Zobrazeno 1 - 10
of 12
pro vyhledávání: '"Zhanna Yekhtin"'
Publikováno v:
Biomedicines, Vol 10, Iss 8, p 1793 (2022)
Phytocannabinoids possess a wide range of immune regulatory properties, mediated by the endocannabinoid system. Monocyte/macrophage innate immune cells express endocannabinoid receptors. Dysregulation of macrophage function is involved in the pathoge
Externí odkaz:
https://doaj.org/article/cc8a0f387bcb4aa19e5f64de70192e56
Autor:
Natalya M. Kogan, Yarden Lavi, Louise M. Topping, Richard. O. Williams, Fiona E. McCann, Zhanna Yekhtin, Marc Feldmann, Ruth Gallily, Raphael Mechoulam
Publikováno v:
Molecules, Vol 26, Iss 18, p 5601 (2021)
Interest in CBG (cannabigerol) has been growing in the past few years, due to its anti-inflammatory properties and other therapeutic benefits. Here we report the synthesis of three new CBG derivatives (HUM-223, HUM-233 and HUM-234) and show them to p
Externí odkaz:
https://doaj.org/article/a6ffb15a4ba14101a91c716db021ac58
Publikováno v:
International Journal of Molecular Sciences, Vol 20, Iss 3, p 668 (2019)
Cannabinoids, the biologically active constituents of Cannabis, have potent neuronal and immunological effects. However, the basic and medical research dedicated to medical cannabis and cannabinoids is limited. The influence of these treatments on he
Externí odkaz:
https://doaj.org/article/06073c6fb7ee4d0ab5eb374479eaa270
Publikováno v:
Drug delivery and translational research.
Methionine aminopeptidase 2 (MetAp2) inhibition has been recognized as a promising approach for suppressing angiogenesis and cancer progression. Small molecule fumagillol derivatives with adamantane side groups were synthesized and evaluated for MetA
Autor:
Louise M. Topping, Yarden Lavi, Zhanna Yekhtin, Marc Feldmann, Natalya M. Kogan, Fiona E. McCann, Raphael Mechoulam, Richard O. Williams, Ruth Gallily
Publikováno v:
Molecules
Volume 26
Issue 18
Molecules, Vol 26, Iss 5601, p 5601 (2021)
Volume 26
Issue 18
Molecules, Vol 26, Iss 5601, p 5601 (2021)
Interest in CBG (cannabigerol) has been growing in the past few years, due to its anti-inflammatory properties and other therapeutic benefits. Here we report the synthesis of three new CBG derivatives (HUM-223, HUM-233 and HUM-234) and show them to p
Autor:
Reut Shainer, Osnat Almogi-Hazan, Lola Weiss, Reuven Or, Eytan R. Barnea, Martin Mueller, Charles Farnsworth, Chaya Brodie, Soren Hayrabedyan, Michael J. Paidas, Zhanna Yekhtin, Krassimira Todorova, Scott D. Newsome
Publikováno v:
Scientific Reports, Vol 9, Iss 1, Pp 1-12 (2019)
Scientific Reports, 9:12876. Nature Publishing Group
Hayrabedyan, Soren; Shainer, Reut; Yekhtin, Zhanna; Weiss, Lola; Almogi-Hazan, Osnat; Or, Reuven; Farnsworth, Charles L; Newsome, Scott; Todorova, Krassimira; Paidas, Michael J; Brodie, Chaya; Barnea, Eytan R; Mueller, Martin (2019). Synthetic PreImplantation Factor (sPIF) induces posttranslational protein modification and reverses paralysis in EAE mice. Scientific reports, 9(1), p. 12876. Springer Nature 10.1038/s41598-019-48473-x
Scientific Reports
Scientific Reports, 9:12876. Nature Publishing Group
Hayrabedyan, Soren; Shainer, Reut; Yekhtin, Zhanna; Weiss, Lola; Almogi-Hazan, Osnat; Or, Reuven; Farnsworth, Charles L; Newsome, Scott; Todorova, Krassimira; Paidas, Michael J; Brodie, Chaya; Barnea, Eytan R; Mueller, Martin (2019). Synthetic PreImplantation Factor (sPIF) induces posttranslational protein modification and reverses paralysis in EAE mice. Scientific reports, 9(1), p. 12876. Springer Nature 10.1038/s41598-019-48473-x
Scientific Reports
An autoimmune response against myelin protein is considered one of the key pathogenic processes that initiates multiple sclerosis (MS). The currently available MS disease modifying therapies have demonstrated to reduce the frequency of inflammatory a
Publikováno v:
International Journal of Molecular Sciences
Volume 20
Issue 3
International Journal of Molecular Sciences, Vol 20, Iss 3, p 668 (2019)
Volume 20
Issue 3
International Journal of Molecular Sciences, Vol 20, Iss 3, p 668 (2019)
Cannabinoids, the biologically active constituents of Cannabis, have potent neuronal and immunological effects. However, the basic and medical research dedicated to medical cannabis and cannabinoids is limited. The influence of these treatments on he
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 23:507-512
A series of novel 3-hydroxy vinylboronates which share structural similarities with sphingolipids were synthesized and tested in vitro and in vivo as anticancer agents. The molecules reduced cancer cell survival in vitro by influencing their sphingol
Autor:
Lellean JeBailey, Sivakumar Ramu, Ravi Amunugama, Zhanna Yekhtin, Osnat Almogi-Hazan, Israel Reibstein, Lola Weiss, Reuven Or, Alexander O. Vortmeyer, Michael Zeira, Eytan R. Barnea, Richard C. Jones, Steven A. Bernstein, Reut Shainer, Shimon Slavin, Michael J. Paidas
Publikováno v:
Journal of the Neurological Sciences. 312:146-157
Introduction Embryo-derived PIF modulates systemic maternal immunity without suppression. Synthetic analog (sPIF) prevents juvenile diabetes, preserves islet function, reducing oxidative stress/protein misfolding. We investigate sPIF effectiveness in
Autor:
Lola, Weiss, Steve, Bernstein, Richard, Jones, Ravi, Amunugama, David, Krizman, Lellean, Jebailey, Osnat, Almogi-Hazan, Osnat, Hazan, Zhanna, Yekhtin, Janna, Yachtin, Reut, Shiner, Israel, Reibstein, Elizabeth, Triche, Shimon, Slavin, Reuven, Or, Eytan R, Barnea
Publikováno v:
Endocrine. 40:41-54
Preimplantation factor (PIF) is a novel embryo-secreted immunomodulatory peptide. Its synthetic analog (sPIF) modulates maternal immunity without suppression. There is an urgent need to develop agents that could prevent the development of type 1 diab