Discovery of novel multidrug resistance protein 4 (MRP4) inhibitors as active agents reducing resistance to anticancer drug 6-Mercaptopurine (6-MP) by structure and ligand-based virtual screening.

Autor: Ya Chen, Xia Yuan, Zhangping Xiao, Hongwei Jin, Liangren Zhang, Zhenming Liu

Publikováno v: PLoS ONE, Vol 13, Iss 10, p e0205175 (2018)

Multidrug resistance protein 4 (MRP4/ABCC4) is an ATP-binding cassette (ABC) transporter. It is associated with multidrug resistance (MDR), which is becoming a growing challenge to the treatment of cancer and infections. In the context of several typ

Externí odkaz: https://doaj.org/article/8ef2796ea61e4c8485c0b5e53815d5d0

Identification of a Bromodomain-like region in 15-Lipoxygenase-1 explains its Nuclear Localization

Autor: Petra E van der Wouden, Zhangping Xiao, Frank J. Dekker, Deng Chen, Dea Gogishvili, Rita Setroikromo, Hao Guo

Publikováno v: Angewandte Chemie (International Ed. in English)
Angewandte Chemie (International ed. in English), 60(40), 21875-21883. WILEY-V C H VERLAG GMBH

Lipoxygenase (LOX) activity provides oxidative lipid metabolites, which are involved in inflammatory disorders and tumorigenesis. Activity‐based probes to detect the activity of LOX enzymes in their cellular context provide opportunities to explore

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1fcaf1ff2001ab82da878efb2ea45452
https://doi.org/10.1002/anie.202106968

ElectrochemicalN-demethylation of tropane alkaloids

Autor: Zhangping Xiao, Frank J. Dekker, Ali Alipour Najmi, Rainer Bischoff, Hjalmar P. Permentier

Publikováno v: Green Chemistry, 22(19), 6455-6463. ROYAL SOC CHEMISTRY

A practical, efficient, and selective electrochemicalN-demethylation method of tropane alkaloids to their nortropane derivatives is described. Nortropanes, such as noratropine and norscopolamine, are important intermediates for the semi-synthesis of

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3b19b83f3ad57eb2311181268e002a55
https://hdl.handle.net/11370/7ab92aac-15b5-4084-a8ac-fe9a29c06a70

4-Iodopyrimidine labeling reveals nuclear translocation and nuclease activity for both MIF and MIF2

Autor: Zhangping Xiao, Frank J. Dekker, Shanshan Song, Robbert H. Cool, Fabian Mulder, Deng Chen, Barbro N. Melgert, Petra E van der Wouden, Gerrit J. Poelarends

Publikováno v: Chemistry, 28(1):e202103030. Wiley-VCH Verlag GmbH & Co. KGaA

Macrophage migration inhibitory factor (MIF) and its homolog MIF2 (also known as D-dopachrome tautomerase or DDT) play key roles in cell growth and immune responses. MIF and MIF2 expression is dysregulated in cancers and neurodegenerative diseases. A

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e5c23129d373dc0f1773f9f19268eb5a
https://research.rug.nl/en/publications/4380903a-9d91-4662-8ef1-9828d3a7c6bd

Cyclic diguanylate analogues: Facile synthesis, STING binding mode and anti-tumor immunity delivered by cytidinyl/cationic lipid

Autor: Xudong, Sun, Xiaotong, Yu, Yaqi, Zhao, Lei, Xing, Luxin, Na, Zhuo, Chen, Zhangping, Xiao, Hong, Dai, Jing, Yu, Sijie, Long, Quanxin, Wang, Xiaofan, Shi, Zhu, Guan, Ming, Lei, Zhenjun, Yang

Publikováno v: European Journal of Medicinal Chemistry. 247:115053

Herein 2-cyanoethoxy-N,N,N',N'-tetraisopropyl-phosphorodiamidite(10, P

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ba08288d5d5128d6f472529b86453116
https://doi.org/10.1016/j.ejmech.2022.115053