Zobrazeno 1 - 10
of 13
pro vyhledávání: '"Zhao B Kang"'
Autor:
Marek J Kobylarz, Jonathan M Goodwin, Zhao B Kang, John W Annand, Sarah Hevi, Ellen O'Mahony, Gregory McAllister, John Reece-Hoyes, Qiong Wang, John Alford, Carsten Russ, Alicia Lindeman, Martin Beibel, Guglielmo Roma, Walter Carbone, Judith Knehr, Joseph Loureiro, Christophe Antczak, Dmitri Wiederschain, Leon O Murphy, Suchithra Menon, Beat Nyfeler
Publikováno v:
PLoS ONE, Vol 15, Iss 8, p e0235551 (2020)
VPS34 is a key regulator of endomembrane dynamics and cargo trafficking, and is essential in cultured cell lines and in mice. To better characterize the role of VPS34 in cell growth, we performed unbiased cell line profiling studies with the selectiv
Externí odkaz:
https://doaj.org/article/405ec165a99f440886a38bc379ff0399
Autor:
Beat Nyfeler, Francesca Moretti, Ioannis Moutsatsos, Zhao B. Kang, Phil Bergman, Xian Zhang, Christophe Antczak
Publikováno v:
Scientific Reports, Vol 10, Iss 1, Pp 1-6 (2020)
Scientific Reports
Scientific Reports
Gene and compound functions are often interrogated by perturbation. However, we have limited methods to capture associated phenotypes in an unbiased and holistic manner. Here, we describe Fluopack screening as a novel platform enabling the profiling
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d5bd97cf5d454200fdedc71f6ecdd9f1
http://link.springer.com/article/10.1038/s41598-020-58861-3
http://link.springer.com/article/10.1038/s41598-020-58861-3
Autor:
Kelly Slocum, Jianmei Fan, Michael Dore, Palermo Mark G, Zhan Deng, Bakary-Barry Toure, Jorge Garcia-Fortanet, Dyuti Majumdar, Martin F. Hentemann, Nick Keen, Suzanne Zhu, Christopher Towler, Michael Shultz, William R. Sellers, Simon Mathieu, Denise Grunenfelder, Robert Koenig, Douglas C. Bauer, Shumei Liu, Jay Larrow, Victoriano Tamez, David Dunstan, Andreea Argintaru, Timothy Michael Ramsey, Zhouliang Chen, Gang Liu, Ying-Nan Chen, Rukundo Ntaganda, Bing Yu, Joanna Slisz, Hongyun Wang, Pascal D. Fortin, Christopher Sean Straub, Ji-Hu Zhang, Ping Wang, Laura R. LaBonte, Mitsunori Kato, Matthew J. Meyer, Fan Yang, Patrick James Sarver, Samuel B. Ho, Brant Firestone, Rajesh Karki, John F. Reilly, Troy Smith, Ho Man Chan, Cary Fridrich, John William Giraldes, Julie Boisclair, Chen Christine Hiu-Tung, Meir Glick, Zhao B. Kang, Morvarid Mohseni, Lawrence Blas Perez, Michael G. Acker, Sarah Williams, Matthew J. LaMarche, Martin Sendzik, Michelle Fodor, Huia-Xiang Hao, Peter Fekkes, Minying Pu, Travis Stams, Stanley Spence, Andriana Jouk
Publikováno v:
Journal of medicinal chemistry. 63(22)
SHP2 is a nonreceptor protein tyrosine phosphatase encoded by the PTPN11 gene and is involved in cell growth and differentiation via the MAPK signaling pathway. SHP2 also plays an important role in the programed cell death pathway (PD-1/PD-L1). As an
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::345804676325a445ebbb9ef600ced79a
https://pubmed.ncbi.nlm.nih.gov/32910655
https://pubmed.ncbi.nlm.nih.gov/32910655
Autor:
Matthew J. LaMarche, Peter Fekkes, Jorge Garcia Fortanet, Michael Shultz, Denise Grunenfelder, Zhouliang Chen, Gang Liu, Chen Christine Hiu-Tung, Minying Pu, Travis Stams, Pascal D. Fortin, Palermo Mark G, Ping Wang, Samuel B. Ho, Brant Firestone, Matthew J. Meyer, Dyuti Majumdar, Laura R. LaBonte, Francois Lenoir, Rajesh Karki, Nick Keen, Cary Fridrich, Michelle Fodor, Jay Larrow, Sarah Williams, Christopher Towler, Timothy Michael Ramsey, Ji-Hu Zhang, Franco Lombardo, Ying-Nan P. Chen, Zhan Deng, Mitsunori Kato, Zhao B. Kang, Lawrence Blas Perez, Shumei Liu, William R. Sellers
Publikováno v:
Journal of Medicinal Chemistry. 59:7773-7782
SHP2 is a nonreceptor protein tyrosine phosphatase (PTP) encoded by the PTPN11 gene involved in cell growth and differentiation via the MAPK signaling pathway. SHP2 also purportedly plays an important role in the programmed cell death pathway (PD-1/P
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dab8364be893583bdc1d3f32d1e22004
https://doi.org/10.1021/acs.jmedchem.6b00680
https://doi.org/10.1021/acs.jmedchem.6b00680
Autor:
Palermo Mark G, Timothy Michael Ramsey, Ping Zhu, Shumei Liu, Jay Larrow, Laura R. La Bonte, Rajesh Karki, Chen Christine Hiu-Tung, Kavitha Venkatesan, Jaison Jacob, Pascal D. Fortin, Francois Lenoir, Hui Gao, Guizhi Yang, Matthew J. Meyer, Ji-Hu Zhang, William R. Sellers, Michael Shultz, Denise Grunenfelder, Edmund Price, Jorge Garcia-Fortanet, Feng Fei, Zhouliang Chen, Gang Liu, Vesselina G. Cooke, Jing Yuan, Michelle Fodor, Ping Wang, Minying Pu, Nicholas Keen, Samuel B. Ho, Kathy Hsiao, Markus Warmuth, Travis Stams, Christopher Quinn, Mitsunori Kato, Subarna Shakya, Sarah Williams, Dyuti Majumdar, Peter Fekkes, Michael G. Acker, Cary Fridrich, Joanna Slisz, Huaixiang Hao, Matthew J. LaMarche, Ying-Nan P. Chen, Brandon Antonakos, Jason R. Dobson, Brant Firestone, Lawrence Blas Perez, Zhao B. Kang, Ho Man Chan, Zhan Deng
Publikováno v:
Nature. 535:148-152
SHP099, a selective inhibitor of signalling meditator SHP2 with drug-like properties, has an allosteric mechanism of action whereby it stabilizes SHP2 in an auto-inhibited conformation, and suppresses RAS–ERK signalling and proliferation in recepto
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f58ee0fa5f3f5109027ba2125d369122
https://doi.org/10.1038/nature18621
https://doi.org/10.1038/nature18621
Autor:
Owen Wallace, Zhao B. Kang, Jian Ding, Abhishek Dogra, Jeremy L. Jenkins, Joseph Loureiro, Christophe Antczak, Sven Schuierer, John A. Tallarico, Rishi K. Jain, Geoff Boynton, Amy Chen, Scott M. Brittain, Richard I. McDonald, Christy Fryer, Jian Shao, Frederic Sigoillot, Sara Gans, Jeffery A. Porter, Kayla Tyskiewicz, Dominic Hoepfner, Markus Schirle, Erin Nolin, Wilhelm A. Weihofen, Martin Beibel, Jason R. Thomas, Paula Bernasconi-Elias, Elizabeth George, Ning Guo, Guglielmo Roma, Alicia Lindeman, Amy E. Palmer, Yi Yang, Bushell Simon, Luis Llamas, Haibing Guo, Kevin Xie, Stephen M. Canham, Samuel B. Ho, Kyle P. Carter, Nicolette Guthrie, Somnath Bandyopadhyay, John S. Reece-Hoyes
Publikováno v:
Nat Chem Biol
The identification of activating mutations in NOTCH1 in 50% of T cell acute lymphoblastic leukemia has generated interest in elucidating how these mutations contribute to oncogenic transformation and in targeting the pathway. A phenotypic screen iden
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ddf3ead086ac61a242ea003075d48c87
https://pubmed.ncbi.nlm.nih.gov/30643281
https://pubmed.ncbi.nlm.nih.gov/30643281
Autor:
Zhao B. Kang, Ophelia Ardayfio, Thomas M. Smith, W. Adam Hill, Douglas S. Auld, Iain M. Wallace, Ji-Hu Zhang, Scott Bowes, Pei-i Ho
Publikováno v:
SLAS Discovery. 19:651-660
Pilot testing of an assay intended for high-throughput screening (HTS) with small compound sets is a necessary but often time-consuming step in the validation of an assay protocol. When the initial testing concentration is less than optimal, this can
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::815b80704faf450d770c374a114b7840
https://doi.org/10.1177/1087057113512151
https://doi.org/10.1177/1087057113512151
Autor:
Kavitha Venkatesan, Jaison Jacob, Shumei Liu, Fei Feng, Brandon Antonakos, Zhao B. Kang, Jonathan R. LaRochelle, Jason R. Dobson, Hui Gao, Laura R. La Bonte, Huaixiang Hao, Rajesh Karki, Samuel B. Ho, Guizhi Yang, Markus Warmuth, Ping Zhu, Matthew J. LaMarche, Brant Firestone, Matthew J. Meyer, Stephen C. Blacklow, Edmund Price, Kathy Hsiao, Jorge Garcia-Fortanet, Zhuoliang Chen, Chen Christine Hiu-Tung, Palermo Mark G, Vesselina G. Cooke, Cary Fridrich, Jay Larrow, Ping Wang, Sarah Williams, Ying-Nan P. Chen, Subarna Shakya, William R. Sellers, Nicholas Keen, Jing Yuan, Michael Shultz, Gang Liu, Michelle Fodor, Michael G. Acker, Pascal D. Fortin, Ho Man Chan, Timothy Michael Ramsey, Zhan Deng, Ji-Hu Zhang, Mitsunori Kato, Dyuti Majumdar, Peter Fekkes, Minying Pu, Travis Stams
Publikováno v:
Cancer Research. 77:2084-2084
The non-receptor protein tyrosine phosphatase (PTP) SHP2 is an important component of RTK signaling in response to growth factor stimulus and sits just upstream of the RAS-MAPK signaling cascade. The first oncogenic phosphatase to be identified, SHP2
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::80f0adb45534299e221531ab3cb2b319
https://doi.org/10.1158/1538-7445.am2017-2084
https://doi.org/10.1158/1538-7445.am2017-2084
Autor:
Joanne E. Cluette-Brown, Alexander Leaf, Michael Laposata, Zhao B. Kang, Yinlin Ge, Zhihong Chen, Jing X. Kang
Publikováno v:
Proceedings of the National Academy of Sciences. 98:4050-4054
Omega−3 polyunsaturated fatty acids (PUFAs) are essential components required for normal cellular function and have been shown to exert many preventive and therapeutic actions. The amount of n −3 PUFAs is insufficient in most Western people, wher
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e7fc0db81beb11c9fef7efd6d279ce22
https://doi.org/10.1073/pnas.061040198
https://doi.org/10.1073/pnas.061040198
Publikováno v:
Nature. 427(6974)
Mammals cannot naturally produce omega-3 (n-3) fatty acids--beneficial nutrients found mainly in fish oil--from the more abundant omega-6 (n-6) fatty acids and so they must rely on a dietary supply. Here we show that mice engineered to carry a fat-1
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::c8d9784270ca1e89811674782b6da0ba
https://pubmed.ncbi.nlm.nih.gov/14765186
https://pubmed.ncbi.nlm.nih.gov/14765186