Zobrazeno 1 - 10
of 90
pro vyhledávání: '"Zeyad D Nassar"'
Autor:
Zeyad D Nassar, Chui Yan Mah, Jonas Dehairs, Ingrid JG Burvenich, Swati Irani, Margaret M Centenera, Madison Helm, Raj K Shrestha, Max Moldovan, Anthony S Don, Jeff Holst, Andrew M Scott, Lisa G Horvath, David J Lynn, Luke A Selth, Andrew J Hoy, Johannes V Swinnen, Lisa M Butler
Publikováno v:
eLife, Vol 9 (2020)
Fatty acid β-oxidation (FAO) is the main bioenergetic pathway in human prostate cancer (PCa) and a promising novel therapeutic vulnerability. Here we demonstrate therapeutic efficacy of targeting FAO in clinical prostate tumors cultured ex vivo, and
Externí odkaz:
https://doaj.org/article/691410c791b2452584ed62099c163640
Autor:
Nikki L. Raftopulos, Tinashe C. Washaya, Andreas Niederprüm, Antonia Egert, Mariam F. Hakeem-Sanni, Bianca Varney, Atqiya Aishah, Mariya L. Georgieva, Ellinor Olsson, Diandra Z. dos Santos, Zeyad D. Nassar, Blake J. Cochran, Shilpa R. Nagarajan, Meghna S. Kakani, Jordan F. Hastings, David R. Croucher, Kerry-Anne Rye, Lisa M. Butler, Thomas Grewal, Andrew J. Hoy
Publikováno v:
Cancer & Metabolism, Vol 10, Iss 1, Pp 1-15 (2022)
Abstract Background Prostate cancer growth is driven by androgen receptor signaling, and advanced disease is initially treatable by depleting circulating androgens. However, prostate cancer cells inevitably adapt, resulting in disease relapse with in
Externí odkaz:
https://doaj.org/article/e83c402edc4b4083861b68170e431ea4
Autor:
Zina A. Habib-Martin, Hana M. Hammad, Fatma U. Afifi, Malek Zihlif, Hamzeh J. Al-Ameer, Mohanad M. Saleh, Ismail F. Abaza, Zeyad D. Nassar
Publikováno v:
Asian Pacific Journal of Tropical Biomedicine, Vol 7, Iss 8, Pp 732-738 (2017)
Objective: To assess the antiangiogenic activity of fenugreek. Methods: Different fractions of fenugreek crude extracts were prepared and their antiangiogenic properties were assessed using the ex vivo rat aortic ring assay and in vivo chicken embryo
Externí odkaz:
https://doaj.org/article/9fe3c649e59149e78a7b941e3b15b5dc
Autor:
Lisa M. Butler, Andrew J. Hoy, Roger J. Daly, David J. Lynn, Max Moldovan, Shilpa R. Nagarajan, Elizabeth V. Nguyen, Julia S. Scott, Martin C. Sadowski, Swati Irani, Margaret M. Centenera, Chui Yan Mah, Zeyad D. Nassar
Primary antibodies and stains details
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::815e2beaf80029791842d929ddc656aa
https://doi.org/10.1158/1541-7786.22526831
https://doi.org/10.1158/1541-7786.22526831
Autor:
Lisa M. Butler, Andrew J. Hoy, Roger J. Daly, David J. Lynn, Max Moldovan, Shilpa R. Nagarajan, Elizabeth V. Nguyen, Julia S. Scott, Martin C. Sadowski, Swati Irani, Margaret M. Centenera, Chui Yan Mah, Zeyad D. Nassar
HSP90 is a molecular chaperone required for stabilization and activation of hundreds of client proteins, including many known oncoproteins. AUY922 (luminespib), a new-generation HSP90 inhibitor, exhibits potent preclinical efficacy against several ca
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::148e3f539b49f69a09dd3e8e0244a16b
https://doi.org/10.1158/1541-7786.c.6545228.v1
https://doi.org/10.1158/1541-7786.c.6545228.v1
Autor:
Andrew J. Hoy, Lisa M. Butler, Lisa G. Horvath, Jeff Holst, Darren N. Saunders, Meghna S. Kakani, Nikki L. Raftopulos, Rae-Anne Hardie, Robert F. Shearer, Shilpa R. Nagarajan, Lisa S. Lee, Frank Liu-Fu, Bianca Varney, Atqiya Aishah, Hui-Ming Lin, Mark Schreuder, Margaret M. Centenera, Elham Hosseini-Beheshti, Alison Y. Zhang, Zeyad D. Nassar, Seher Balaban
S1: Pretreatment of PC-3 and C4-2B cells with a FA Mix alters the response to palmitate lipotoxicity and serum-starvation. S2: Dose response assessment of palmitate supplementation on cell viability. S3: Pretreatment with the DGAT1 inhibitor AZD3988
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::73170f582eb49a3293a5afcb6456b8e5
https://doi.org/10.1158/1541-7786.22512309.v1
https://doi.org/10.1158/1541-7786.22512309.v1
Autor:
Lisa M. Butler, Andrew J. Hoy, Roger J. Daly, David J. Lynn, Max Moldovan, Shilpa R. Nagarajan, Elizabeth V. Nguyen, Julia S. Scott, Martin C. Sadowski, Swati Irani, Margaret M. Centenera, Chui Yan Mah, Zeyad D. Nassar
Figure S1. AUY922 treatment induces the expression of proteins involved in fatty acid. metabolism and increases PCa cell mitochondrial mass and cellular ROS. Figure S2. Combination treatment of AUY922 with antagonists of fatty acid oxidation (FAO) an
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6911aa9fae68ba4a88053d0b4bdc8af6
https://doi.org/10.1158/1541-7786.22526834.v1
https://doi.org/10.1158/1541-7786.22526834.v1
Autor:
Andrew J. Hoy, Lisa M. Butler, Lisa G. Horvath, Jeff Holst, Darren N. Saunders, Meghna S. Kakani, Nikki L. Raftopulos, Rae-Anne Hardie, Robert F. Shearer, Shilpa R. Nagarajan, Lisa S. Lee, Frank Liu-Fu, Bianca Varney, Atqiya Aishah, Hui-Ming Lin, Mark Schreuder, Margaret M. Centenera, Elham Hosseini-Beheshti, Alison Y. Zhang, Zeyad D. Nassar, Seher Balaban
Prostate cancer cells exhibit altered cellular metabolism but, notably, not the hallmarks of Warburg metabolism. Prostate cancer cells exhibit increased de novo synthesis of fatty acids (FA); however, little is known about how extracellular FAs, such
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::044e3d871558d96a3327f380e00756f5
https://doi.org/10.1158/1541-7786.c.6540204.v1
https://doi.org/10.1158/1541-7786.c.6540204.v1
Autor:
Johannes V. Swinnen, Margaret M. Centenera, Lisa G. Horvath, Wayne D. Tilley, David J. Lynn, Marten F. Snel, Paul J. Trim, Luke A. Selth, Zeyad D. Nassar, Etienne Waelkens, Rita Derua, Thomas Gevaert, James G. Kench, Jurgen Stahl, Rajdeep Das, Katarzyna Bloch, Frank Vanderhoydonc, Jonas Dehairs, Max Moldovan, David Waltregny, Muralidhararao Bagadi, Xander Spotbeen, Shadrack M. Mutuku, Swati Irani, Andrew D. Vincent, Jelle Machiels, Chui Yan Mah, Lisa M. Butler
Results of lipid association analyses
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2cf809a0c68942e4c775b65a6f0f125b
https://doi.org/10.1158/0008-5472.22428964.v1
https://doi.org/10.1158/0008-5472.22428964.v1
Autor:
Johannes V. Swinnen, Margaret M. Centenera, Lisa G. Horvath, Wayne D. Tilley, David J. Lynn, Marten F. Snel, Paul J. Trim, Luke A. Selth, Zeyad D. Nassar, Etienne Waelkens, Rita Derua, Thomas Gevaert, James G. Kench, Jurgen Stahl, Rajdeep Das, Katarzyna Bloch, Frank Vanderhoydonc, Jonas Dehairs, Max Moldovan, David Waltregny, Muralidhararao Bagadi, Xander Spotbeen, Shadrack M. Mutuku, Swati Irani, Andrew D. Vincent, Jelle Machiels, Chui Yan Mah, Lisa M. Butler
Supplementary Figures S1-S6
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::55b89972cab90e3a0c804a03e7cfba5a
https://doi.org/10.1158/0008-5472.22428970
https://doi.org/10.1158/0008-5472.22428970