Zobrazeno 1 - 10
of 27
pro vyhledávání: '"Zhanfeng Liang"'
Publikováno v:
Communications Biology, Vol 5, Iss 1, Pp 1-14 (2022)
Thymic epithelial cells (TECs) are essential for the production of self-tolerant T cells. Single-cell ATAC-seq of medullary TECs suggests that Sirt6-mediated epigenetic regulation may regulate the development of thymic tuft cells from these TECs.
Externí odkaz:
https://doaj.org/article/e83b2d84e9774c47994e9c4a03ae4c11
Autor:
Zhanfeng Liang, Zhaoqi Zhang, Qian Zhang, Xue Dong, Xiaofeng Yang, Jiayu Zhang, Tong Lei, John W.M. Creemers, Baojun Zhang, Yong Zhao
Publikováno v:
iScience, Vol 25, Iss 10, Pp 105233- (2022)
Summary: The generation of mature T cells and establishment of central tolerance is predominantly orchestrated by thymic epithelial cells (TECs). Proprotein convertases are responsible for the proteolysis of proproteins into their mature bioactive co
Externí odkaz:
https://doaj.org/article/bb6484086ae54c819f4a27879b0ccd2a
Publikováno v:
Frontiers in Immunology, Vol 13 (2022)
Thymic epithelial cells (TECs) critically participate in T cell maturation and selection for the establishment of immunity to foreign antigens and immune tolerance to self-antigens of T cells. It is well known that many intracellular and extracellula
Externí odkaz:
https://doaj.org/article/67ab092fd07341e0a5bea9aee607f935
Autor:
Qian Zhang, Zhanfeng Liang, Jiayu Zhang, Tong Lei, Xue Dong, Huiting Su, Yifang Chen, Zhaoqi Zhang, Liang Tan, Yong Zhao
Publikováno v:
Frontiers in Cell and Developmental Biology, Vol 9 (2021)
Although some advances have been made in understanding the molecular regulation of mTEC development, the role of epigenetic regulators in the development and maturation of mTEC is poorly understood. Here, using the TEC-specific Sirt6 knockout mice, w
Externí odkaz:
https://doaj.org/article/5b03556658564b3497814b4c6d86e24e
Autor:
Hong-Xia Wang, Wenrong Pan, Lei Zheng, Xiao-Ping Zhong, Liang Tan, Zhanfeng Liang, Jing He, Pingfeng Feng, Yong Zhao, Yu-Rong Qiu
Publikováno v:
Frontiers in Immunology, Vol 11 (2020)
Externí odkaz:
https://doaj.org/article/a7bb0878e49d4af49351899da8559c1e
Autor:
Hong-Xia Wang, Wenrong Pan, Lei Zheng, Xiao-Ping Zhong, Liang Tan, Zhanfeng Liang, Jing He, Pingfeng Feng, Yong Zhao, Yu-Rong Qiu
Publikováno v:
Frontiers in Immunology, Vol 10 (2020)
The thymus is the primary lymphoid organ responsible for the generation and maturation of T cells. Thymic epithelial cells (TECs) account for the majority of thymic stromal components. They are further divided into cortical and medullary TECs based o
Externí odkaz:
https://doaj.org/article/b514590a16594de7b0cc6b6cabd50755
Autor:
Xue, Dong, Zhanfeng, Liang, Jiayu, Zhang, Qian, Zhang, Yanan, Xu, Zhaoqi, Zhang, Lianfeng, Zhang, Baojun, Zhang, Yong, Zhao
Publikováno v:
European Journal of Immunology. 52:1789-1804
Thymic epithelial cells (TECs) are important for T cell development and immune tolerance establishment. Although comprehensive molecular regulation of TEC development has been studied, the role of transport protein particle complexes (Trappcs) in TEC
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::07105037e0ce597a70b96dbb6a6fefff
https://doi.org/10.1002/eji.202249915
https://doi.org/10.1002/eji.202249915
Autor:
Xubiao Xie, Zhaoqi Zhang, Xue Dong, Liguang Sun, Lina Sun, Tianxiu Li, Zhanfeng Liang, Liang Tan, Qian Zhang, Yong Zhao
Publikováno v:
The Journal of Immunology. 207:2039-2050
Thymic epithelial cells (TECs) are critical for the development and generation of functionally competent T cells. Until now, the mechanism that regulates the survival of TECs is poorly understood. In the current study, we found that Tsc1 controls the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cd7f4f20d53cb2997cd92f27e67fe603
https://doi.org/10.4049/jimmunol.2100463
https://doi.org/10.4049/jimmunol.2100463
Autor:
null Xue Dong, null Zhanfeng Liang, null Jiayu Zhang, null Qian Zhang, null Yanan Xu, null Zhaoqi Zhang, null Lianfeng Zhang, null Baojun Zhang, null Yong Zhao
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a7b06766335fc5f8844c5bcd30832c4f
https://doi.org/10.1002/eji.202249915/v3/response1
https://doi.org/10.1002/eji.202249915/v3/response1
Publikováno v:
Aging cell. 21(8)
The thymus is the primary immune organ responsible for generating self-tolerant and immunocompetent T cells. However, the thymus gradually involutes during early life resulting in declined naïve T-cell production, a process known as age-related thym
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::315439d5e9294bee4adb50d89bc9b3d9
https://pubmed.ncbi.nlm.nih.gov/35822239
https://pubmed.ncbi.nlm.nih.gov/35822239