Phenotypic screening identifies a trisubstituted imidazo[1,2-a]pyridine series that induces differentiation in multiple AML cell lines

Autor: Josa-Culleré, Laia, Galan, Sébastien R.G., Cogswell, Thomas J., Jackson, Thomas R., Jay-Smith, Morgan, Mola, Laura, Greaves, Christopher R., Carter, Tom S., Madden, Katrina S., Trott, Sophie, Zhang, Douzi, Bataille, Carole J.R., Davies, Stephen G., Vyas, Paresh, Milne, Thomas A., Naylor, Alan, Wynne, Graham M., Russell, Angela J.

Publikováno v: In European Journal of Medicinal Chemistry 5 October 2023 258

A tubulin binding molecule drives differentiation of acute myeloid leukemia cells

Autor: Jackson, Thomas R., Vuorinen, Aini, Josa-Culleré, Laia, Madden, Katrina S., Conole, Daniel, Cogswell, Thomas J., Wilkinson, Isabel V.L., Kettyle, Laura M., Zhang, Douzi, O’Mahony, Alison, Gracias, Deanne, McCall, Lorna, Westwood, Robert, Terstappen, Georg C., Davies, Stephen G., Tate, Edward W., Wynne, Graham M., Vyas, Paresh, Russell, Angela J., Milne, Thomas A.

Publikováno v: In iScience 19 August 2022 25(8)

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Lead optimisation of OXS007417: in vivo PK profile and hERG liability modulation to optimise a small molecule differentiation agent for the potential treatment of acute myeloid leukaemia.

Autor: Cogswell TJ; Department of Chemistry, Chemistry Research Laboratory, University of Oxford Mansfield Road Oxford OX1 3TA UK angela.russell@chem.ox.ac.uk., Josa-Culleré L; Department of Chemistry, Chemistry Research Laboratory, University of Oxford Mansfield Road Oxford OX1 3TA UK angela.russell@chem.ox.ac.uk., Zimmer D; Department of Chemistry, Chemistry Research Laboratory, University of Oxford Mansfield Road Oxford OX1 3TA UK angela.russell@chem.ox.ac.uk., Galan SRG; Department of Chemistry, Chemistry Research Laboratory, University of Oxford Mansfield Road Oxford OX1 3TA UK angela.russell@chem.ox.ac.uk., Jay-Smith M; Department of Chemistry, Chemistry Research Laboratory, University of Oxford Mansfield Road Oxford OX1 3TA UK angela.russell@chem.ox.ac.uk., Harris KS; Department of Chemistry, Chemistry Research Laboratory, University of Oxford Mansfield Road Oxford OX1 3TA UK angela.russell@chem.ox.ac.uk., Bataille CJR; Department of Chemistry, Chemistry Research Laboratory, University of Oxford Mansfield Road Oxford OX1 3TA UK angela.russell@chem.ox.ac.uk.; Department of Pharmacology, University of Oxford Mansfield Road Oxford OX1 3QT UK., Jackson TR; MRC Molecular Haematology Unit, MRC Weatherall Institute of Molecular Medicine, Radcliffe Department of Medicine, University of Oxford Oxford OX3 9DS UK., Zhang D; MRC Molecular Haematology Unit, MRC Weatherall Institute of Molecular Medicine, Radcliffe Department of Medicine, University of Oxford Oxford OX3 9DS UK., Davies SG; Department of Chemistry, Chemistry Research Laboratory, University of Oxford Mansfield Road Oxford OX1 3TA UK angela.russell@chem.ox.ac.uk., Vyas P; MRC Molecular Haematology Unit, MRC Weatherall Institute of Molecular Medicine, Radcliffe Department of Medicine, University of Oxford Oxford OX3 9DS UK., Milne TA; MRC Molecular Haematology Unit, MRC Weatherall Institute of Molecular Medicine, Radcliffe Department of Medicine, University of Oxford Oxford OX3 9DS UK., Wynne GM; Department of Chemistry, Chemistry Research Laboratory, University of Oxford Mansfield Road Oxford OX1 3TA UK angela.russell@chem.ox.ac.uk., Russell AJ; Department of Chemistry, Chemistry Research Laboratory, University of Oxford Mansfield Road Oxford OX1 3TA UK angela.russell@chem.ox.ac.uk.; Department of Pharmacology, University of Oxford Mansfield Road Oxford OX1 3QT UK.

Publikováno v: RSC medicinal chemistry [RSC Med Chem] 2024 Jul 22. Date of Electronic Publication: 2024 Jul 22.