Zobrazeno 1 - 10
of 143
pro vyhledávání: '"Zhanjun Hou"'
Autor:
Adrianne Wallace-Povirk, Lisa Rubinsak, Agnes Malysa, Sijana H. Dzinic, Manasa Ravindra, Mathew Schneider, James Glassbrook, Carrie O’Connor, Zhanjun Hou, Seongho Kim, Jessica Back, Lisa Polin, Robert T. Morris, Aleem Gangjee, Heather Gibson, Larry H. Matherly
Publikováno v:
Scientific Reports, Vol 12, Iss 1, Pp 1-15 (2022)
Abstract Novel therapies are urgently needed for epithelial ovarian cancer (EOC), the most lethal gynecologic malignancy. In addition, therapies that target unique vulnerabilities in the tumor microenvironment (TME) of EOC have largely been unrealize
Externí odkaz:
https://doaj.org/article/02853bc9f796452ca78238c2e5dbf371
Autor:
Carrie O’Connor, Adrianne Wallace-Povirk, Changwen Ning, Josephine Frühauf, Nian Tong, Aleem Gangjee, Larry H. Matherly, Zhanjun Hou
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-14 (2021)
Abstract There are three major folate uptake systems in human tissues and tumors, including the reduced folate carrier (RFC), folate receptors (FRs) and proton-coupled folate transporter (PCFT). We studied the functional interrelationships among thes
Externí odkaz:
https://doaj.org/article/dd3e87cff5634115a13acaae3166b8b6
Publikováno v:
Proteomes, Vol 10, Iss 2, p 18 (2022)
Localization of organelle proteins by isotope tagging (LOPIT) maps are a coordinate-directed representation of proteome data that can aid in biological interpretation. Analysis of organellar association for proteins as displayed using LOPIT is evalua
Externí odkaz:
https://doaj.org/article/87856088942044ba87ef78688adf2443
Autor:
Nian Tong, Jennifer Wong-Roushar, Adrianne Wallace-Povirk, Yesha Shah, Morgan C. Nyman, Jade M. Katinas, Mathew Schneider, Carrie O’Connor, Xun Bao, Seongho Kim, Jing Li, Zhanjun Hou, Larry H. Matherly, Charles E. Dann, Aleem Gangjee
Publikováno v:
ACS Pharmacology & Translational Science. 6:748-770
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::7c2d99f0e56cb14cc8298ab6d6766d24
https://doi.org/10.1021/acsptsci.3c00020
https://doi.org/10.1021/acsptsci.3c00020
Publikováno v:
Expert opinion on drug metabolismtoxicology. 18(10)
The proton-coupled folate transporter (PCFT; SLC46A1) was discovered in 2006 as the principal mechanism by which folates are absorbed in the intestine and the causal basis for hereditary folate malabsorption (HFM). In 2011, it was found that PCFT is
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::349e7cd47738e59d33f6c5663247548b
https://pubmed.ncbi.nlm.nih.gov/36239195
https://pubmed.ncbi.nlm.nih.gov/36239195
Autor:
Natalia Baran, Katie Hurrish, Yongwei Su, Shraddha Patel, Cassandra Ramage, Jenna Carter, Holly Edwards, Steven Buck, Sandra Wiley, Maik Hüttemann, Lisa Polin, Juiwanna Kushner, Sijana Dzinic, Kathryn White, Xun Bao, Jing Li, Jay Yang, Julie Boerner, Zhanjun Hou, Gheath Al-Atrash, Sergej Konoplev, Jonathan Busquets, Stefano Tiziani, Larry Matherly, Jeffrey Taub, Marina Konopleva, Yubin Ge
Venetoclax (VEN), in combination with low dose cytarabine (AraC) or a hypomethylating agent, is FDA approved to treat acute myeloid leukemia (AML) in patients who are over the age of 75 or cannot tolerate standard chemotherapy. Despite high response
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a03d99a8c2a425123fb511654ec9d36e
https://doi.org/10.21203/rs.3.rs-2843025/v1
https://doi.org/10.21203/rs.3.rs-2843025/v1
Autor:
Lei Cao, Jinyuan Guo, Hai Li, Hu Ren, Kang Xiao, Yan Zhang, Shuangli Zhu, Yang Song, Weijia Zhao, Dan Wu, Zhihui Chen, Yanan Zhang, Baicheng Xia, Tianjiao Ji, Dongmei Yan, Dongyan Wang, Qian Yang, Yangzi Zhou, Xiaolei Li, Zhanjun Hou, Wenbo Xu
Publikováno v:
Microbiology Spectrum. 11
Continuous emergence of adaptive mutations of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) continues to challenge the use and development of existing vaccines and drugs. The value of variant-based vaccines that are capable of inducing
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::8d479a997c1d862668f43f5dc370cfd7
https://doi.org/10.1128/spectrum.02687-22
https://doi.org/10.1128/spectrum.02687-22
Autor:
Larry H. Matherly, Aleem Gangjee, Robert T. Morris, Juiwanna Kushner, Kathryn White, Lisa Polin, Steve Orr, Christina George, Adrianne Wallace-Povirk, Si Yang, Carrie O'Connor, Leda Gattoc, Zhanjun Hou
Table S1: Epithelial ovarian cancer (EOC) tissue cDNA array for real-time RT-PCR (Figures 2A and 2B). Table S2. Epithelial ovarian cancer (EOC) tissue microarray (TMA) for immunohistochemistry (IHC; Figures 2C and 2D).
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::17f1ed0a289afe9ae49b45238fff404d
https://doi.org/10.1158/1535-7163.22504539.v1
https://doi.org/10.1158/1535-7163.22504539.v1
Autor:
Larry H. Matherly, Aleem Gangjee, Charles E. Dann, Zhanjun Hou, Jing Li, Joshua D. Rabinowitz, Lisa Polin, Maik Hüttemann, Seongho Kim, Juiwanna Kushner, Kathryn White, Sijana H. Dzinic, Carrie O'Connor, Adrianne Wallace-Povirk, Jenney Liu, Josephine Frühauf, Xun Bao, Changwen Ning, Arpit Doshi, Md. Junayed Nayeen, Jennifer Wong-Roushar, Jade M. Katinas, Gregory S. Ducker, Khushbu Shah, Aamod S. Dekhne
Supplementary Figure S1 shows in vitro antiproliferative activity and targeted pathways of previously reported AICARFTase and GARFTase inhibitors. Supplementary Figure S2 shows docking of AGF291, AGF320, and AGF347 (along with 5-formyl-THF) in human
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2f58160726ffe67fe411c78ec2698b22
https://doi.org/10.1158/1535-7163.22505523.v1
https://doi.org/10.1158/1535-7163.22505523.v1
Autor:
Ayesha Alvero, Ramandeep Rattan, Zhanjun Hou, Sandra Galoforo, Alexandra Fox, Seongo Kim, Rouba Ali-Fehmi, Mira Kheil, Robert Morris, Larry Matherly, Gil Mor, Radhika Gogoi
Publikováno v:
E-Posters.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::da85c26c0fb7765c1f6c798462e141be
https://doi.org/10.1136/ijgc-2022-igcs.308
https://doi.org/10.1136/ijgc-2022-igcs.308