Zobrazeno 1 - 10
of 38
pro vyhledávání: '"Zhanru Yu"'
Autor:
Andrea Stieger, Markus Huber, Zhanru Yu, Benedikt M. Kessler, Roman Fischer, Lukas Andereggen, Beatrice Kobel, Frank Stueber, Markus M. Luedi, Mark G. Filipovic
Publikováno v:
Metabolites, Vol 14, Iss 6, p 334 (2024)
Indoleamine 2,3-deoxygenase (IDO) plays an important role in the catabolism of the amino acid tryptophan. Tryptophan and its metabolites are key immune modulators. Increased IDO activity has been observed in various diseases and is associated with wo
Externí odkaz:
https://doaj.org/article/77b704bcadc54666b95bb6076a0c87f0
Autor:
Dedrick Kok Hong Chan, Amit Mandal, Svenja Hester, Zhanru Yu, Geoff Stuart Higgins, Benedikt Mathias Kessler, Roman Fischer, Simon James Alexander Buczacki
Publikováno v:
Cell Death Discovery, Vol 9, Iss 1, Pp 1-15 (2023)
Abstract Colorectal cancer possesses marked intratumoral heterogeneity. While subclonal interactions between Vogelstein driver mutations have been extensively studied, less is known about competitive or cooperative effects between subclonal populatio
Externí odkaz:
https://doaj.org/article/65b8402923f940d589405975c7c13b1c
Autor:
Dannielle Wellington, Zixi Yin, Zhanru Yu, Raphael Heilig, Simon Davis, Roman Fischer, Suet Ling Felce, Elie Antoun, Philip Hublitz, Ryan Beveridge, Danning Dong, Guihai Liu, Xuan Yao, Yanchun Peng, Benedikt M. Kessler, Tao Dong
Publikováno v:
Heliyon, Vol 9, Iss 10, Pp e20076- (2023)
Mutations within viral epitopes can result in escape from T cells, but the contribution of mutations in flanking regions of epitopes in SARS-CoV-2 has not been investigated. Focusing on two SARS-CoV-2 nucleoprotein CD8+ epitopes, we investigated the
Externí odkaz:
https://doaj.org/article/6ad5a37bf795450a95196caf30c2d01b
Publikováno v:
International Journal of Molecular Sciences, Vol 24, Iss 21, p 15513 (2023)
Bioactive lipids are involved in cellular signalling events with links to human disease. Many of these are involved in inflammation under normal and pathological conditions. Despite being attractive molecules from a pharmacological point of view, the
Externí odkaz:
https://doaj.org/article/74fd53cb8be740cbbd8b41c3fc497fea
Autor:
Duncan Howie, Annemieke Ten Bokum, Stephen Paul Cobbold, Zhanru Yu, Benedikt M. Kessler, Herman Waldmann
Publikováno v:
Frontiers in Immunology, Vol 10 (2019)
Lipid metabolism plays a key role in many cellular processes. We show here that regulatory T cells have enhanced lipid storage within subcellular lipid droplets (LD). They also express elevated amounts of both isoforms of diacylglycerol acyl transfer
Externí odkaz:
https://doaj.org/article/f1f9bc97d22942d6bcb3dcfc255163fd
Autor:
Dannielle Wellington, Zixi Yin, Zhanru Yu, Raphael Heilig, Simon Davis, Roman Fischer, Suet Ling Felce, Philip Hublitz, Ryan Beveridge, Danning Dong, Guihai Liu, Xuan Yao, Yanchun Peng, Benedikt M Kessler, Tao Dong
Viral CD8+ epitopes are generated by the cellular turnover of viral proteins, predominantly by the proteasome. Mutations located within viral epitopes can result in escape from memory T cells but the contribution of mutations in flanking regions of e
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b51917806e138b51603d153c93457115
https://doi.org/10.1101/2022.04.08.487623
https://doi.org/10.1101/2022.04.08.487623
Autor:
F. Manig, Michael Baumann, Oleg Chen, Oleh V. Stasyk, Zhanru Yu, Leoni A. Kunz-Schughart, Benedikt M. Kessler, Anna Dubrovska, Loreen Lehmann, Nagwa Sorour, Steffen Löck
Publikováno v:
Cellular and Molecular Life Sciences 78(2021), 3021-3044
Cellular and Molecular Life Sciences
Cellular and Molecular Life Sciences
Arginine deprivation therapy (ADT) is a new metabolic targeting approach with high therapeutic potential for various solid cancers. Combination of ADT with low doses of the natural arginine analog canavanine effectively sensitizes malignant cells to
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::df213edef1933636ae00b4bbabbdef14
https://www.hzdr.de/publications/Publ-33956-1
https://www.hzdr.de/publications/Publ-33956-1
Autor:
Paresh Vyas, Uzi Gileadi, Vincenzo Cerundolo, Giorgio Napolitani, Lars Rønn Olsen, I-Jun Lau, Thomas A. Milne, Nicholas T. Crump, Hashem Koohy, Zhanru Yu, Benedikt M. Kessler, Erica Ballabio, Ji-Li Chen, John Walsby-Tickle, Mariolina Salio, Andreas V. Hadjinicolaou, Lynn Quek, Mike Bogetofte Barnkob, James S. O. McCullagh, Meng Xia, Laura Godfrey, Mashiko Setshedi, Stephen Taylor
Publikováno v:
Cell Reports
Crump, N T, Hadjinicolaou, A V, Xia, M, Walsby-Tickle, J, Gileadi, U, Chen, J L, Setshedi, M, Olsen, L R, Lau, I J, Godfrey, L, Quek, L, Yu, Z, Ballabio, E, Barnkob, M B, Napolitani, G, Salio, M, Koohy, H, Kessler, B M, Taylor, S, Vyas, P, McCullagh, J S O, Milne, T A & Cerundolo, V 2021, ' Chromatin accessibility governs the differential response of cancer and T cells to arginine starvation ', Cell Reports, vol. 35, no. 6, 109101 . https://doi.org/10.1016/j.celrep.2021.109101
Crump, N T, Hadjinicolaou, A V, Xia, M, Walsby-Tickle, J, Gileadi, U, Chen, J L, Setshedi, M, Olsen, L R, Lau, I J, Godfrey, L, Quek, L, Yu, Z, Ballabio, E, Barnkob, M B, Napolitani, G, Salio, M, Koohy, H, Kessler, B M, Taylor, S, Vyas, P, McCullagh, J S O, Milne, T A & Cerundolo, V 2021, ' Chromatin accessibility governs the differential response of cancer and T cells to arginine starvation ', Cell Reports, vol. 35, no. 6, 109101 . https://doi.org/10.1016/j.celrep.2021.109101
Summary Depleting the microenvironment of important nutrients such as arginine is a key strategy for immune evasion by cancer cells. Many tumors overexpress arginase, but it is unclear how these cancers, but not T cells, tolerate arginine depletion.
Autor:
Zhanru Yu, Stephen P. Cobbold, Annemieke Ten Bokum, Benedikt M. Kessler, Herman Waldmann, Duncan Howie
Publikováno v:
Frontiers in Immunology, Vol 10 (2019)
Frontiers in Immunology
Frontiers in Immunology
Lipid metabolism plays a key role in many cellular processes. We show here that regulatory T cells have enhanced lipid storage within subcellular lipid droplets (LD). They also express elevated amounts of both isoforms of diacylglycerol acyl transfer
Autor:
Tommy Weiss-Sadan, Mohamed Mahameed, Gal Itzhak, Emmanuelle Merquiol, Zhanru Yu, Farnusch Kaschani, Boaz Tirosh, Benedikt M. Kessler, Markus Kaiser, Yael Ben-Nun, Galia Blum, Adi Anaki
Publikováno v:
Molecular & Cellular Proteomics : MCP
Remodeling of cellular metabolism is a genuine feature of rapidly growing cells. Herein we report that mouse embryonic fibroblasts, lacking the Cathepsin L (Cts L) gene, proliferate faster than wild-types and display a noticeable glycolytic shift to