Zobrazeno 1 - 9
of 9
pro vyhledávání: '"Zhannan Han"'
Autor:
Anna Bianchi-Smiraglia, David W. Wolff, Daniel J. Marston, Zhiyong Deng, Zhannan Han, Sudha Moparthy, Rebecca M. Wombacher, Ashley L. Mussell, Shichen Shen, Jialin Chen, Dong-Hyun Yun, Anderson O’Brien Cox, Cristina M. Furdui, Edward Hurley, Maria Laura Feltri, Jun Qu, Thomas Hollis, Jules Berlin Nde Kengne, Bernard Fongang, Rui J. Sousa, Mikhail E. Kandel, Eugene S. Kandel, Klaus M. Hahn, Mikhail A. Nikiforov
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-15 (2021)
Changes in intracellular GTP levels are not considered as a regulatory event in RAC1 activation in live cells since total GTP levels are substantially higher than the RAC1 GTP dissociation constant determined in vitro. Here, the authors demonstrate t
Externí odkaz:
https://doaj.org/article/8aee079d643942f4a47c971818bffc85
Autor:
Anna Bianchi-Smiraglia, David W. Wolff, Daniel J. Marston, Zhiyong Deng, Zhannan Han, Sudha Moparthy, Rebecca M. Wombacher, Ashley L. Mussell, Shichen Shen, Jialin Chen, Dong-Hyun Yun, Anderson O’Brien Cox, Cristina M. Furdui, Edward Hurley, Maria Laura Feltri, Jun Qu, Thomas Hollis, Jules Berlin Nde Kengne, Bernard Fongang, Rui J. Sousa, Mikhail E. Kandel, Eugene S. Kandel, Klaus M. Hahn, Mikhail A. Nikiforov
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-1 (2021)
Externí odkaz:
https://doaj.org/article/09f7fc50b96d4098b94d7fd143a62297
Autor:
Thomas Hollis, Maria Laura Feltri, Anderson O’Brien Cox, Jun Qu, Jules Berlin Nde Kengne, Zhiyong Deng, Jialin Chen, Rebecca M. Wombacher, Anna Bianchi-Smiraglia, Mikhail E. Kandel, Klaus M. Hahn, Shichen Shen, Sudha Moparthy, David W. Wolff, Bernard Fongang, Ashley L. Mussell, Eugene S. Kandel, Cristina M. Furdui, Rui J Sousa, Mikhail A. Nikiforov, Daniel J. Marston, Zhannan Han, Dong Hyun Yun, Edward Hurley
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-1 (2021)
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7862eeaa872e2f92eb1d2aa7eacb8a30
https://doi.org/10.1038/s41467-021-26665-2
https://doi.org/10.1038/s41467-021-26665-2
Autor:
Klaus M. Hahn, Shichen Shen, Jules Berlin Nde Kengne, Rebecca M. Wombacher, Anna Bianchi-Smiraglia, Mikhail A. Nikiforov, Jun Qu, Zhiyong Deng, Daniel J. Marston, Eugene S. Kandel, Zhannan Han, Cristina M. Furdui, Bernard Fongang, Dong Hyun Yun, Mikhail E. Kandel, Edward Hurley, Maria Laura Feltri, Anderson O’Brien Cox, Ashley L. Mussell, Jialin Chen, Thomas Hollis, Sudha Moparthy, David W. Wolff, Rui J Sousa
Publikováno v:
Nature Communications
Nature Communications, Vol 12, Iss 1, Pp 1-15 (2021)
Nature Communications, Vol 12, Iss 1, Pp 1-15 (2021)
Physiological changes in GTP levels in live cells have never been considered a regulatory step of RAC1 activation because intracellular GTP concentration (determined by chromatography or mass spectrometry) was shown to be substantially higher than th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1cbb06e57d207fc15afead7eab17e0a9
http://europepmc.org/articles/PMC8526568
http://europepmc.org/articles/PMC8526568
Autor:
David W. Wolff, Zhiyong Deng, Anna Bianchi-Smiraglia, Colleen E. Foley, Zhannan Han, Xingyou Wang, Shichen Shen, Masha M. Rosenberg, Sudha Moparthy, Dong Hyun Yun, Jialin Chen, Brian K. Baker, Matthew V. Roll, Andrew J. Magiera, Jun Li, Edward Hurley, Maria Laura Feltri, Anderson O. Cox, Jingyun Lee, Cristina M. Furdui, Liang Liu, Wiam Bshara, Leslie E.W. LaConte, Eugene S. Kandel, Elena B. Pasquale, Jun Qu, Lizbeth Hedstrom, Mikhail A. Nikiforov
Publikováno v:
Cell Chem Biol
Signal transduction pathways post-translationally regulating nucleotide metabolism remain largely unknown. Guanosine monophosphate reductase (GMPR) is a nucleotide metabolism enzyme that decreases GTP pools by converting GMP to IMP. We observed that
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::95cde5a0b391c456ceb2530059296c57
https://pubmed.ncbi.nlm.nih.gov/35148834
https://pubmed.ncbi.nlm.nih.gov/35148834
Autor:
Anna Bianchi-Smiraglia, Emily E. Fink, Zhannan Han, Sudha Moparthy, Jingyun Lee, Mikhail A. Nikiforov, Adam Utley, David W. Wolff, Cristina M. Furdui, Liang Liu, Brittany C. Lipchick, Kelvin P. Lee, Dong Hyun Yun
Publikováno v:
Blood Adv
Resistance to the proteasome inhibitor bortezomib (BTZ) represents a major obstacle in the treatment of multiple myeloma (MM). The contribution of lipid metabolism in the resistance of MM cells to BTZ is mostly unknown. Here we report that levels of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4f6519c26a49cbfd2bbc4c6c8f2edb86
https://europepmc.org/articles/PMC8045499/
https://europepmc.org/articles/PMC8045499/
Autor:
Cesar Rodriguez, David W. Wolff, Wiam Bshara, Eugene S. Kandel, A. E. Berman, Nadezhda I. Kozlova, Zhannan Han, Anna Bianchi-Smiraglia, Brittany C. Lipchick, Sudha Moparthy, Peter Jowdy, Emily E. Fink, Matthew V. Roll, Archis Bagati, Dong Hyun Yun, Maria S. Soengas, Mikhail A. Nikiforov, Olga Udartseva, György Paragh, Neil F. Box, Masha Kolesnikova
Although antioxidants promote melanoma metastasis, the role of reactive oxygen species (ROS) in other stages of melanoma progression is controversial. Moreover, genes regulating ROS have not been functionally characterized throughout the entire tumor
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c0786ca3d432b78462458d82736c4e12
https://europepmc.org/articles/PMC6939757/
https://europepmc.org/articles/PMC6939757/
Autor:
Spencer Rosario, Katerina I. Leonova, Kalyana Moparthy, Kelvin P. Lee, Andrei V. Gudkov, David W. Wolff, Aryn M. Rowsam, Anna Bianchi-Smiraglia, Mark D. Long, Eugene S. Kandel, P. Leif Bergsagel, Emily E. Fink, Hayley C. Affronti, Matthew V. Roll, Sudha Moparthy, Zhannan Han, Anthony Polechetti, Ilya Gitlin, Shivana M. Lightman, Dong Hyun Yun, Archis Bagati, Dominic J. Smiraglia, Brittany C. Lipchick, Mikhail A. Nikiforov
Publikováno v:
The Journal of clinical investigation. 128(10)
Polyamine inhibition for cancer therapy is, conceptually, an attractive approach but has yet to meet success in the clinical setting. The aryl hydrocarbon receptor (AHR) is the central transcriptional regulator of the xenobiotic response. Our study r
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2d990e088cba77cb1a625050ba8c4b11
https://pubmed.ncbi.nlm.nih.gov/30198903
https://pubmed.ncbi.nlm.nih.gov/30198903
Inhibition of the aryl hydrocarbon receptor/polyamine biosynthesis axis suppresses multiple myeloma.
Autor:
Bianchi-Smiraglia, Anna1, Bagati, Archis1, Fink, Emily E.1, Affronti, Hayley C.2, Lipchick, Brittany C.1,3, Moparthy, Sudha1,3, Long, Mark D.2, Rosario, Spencer R.2, Lightman, Shivana M.4, Moparthy, Kalyana1,3, Wolff, David W.1,3, Dong Hyun Yun1, Zhannan Han1,3, Polechetti, Anthony1, Roll, Matthew V.1,3, Gitlin, Ilya I.1, Leonova, Katerina I.1, Rowsam, Aryn M.2, Kandel, Eugene S.1, Gudkov, Andrei V.1
Publikováno v:
Journal of Clinical Investigation. Oct2018, Vol. 128 Issue 10, p4682-4696. 15p.