Zobrazeno 1 - 10
of 478
pro vyhledávání: '"Zhan Guo Gao"'
Autor:
Naveen Thakur, Arka P. Ray, Liam Sharp, Beining Jin, Alexander Duong, Niloofar Gopal Pour, Samuel Obeng, Anuradha V. Wijesekara, Zhan-Guo Gao, Christopher R. McCurdy, Kenneth A. Jacobson, Edward Lyman, Matthew T. Eddy
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-13 (2023)
In cell membranes, lipids are ubiquitous regulators of protein function. Here, Thakur et al. observe anionic phospholipids impact the conformational dynamics of a class A human GPCR.
Externí odkaz:
https://doaj.org/article/c97c975e0e3f4ff491e2f710139cacce
Autor:
Ane Larrañaga-Vera, Kiran S. Toti, James S. Flatow, Alexandra J. Haraczy, Eugene Warnick, Harsha Rao, Zhan-Guo Gao, Sarah M. Sussman, Aranzazu Mediero, Philipp Leucht, Kenneth A. Jacobson, Bruce N. Cronstein
Publikováno v:
Arthritis Research & Therapy, Vol 24, Iss 1, Pp 1-13 (2022)
Abstract Loss of bone is a common medical problem and, while it can be treated with available therapies, some of these therapies have critical side effects. We have previously demonstrated that CGS21680, a selective A2A adenosine receptor agonist, pr
Externí odkaz:
https://doaj.org/article/a956a4a46ddb42f7bca1255f74162a82
Publikováno v:
iScience, Vol 26, Iss 7, Pp 107178- (2023)
Summary: Protein kinase C (PKC) isoforms regulate many important signaling pathways. Here, we report that PKC activation by phorbol 12-myristate 13-acetate (PMA) enhanced A2B adenosine receptor (AR)-mediated, but not β2-adrenergic receptor-mediated,
Externí odkaz:
https://doaj.org/article/126eeafbe008438ba5fb2a678efb27ec
Publikováno v:
Frontiers in Pharmacology, Vol 13 (2022)
Adenosine (ADO) is an extracellular signaling molecule generated locally under conditions that produce ischemia, hypoxia, or inflammation. It is involved in modulating a range of physiological functions throughout the brain and periphery through the
Externí odkaz:
https://doaj.org/article/2ef52e64f0274162a77eb5e38d30693e
Repurposing of a Nucleoside Scaffold from Adenosine Receptor Agonists to Opioid Receptor Antagonists
Autor:
Dilip K. Tosh, Antonella Ciancetta, Philip Mannes, Eugene Warnick, Aaron Janowsky, Amy J. Eshleman, Elizabeth Gizewski, Tarsis F. Brust, Laura M. Bohn, John A. Auchampach, Zhan-Guo Gao, Kenneth A. Jacobson
Publikováno v:
ACS Omega, Vol 3, Iss 10, Pp 12658-12678 (2018)
Externí odkaz:
https://doaj.org/article/1e1f1e1e4506436da0e5c5de6c1ad211
Autor:
Pierre Matricon, Anirudh Ranganathan, Eugene Warnick, Zhan-Guo Gao, Axel Rudling, Catia Lambertucci, Gabriella Marucci, Aitakin Ezzati, Mariama Jaiteh, Diego Dal Ben, Kenneth A. Jacobson, Jens Carlsson
Publikováno v:
Scientific Reports, Vol 7, Iss 1, Pp 1-12 (2017)
Abstract Fragment-based lead discovery is becoming an increasingly popular strategy for drug discovery. Fragment screening identifies weakly binding compounds that require optimization to become high-affinity leads. As design of leads from fragments
Externí odkaz:
https://doaj.org/article/24c1cb3e575e44c6b3e9de6c28191221
Autor:
Anna Shiriaeva, Daejin Park, Gyudong Kim, Yoonji Lee, Xiyan Hou, Dnyandev B. Jarhad, Gibae Kim, Jinha Yu, Young Eum Hyun, Woomi Kim, Zhan-Guo Gao, Kenneth A. Jacobson, Gye Won Han, Raymond C. Stevens, Lak Shin Jeong, Sun Choi, Vadim Cherezov
Publikováno v:
Journal of Medicinal Chemistry. 65:11648-11657
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::8b6f79bf66b85c0a0487a8a2f2f7e352
https://doi.org/10.1021/acs.jmedchem.2c00462
https://doi.org/10.1021/acs.jmedchem.2c00462
Autor:
Courtney L. Fisher, Lucas B. Fallot, Tina C. Wan, Robert F. Keyes, R. Rama Suresh, Amy C. Rothwell, Zhan-Guo Gao, John D. McCorvy, Brian C. Smith, Kenneth A. Jacobson, John A. Auchampach
Publikováno v:
ACS Pharmacology & Translational Science. 5:625-641
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::9a18e1bae71fc0155f4622d56a4848e1
https://doi.org/10.1021/acsptsci.2c00076
https://doi.org/10.1021/acsptsci.2c00076
Publikováno v:
Frontiers in Cellular Neuroscience, Vol 13 (2019)
Adenosine receptors (ARs) function in the body’s response to conditions of pathology and stress associated with a functional imbalance, such as in the supply and demand of energy/oxygen/nutrients. Extracellular adenosine concentrations vary widely
Externí odkaz:
https://doaj.org/article/ca6d33ed383a4da5aa674b2afa5d6228
Autor:
Kenneth Jacobson, Courtney Fisher, Veronica Salmaso, Tina C. Wan, Ryan G. Campbell, Eric Chen, Zhan-Guo Gao, John A. Auchampach, Dilip K. Tosh
Publikováno v:
ASPET 2023 Annual Meeting Abstract - Drug Discovery and Development.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c4e8963763bdd0f153db28975fe1126e
https://doi.org/10.1124/jpet.122.148340
https://doi.org/10.1124/jpet.122.148340