hongyu Zhao,1,* Rui Wang2,*1Central Laboratory, The Second Affiliated Hospital of Southeast University, Nanjing, 2Nanjing Kingmed Clinical Laboratory Co., Ltd, Nanjing, Jiangsu, People’s Republic of China*These authors contributed equally to this w

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doajarticles::4c090adfca71c555498a59cdf826ab1a
http://www.dovepress.com/il-2--330tg-polymorphism-and-cancer-risk-anbspmeta-analysis-peer-reviewed-article-OTT

Clinical analysis of 50 Eastern Asian patients with primary pulmonary large-cell neuroendocrine carcinoma

Autor: Zhang XK, Qin T, Zeng YD, Zhao YY, Hou X, Fang WF, Hong SD, Zhou T, Hu ZH, Yang YP, Ma YX, Xue C, Huang Y, Zhao HY, Zhang L

Publikováno v: OncoTargets and Therapy, Vol 2015, Iss default, Pp 1219-1227 (2015)

Xin-ke Zhang,1,* Tao Qin,1,* Yin-duo Zeng,1,2,* Yuan-yuan Zhao,1 Xue Hou,1 Wen-feng Fang,1 Shao-dong Hong,1 Ting Zhou,1 Zhi-huang Hu,1 Yun-peng Yang,1 Yu-xiang Ma,1 Cong Xue,1 Yan Huang,1 Hong-yun Zhao,1 Li Zhang1 1Sun Yat-sen University Cancer Cente

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doajarticles::313608d08104736bb5c388527559ffb6
http://www.dovepress.com/clinical-analysis-of-50-eastern-asian-patients-with-primary-pulmonary--peer-reviewed-article-OTT