Zobrazeno 1 - 4
of 4
pro vyhledávání: '"Zhangdan Xie"'
Autor:
Xinyu Mei, Yuan Guo, Zhangdan Xie, Yedan Zhong, Xiaofen Wu, Daichao Xu, Ying Li, Nan Liu, Zheng-Jiang Zhu
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-16 (2021)
RIPK1 is critical for normal development and cell death. Here, the authors identify a metabolic role for RIPK1 in aspartate homeostasis, as increased aspartate levels in RIPK1-deficient cells inhibits starvation-induced autophagy by ULK1.
Externí odkaz:
https://doaj.org/article/616955a444454b12b563bea2f8d81e5e
Autor:
Huibing Wang, Weiwei Qi, Chengyu Zou, Zhangdan Xie, Mengmeng Zhang, Masanori Gomi Naito, Lauren Mifflin, Zhen Liu, Ayaz Najafov, Heling Pan, Bing Shan, Ying Li, Zheng-Jiang Zhu, Junying Yuan
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-19 (2021)
NEK1 mutations promote lethality early in life and ALS late in life via unknown mechanisms. Here, the authors show that NEK1 mutation disrupts retromer-mediated trafficking and promotes RIPK1 activation, connecting retromer trafficking and metabolism
Externí odkaz:
https://doaj.org/article/4294aac17a8b4f399739cdbf82ea2a17
Autor:
Yedan Zhong, Xiaofen Wu, Xinyu Mei, Ying Li, Daichao Xu, Zhangdan Xie, Yuan Guo, Nan Liu, Zheng-Jiang Zhu
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-16 (2021)
Nature Communications
Nature Communications
RIPK1 is a crucial regulator of cell death and survival. Ripk1 deficiency promotes mouse survival in the prenatal period while inhibits survival in the early postnatal period without a clear mechanism. Metabolism regulation and autophagy are critical
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c0054cbe3d6778d306a299c769a146c5
https://doaj.org/article/616955a444454b12b563bea2f8d81e5e
https://doaj.org/article/616955a444454b12b563bea2f8d81e5e
Autor:
Heling Pan, Ying Li, Zhangdan Xie, Lauren Mifflin, Zheng-Jiang Zhu, Chengyu Zou, H. Wang, Junying Yuan, Mengmeng Zhang, Weiwei Qi, Zhen Liu, Bing Shan, Masanori Gomi Naito, Ayaz Najafov
Publikováno v:
Nature Communications
Nature Communications, Vol 12, Iss 1, Pp 1-19 (2021)
Nature Communications, Vol 12, Iss 1, Pp 1-19 (2021)
Loss-of-function mutations in NEK1 gene, which encodes a serine/threonine kinase, are involved in human developmental disorders and ALS. Here we show that NEK1 regulates retromer-mediated endosomal trafficking by phosphorylating VPS26B. NEK1 deficien
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7bd6dd563e34b8e44136b534464d83da
http://europepmc.org/articles/PMC8355301
http://europepmc.org/articles/PMC8355301