The Drosophila homologue of the amyloid precursor protein is a conserved modulator of Wnt PCP signaling.

Autor: Alessia Soldano, Zeynep Okray, Pavlina Janovska, Kateřina Tmejová, Elodie Reynaud, Annelies Claeys, Jiekun Yan, Zeynep Kalender Atak, Bart De Strooper, Jean-Maurice Dura, Vítězslav Bryja, Bassem A Hassan

Publikováno v: PLoS Biology, Vol 11, Iss 5, p e1001562 (2013)

Wnt Planar Cell Polarity (PCP) signaling is a universal regulator of polarity in epithelial cells, but it regulates axon outgrowth in neurons, suggesting the existence of axonal modulators of Wnt-PCP activity. The Amyloid precursor proteins (APPs) ar

Externí odkaz: https://doaj.org/article/3db69bb975404b6395981c87d0f49d1e

Multisensory learning binds modality-specific neurons into a cross-modal memory engram

Autor: Zeynep Okray, Pedro F. Jacob, Ciara Stern, Kieran Desmond, Nils Otto, Paola Vargas-Gutierrez, Scott Waddell

Associating multiple sensory cues with objects and experience is a fundamental brain process that improves object recognition and memory performance. However, neural mechanisms that bind sensory features during learning and augment memory expression

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::19207a386bdc1788dae1993ec1fa5fec
https://doi.org/10.1101/2022.07.08.499174

An opposing self-reinforced odor pre-exposure memory produces latent inhibition in Drosophila

Autor: Pedro F. Jacob, Zeynep Okray, Scott Waddell, Stefania Vietti-Michelina, Johannes Felsenberg, Paola Vargas-Gutierrez

Prior experience of a stimulus can inhibit subsequent acquisition or expression of a learned association of that stimulus. However, the neuronal manifestations of this learning effect, named latent inhibition (LI), are poorly understood. Here we show

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::c18884af04294d378cb67222f5f549fa
https://doi.org/10.1101/2021.02.10.430636

The impact of the gut microbiome on memory and sleep in Drosophila

Autor: Karen L. Adair, John Ewer, Angelina Palacios-Muñoz, Valeria Silva, Scott Waddell, Angela E. Douglas, Zeynep Okray

Publikováno v: Journal of Experimental Biology.

The gut microbiome has been proposed to influence diverse behavioral traits of animals, although the experimental evidence is limited and often contradictory. Here, we make use of the tractability of Drosophila melanogaster for both behavioral analys

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::cc5f6c056ee70ab2a1526c223b6fe24a
https://doi.org/10.1242/jeb.233619

Reduced Lateral Inhibition Impairs Olfactory Computations and Behaviors in a Drosophila Model of Fragile X Syndrome

Autor: Bassem A. Hassan, Gerit A. Linneweber, Zeynep Okray, Luis M. Franco, Emre Yaksi

Publikováno v: Current Biology-CB
Current Biology-CB, 2017, ⟨10.1016/j.cub.2017.02.065⟩
Current Biology
Current Biology-CB, Elsevier, 2017, ⟨10.1016/j.cub.2017.02.065⟩

International audience; Fragile X syndrome (FXS) patients present neuronal alterations that lead to severe intellectual disability, but the underlying neuronal circuit mechanisms are poorly understood. An emerging hypothesis postulates that reduced G

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::52f0a2cf55e0174807e7a058783d3578
https://pubmed.ncbi.nlm.nih.gov/28441561