Zobrazeno 1 - 10
of 24
pro vyhledávání: '"Zhaleh Ghaemi"'
Publikováno v:
Scientific Reports, Vol 13, Iss 1, Pp 1-13 (2023)
Abstract Despite a vaccine, hepatitis B virus (HBV) remains a world-wide source of infections and deaths. We develop a whole-cell computational platform combining spatial and kinetic models describing the infection cycle of HBV in a hepatocyte host.
Externí odkaz:
https://doaj.org/article/c78f362d17834b94b6129a12f3d38359
Publikováno v:
PLoS Computational Biology, Vol 16, Iss 3, p e1007717 (2020)
Spatial organization is a characteristic of all cells, achieved in eukaryotic cells by utilizing both membrane-bound and membrane-less organelles. One of the key processes in eukaryotes is RNA splicing, which readies mRNA for translation. This comple
Externí odkaz:
https://doaj.org/article/9aec972f272646e5ac42343d6a18fbdd
Publikováno v:
Nucleic Acids Research. 50:8193-8206
The RNA recognition motif (RRM) occurs widely in RNA-binding proteins, but does not always by itself support full binding. For example, it is known that binding of SL1 RNA to the protein U1-70K in the U1 spliceosomal particle is reduced when a region
Autor:
Defne Gorgun, Timothy James Tan, Po-Chao Wen, Martin Frank, Zhaleh Ghaemi, Nicholas C. Wu, Emad Tajkhorshid
Publikováno v:
Biophysical Journal. 122:448a-449a
Despite a vaccine, hepatitis B virus (HBV) remains a world-wide source of infections and deaths, and tackling the infection requires a multimodal approach against the virus. We develop a whole-cell computational platform combining spatial and kinetic
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::6062e49c24bff1cc43c701ce7766c816
https://doi.org/10.1101/2022.06.01.494377
https://doi.org/10.1101/2022.06.01.494377
Publikováno v:
Proc Natl Acad Sci U S A
The disassembly of a viral capsid leading to the release of its genetic material into the host cell is a fundamental step in viral infection. Hepatitis B virus (HBV) in particular consists of identical capsid protein monomers that dimerize and also a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::99c3253773f4c9feefb81b30dd0503b3
https://doi.org/10.1101/2021.02.08.430262
https://doi.org/10.1101/2021.02.08.430262
Publikováno v:
Biophysical Journal. 121:288a
Publikováno v:
Biophysical Journal. 121:168a
Publikováno v:
Journal of Chemical Theory and Computation. 12:4093-4099
The ability of a drug to cross the intestine-blood barrier is a key quantity for drug design and employment and is normally quantified by the permeability coefficient P, often evaluated in the so-called Caco-2 assay. This assay is based on measuring
Publikováno v:
Biophysical Journal. 118:518a