Výsledky vyhledávání

Akademický článek

Loss of PI3Kα Mediates Protection From Myocardial Ischemia–Reperfusion Injury Linked to Preserved Mitochondrial Function

Autor: Pavel Zhabyeyev, Brent McLean, Wesam Bassiouni, Robert Valencia, Manish Paul, Ahmed M. Darwesh, John M. Seubert, Saugata Hazra, Gavin Y. Oudit

Publikováno v: Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, Vol 12, Iss 12 (2023)

Background Identifying new therapeutic targets for preventing the myocardial ischemia–reperfusion injury would have profound implications in cardiovascular medicine. Myocardial ischemia–reperfusion injury remains a major clinical burden in patien

Externí odkaz: https://doaj.org/article/ed1d9a0d30f24e35aea95c55043ad235

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Akademický článek

Amlodipine rescues advanced iron overload cardiomyopathy in hemojuvelin knockout murine model: Clinical implications

Autor: Pavel Zhabyeyev, Chandu Sadasivan, Saumya Shah, Faqi Wang, Gavin Y. Oudit

Publikováno v: Frontiers in Cardiovascular Medicine, Vol 10 (2023)

BackgroundIron overload cardiomyopathy (IOC) is a major co-morbidity of genetic hemochromatosis and secondary iron overload with limited therapeutic options. We aim to investigate mechanisms of rescue action of amlodipine in the murine model of iron

Externí odkaz: https://doaj.org/article/0e1addaa6fdf490cb79b12821c59b2bd

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Akademický článek

Stimulating myocardial pyruvate dehydrogenase activity fails to alleviate cardiac abnormalities in a mouse model of human Barth syndrome

Autor: Amanda A. Greenwell, Seyed Amirhossein Tabatabaei Dakhili, Keshav Gopal, Christina T. Saed, Jordan S. F. Chan, Nick Kazungu Mugabo, Pavel Zhabyeyev, Farah Eaton, Jennifer Kruger, Gavin Y. Oudit, John R. Ussher

Publikováno v: Frontiers in Cardiovascular Medicine, Vol 9 (2022)

Barth syndrome (BTHS) is a rare genetic disorder due to mutations in the TAFAZZIN gene, leading to impaired maturation of cardiolipin and thereby adversely affecting mitochondrial function and energy metabolism, often resulting in cardiomyopathy. In

Externí odkaz: https://doaj.org/article/5408c8de8162435f8fa4dc2704c62e07

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Akademický článek

Small Molecule RPI-194 Stabilizes Activated Troponin to Increase the Calcium Sensitivity of Striated Muscle Contraction

Autor: Zabed Mahmud, Svetlana Tikunova, Natalya Belevych, Cory S. Wagg, Pavel Zhabyeyev, Philip B. Liu, David V. Rasicci, Christopher M. Yengo, Gavin Y. Oudit, Gary D. Lopaschuk, Peter J. Reiser, Jonathan P. Davis, Peter M. Hwang

Publikováno v: Frontiers in Physiology, Vol 13 (2022)

Small molecule cardiac troponin activators could potentially enhance cardiac muscle contraction in the treatment of systolic heart failure. We designed a small molecule, RPI-194, to bind cardiac/slow skeletal muscle troponin (Cardiac muscle and slow

Externí odkaz: https://doaj.org/article/756603ce756d47d9bebb8a3a2a2a53cd

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Akademický článek

PI3Kα-regulated gelsolin activity is a critical determinant of cardiac cytoskeletal remodeling and heart disease

Autor: Vaibhav B. Patel, Pavel Zhabyeyev, Xueyi Chen, Faqi Wang, Manish Paul, Dong Fan, Brent A. McLean, Ratnadeep Basu, Pu Zhang, Saumya Shah, John F. Dawson, W. Glen Pyle, Mousumi Hazra, Zamaneh Kassiri, Saugata Hazra, Bart Vanhaesebroeck, Christopher A. McCulloch, Gavin Y. Oudit

Publikováno v: Nature Communications, Vol 9, Iss 1, Pp 1-14 (2018)

Gelsolin is an actin severing and capping protein that regulates cytoskeletal remodeling. Here the authors show that gelsolin is negatively regulated in the heart by PI3Kα‐ generated PIP3, and that loss of gelsolin activity prevents adverse cytosk

Externí odkaz: https://doaj.org/article/e70a2475a25a49f6b0fbaaaa812f41c8

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Akademický článek

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Akademický článek

PI3Kα Pathway Inhibition With Doxorubicin Treatment Results in Distinct Biventricular Atrophy and Remodeling With Right Ventricular Dysfunction

Autor: Brent A. McLean, Vaibhav B. Patel, Pavel Zhabyeyev, Xueyi Chen, Ratnadeep Basu, Faqi Wang, Saumya Shah, Bart Vanhaesebroeck, Gavin Y. Oudit

Publikováno v: Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, Vol 8, Iss 9 (2019)

Background Cancer therapies inhibiting PI3Kα (phosphoinositide 3‐kinase‐α)–dependent growth factor signaling, including trastuzumab inhibition of HER2 (Human Epidermal Growth Factor Receptor 2), can cause adverse effects on the heart. Direct

Externí odkaz: https://doaj.org/article/93d6993a8a9f47c7bbf681be53362f96

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