Zobrazeno 1 - 10
of 301
pro vyhledávání: '"Zhanglin Lin"'
Publikováno v:
Microbial Cell Factories, Vol 23, Iss 1, Pp 1-11 (2024)
Abstract Background Microbial organisms hold significant potential for converting renewable substrates into valuable chemicals. Low pH fermentation in industrial settings offers key advantages, including reduced neutralizer usage and decreased wastew
Externí odkaz:
https://doaj.org/article/1245f48efa6549faaf7f670d8586ef2c
Publikováno v:
Synthetic and Systems Biotechnology, Vol 9, Iss 3, Pp 462-469 (2024)
In industrial fermentation processes, microorganisms often encounter acid stress, which significantly impact their productivity. This study focused on the acid-resistant module composed of small RNA (sRNA) DsrA and the sRNA chaperone Hfq. Our previou
Externí odkaz:
https://doaj.org/article/c8c16c7244dc4c46985fb06346665c48
Publikováno v:
Catalysts, Vol 14, Iss 9, p 651 (2024)
Protein purification is essential in life sciences and biomanufacturing. Tag-mediated protein affinity chromatography (AC) enables the preparation of recombinant proteins with medium to high purity. However, traditional AC methods often require expen
Externí odkaz:
https://doaj.org/article/ebbccd0865c34d1dbc160499ab67b845
Publikováno v:
Microbial Cell Factories, Vol 22, Iss 1, Pp 1-11 (2023)
Abstract Background Protein purification remains a critical need for biosciences and biotechnology. It frequently requires multiple rounds of chromatographic steps that are expensive and time-consuming. Our lab previously reported a cleavable self-ag
Externí odkaz:
https://doaj.org/article/452c8320b7cc4dd7a2e99ad1ff2257bc
Autor:
Alistair Ring, Meghan Karuturi, Emily Nash Smyth, Tasneem Lokhandwala, Kristin M. Sheffield, Joanne Willey, Orsolya Lunacsek, Francisco Sapunar, Zhanglin Lin Cui, Anna D. Coutinho, Sarah Rybowski
Publikováno v:
Drugs - Real World Outcomes, Vol 10, Iss 4, Pp 589-603 (2023)
Abstract Introduction Hormone receptor-positive (HR+)/human epidermal growth factor receptor 2-negative (HER2−) is the most frequently diagnosed metastatic breast cancer (mBC) subtype. Combinations of endocrine therapy (ET) with cyclin-dependent ki
Externí odkaz:
https://doaj.org/article/aa1788c9bb694e03a3c95d560933648e
Publikováno v:
Viruses, Vol 16, Iss 3, p 422 (2024)
Phages provide a potential therapy for multi-drug-resistant (MDR) bacteria. However, a significant portion of viral genes often remains unknown, posing potential dangers. The identification of non-essential genes helps dissect and simplify phage geno
Externí odkaz:
https://doaj.org/article/01714a187f054434968ee6468a75e776
Publikováno v:
BMC Bioinformatics, Vol 23, Iss 1, Pp 1-12 (2022)
Abstract Background Compound–protein interaction site and binding affinity predictions are crucial for drug discovery and drug design. In recent years, many deep learning-based methods have been proposed for predications related to compound–prote
Externí odkaz:
https://doaj.org/article/dc75f63efeef4c97aed711213f30196c
Publikováno v:
Catalysts, Vol 13, Iss 12, p 1457 (2023)
Fructose-1,6-bisphosphate aldolase (FBA) is an important enzyme involved in central carbon metabolism (CCM) with promising industrial applications. Artificial intelligence models like generative adversarial networks (GANs) can design novel sequences
Externí odkaz:
https://doaj.org/article/820fe4596c854be1a289b720321a3e77
Publikováno v:
Microbial Cell Factories, Vol 21, Iss 1, Pp 1-14 (2022)
Abstract Background During fermentation, industrial microorganisms encounter multiple stresses that inhibit cell growth and decrease fermentation yields, in particular acid stress, which is due to the accumulation of acidic metabolites in the ferment
Externí odkaz:
https://doaj.org/article/2d73493b8a904d738cfc6f1533a33e32
Publikováno v:
Journal of Comparative Effectiveness Research, Vol 12, Iss 2 (2023)
Aim: This real-world study aims to compare overall survival (OS) associated with biweekly (Q2W) versus weekly (Q1W) cetuximab dosing regimens for metastatic colorectal cancer (mCRC) treatment in the US. Methods: Adult patients with KRAS wild-type m
Externí odkaz:
https://doaj.org/article/3d3a14ada5a24baf94879848d762bf5d