Zobrazeno 1 - 10
of 36
pro vyhledávání: '"Zeynep Kalender-Atak"'
Autor:
Evelyne Naus, Marleen Derweduwe, Youlia Lampi, Annelies Claeys, Jarne Pauwels, Tobias Langenberg, Filip Claes, Jie Xu, Veerle Haemels, Zeynep Kalender Atak, Rob van der Kant, Joost Van Durme, Greet De Baets, Keith L. Ligon, Mark Fiers, Kris Gevaert, Stein Aerts, Frederic Rousseau, Joost Schymkowitz, Frederik De Smet
Publikováno v:
Cells, Vol 12, Iss 6, p 960 (2023)
In malignant cancer, excessive amounts of mutant p53 often lead to its aggregation, a feature that was recently identified as druggable. Here, we describe that induction of a heat shock-related stress response mediated by Foldlin, a small-molecule to
Externí odkaz:
https://doaj.org/article/37999acd49cb4597b94c46b713bf272c
Autor:
Luis Zurkirchen, Sandra Varum, Sonja Giger, Annika Klug, Jessica Häusel, Raphaël Bossart, Martina Zemke, Claudio Cantù, Zeynep Kalender Atak, Nicola Zamboni, Konrad Basler, Lukas Sommer
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-16 (2019)
The transcription factor Yin Yang 1 (YY1) plays an important role in human disease, yet little is known about its role in brain development. This study shows that YY1 controls cerebral cortex development by maintaining proliferation and survival of n
Externí odkaz:
https://doaj.org/article/bc26cd50490644df85c84964bd1b920a
Autor:
Laura Gadeyne, Yannick Van Herck, Giorgia Milli, Zeynep Kalender Atak, Maddalena Maria Bolognesi, Jasper Wouters, Lukas Marcelis, Angeliki Minia, Vaia Pliaka, Jan Roznac, Leonidas G. Alexopoulos, Giorgio Cattoretti, Oliver Bechter, Joost Van Den Oord, Frederik De Smet, Asier Antoranz, Francesca Maria Bosisio
Publikováno v:
Frontiers in Oncology, Vol 11 (2021)
The emergence of immune checkpoint inhibitors has dramatically changed the therapeutic landscape for patients with advanced melanoma. However, relatively low response rates and a high incidence of severe immune-related adverse events have prompted th
Externí odkaz:
https://doaj.org/article/206ab1bbe50a4eb19b7018688ac2ddd1
Autor:
Zeynep Kalender Atak, Hana Imrichova, Dmitry Svetlichnyy, Gert Hulselmans, Valerie Christiaens, Joke Reumers, Hugo Ceulemans, Stein Aerts
Publikováno v:
Genome Medicine, Vol 9, Iss 1, Pp 1-13 (2017)
Abstract The identification of functional non-coding mutations is a key challenge in the field of genomics. Here we introduce μ-cisTarget to filter, annotate and prioritize cis-regulatory mutations based on their putative effect on the underlying
Externí odkaz:
https://doaj.org/article/16a8687e5b1941109d124dadcf0669a0
Autor:
Karen Verboom, Wouter Van Loocke, Pieter-Jan Volders, Bieke Decaesteker, Francisco Avila Cobos, Simon Bornschein, Charles E. de Bock, Zeynep Kalender Atak, Emmanuelle Clappier, Stein Aerts, Jan Cools, Jean Soulier, Tom Taghon, Pieter Van Vlierberghe, Jo Vandesompele, Frank Speleman, Kaat Durinck
Publikováno v:
Haematologica, Vol 103, Iss 12 (2018)
Externí odkaz:
https://doaj.org/article/20376f51afbd42e3b908c9d13fd65995
Autor:
David Mauduit, Maxime de Waegeneer, Florian Rambow, Dennis Pedri, Jean-Christophe Marine, Samira Makhzami, Carmen Bravo González-Blas, Zeynep Kalender-Atak, Kristofer Davie, Stein Aerts, Ghanem Elias Ghanem, Ahmad Najem, Suresh Poovathingal, Michael Dewaele, Valerie Christiaens, Liesbeth Minnoye, Jasper Wouters, Gert Hulselmans, Frederik Ceyssens, Katina I. Spanier
Publikováno v:
Nature Cell Biology
Melanoma cells can switch between a melanocytic and a mesenchymal-like state. Scattered evidence indicates that additional intermediate state(s) may exist. Here, to search for such states and decipher their underlying gene regulatory network (GRN), w
Publikováno v:
PLoS Computational Biology, Vol 11, Iss 11, p e1004590 (2015)
Cancer genomes contain vast amounts of somatic mutations, many of which are passenger mutations not involved in oncogenesis. Whereas driver mutations in protein-coding genes can be distinguished from passenger mutations based on their recurrence, non
Externí odkaz:
https://doaj.org/article/11086cce95c6426f858f1a455260a575
Autor:
Zeynep Kalender Atak, Jonas Demeulemeester, Ibrahim Ihsan Taskiran, Stein Aerts, Christopher Flerin, Valerie Christiaens, Jasper Wouters, Gert Hulselmans, Ghanem Elias Ghanem, Liesbeth Minnoye, David Mauduit
Publikováno v:
Genome research, 31 (6
Genome Res
Genome Research
Genome Res
Genome Research
Genomic sequence variation within enhancers and promoters can have a significant impact on the cellular state and phenotype. However, sifting through the millions of candidate variants in a personal genome or a cancer genome, to identify those that i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::85d68150a28d624b0c14940612ffdda8
http://hdl.handle.net/2013/ULB-DIPOT:oai:dipot.ulb.ac.be:2013/326913
http://hdl.handle.net/2013/ULB-DIPOT:oai:dipot.ulb.ac.be:2013/326913
Autor:
Rekin's Janky, Annelien Verfaillie, Hana Imrichová, Bram Van de Sande, Laura Standaert, Valerie Christiaens, Gert Hulselmans, Koen Herten, Marina Naval Sanchez, Delphine Potier, Dmitry Svetlichnyy, Zeynep Kalender Atak, Mark Fiers, Jean-Christophe Marine, Stein Aerts
Publikováno v:
PLoS Computational Biology, Vol 10, Iss 7, p e1003731 (2014)
Identifying master regulators of biological processes and mapping their downstream gene networks are key challenges in systems biology. We developed a computational method, called iRegulon, to reverse-engineer the transcriptional regulatory network u
Externí odkaz:
https://doaj.org/article/709d0c14a614436cbd7be589f1fbc7a4
Autor:
Jan Cools, Martina Moretti, Peter Vandenberghe, Paolo Gorello, Giovanni Roti, Renato Bassan, Giovanna De Santis, Rocco Piazza, Nicoletta Testoni, Fabrizia Pellanera, Roberta La Starza, Jean-Pierre Bourquin, Cristina Mecucci, Kim De Keersmaecker, Zeynep Kalender Atak, Christine J. Harrison, Valentina Pierini, Beat Bornhauser, Danika Di Giacomo, Caterina Matteucci, Silvia Arniani, Stein Aerts
Acute leukemias (ALs) of ambiguous lineage are a heterogeneous group of high-risk leukemias characterized by coexpression of myeloid and lymphoid markers. In this study, we identified a distinct subgroup of immature acute leukemias characterized by a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e7f4076a9858b583e4bfae0624e9e774
http://hdl.handle.net/10281/345360
http://hdl.handle.net/10281/345360