Zobrazeno 1 - 10
of 4 679
pro vyhledávání: '"Zexuan"'
Autor:
Jianbang Lin, Jing Liu, Qi Zhang, Taian Liu, Zexuan Hong, Yi Lu, Cheng Zhong, Zhonghua Lu, Yuantao Li, Yu Hu
Publikováno v:
Molecular Brain, Vol 17, Iss 1, Pp 1-11 (2024)
Abstract Temporal lobe epilepsy (TLE) is the most common form of medically-intractable epilepsy. Subicular hyperexcitability is frequently observed with TLE, presumably caused by impaired inhibition of local excitatory neurons. Here, we evaluated the
Externí odkaz:
https://doaj.org/article/0cad844d461341f0a6f45915b5d96f24
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-14 (2024)
Abstract Structure-based machine learning algorithms have been utilized to predict the properties of protein-protein interaction (PPI) complexes, such as binding affinity, which is critical for understanding biological mechanisms and disease treatmen
Externí odkaz:
https://doaj.org/article/58efcb3b577b42d5bc3ea273c6d79174
Autor:
Clare E. Murray, Anand V. R. Kornepati, Carlos Ontiveros, Yiji Liao, Bárbara de la Peña Avalos, Cody M. Rogers, Zexuan Liu, Yilun Deng, Haiyan Bai, Suresh Kari, Alvaro S. Padron, Jacob T. Boyd, Ryan Reyes, Curtis A. Clark, Robert S. Svatek, Rong Li, Yanfen Hu, Meiling Wang, José R. Conejo-Garcia, Lauren A. Byers, Kavya Ramkumar, Anil K. Sood, Jung-Min Lee, Christin E. Burd, Ratna K. Vadlamudi, Harshita B. Gupta, Weixing Zhao, Eloïse Dray, Patrick Sung, Tyler J. Curiel
Publikováno v:
Molecular Cancer, Vol 23, Iss 1, Pp 1-24 (2024)
Abstract Background Aside from the canonical role of PDL1 as a tumour surface-expressed immune checkpoint molecule, tumour-intrinsic PDL1 signals regulate non-canonical immunopathological pathways mediating treatment resistance whose significance, me
Externí odkaz:
https://doaj.org/article/324b033e9fa34bbcab45721b8054a03a
Publikováno v:
BioData Mining, Vol 17, Iss 1, Pp 1-29 (2024)
Abstract Background The rapid growth of deep learning, as well as the vast and ever-growing amount of available data, have provided ample opportunity for advances in fusion and analysis of complex and heterogeneous data types. Different data modaliti
Externí odkaz:
https://doaj.org/article/3d52f810c1654bd5b733175b213b9f65
Autor:
Xue Yang, Zexuan Liu, Weiwei Tang, Uday P. Pratap, Alexia B. Collier, Kristin A. Altwegg, Rahul Gopalam, Xiaonan Li, Yaxia Yuan, Daohong Zhou, Zhao Lai, Yidong Chen, Gangadhara R. Sareddy, Philip T. Valente, Edward R. Kost, Suryavathi Viswanadhapalli, Ratna K. Vadlamudi
Publikováno v:
Molecular Oncology, Vol 18, Iss 9, Pp 2136-2156 (2024)
Endometrial carcinoma (ECa) is the fourth most common cancer among women. The oncogene PELP1 is frequently overexpressed in a variety of cancers, including ECa. We recently generated SMIP34, a small‐molecule inhibitor of PELP1 that suppresses PELP1
Externí odkaz:
https://doaj.org/article/004752a72a024ab7b87a815d9b033c3e
Autor:
Yukai Wang, Shaoqi Chen, Shaoyu Zheng, Zexuan Zhou, Weijin Zhang, Guangzhou Du, Angelina Mikish, Barbara Ruaro, Cosimo Bruni, Anna-Maria Hoffmann-Vold, Luna Gargani, Marco Matucci-Cerinic, Daniel E Furst
Publikováno v:
Arthritis Research & Therapy, Vol 26, Iss 1, Pp 1-11 (2024)
Abstract Systemic autoimmune rheumatic diseases (SARDs) related pulmonary disease is highly prevalent, with variable clinical presentation and behavior, and thus is associated with poor outcomes and negatively impacts quality of life. Chest high reso
Externí odkaz:
https://doaj.org/article/df30442c4ebe4e88999340266017ada4
Autor:
Fangshu Liu, Xiaofan Sun, Suqi Deng, Yingying Wu, Xingcheng Liu, Caiping Wu, Kexiu Huang, Yue Li, Zexuan Dong, Weihao Xiao, Manchun Li, Zhiyang Chen, Zhenyu Ju, Jia Xiao, Juan Du, Hui Zeng
Publikováno v:
Stem Cell Research & Therapy, Vol 15, Iss 1, Pp 1-13 (2024)
Abstract Background The function of hematopoietic stem cells (HSC) is regulated by HSC internal signaling pathways and their microenvironment. Chemokines and chemokine ligands play important roles in the regulation of HSC function. Yet, their functio
Externí odkaz:
https://doaj.org/article/9c34e27f5169431ca7ec244444d600ba
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-19 (2024)
Abstract In order to further promote the application of cementitious sand gravel (CSG), the mechanical properties and variation rules of CSG material under triaxial test were studied. Considering the influence of fly ash content, water-binder ratio,
Externí odkaz:
https://doaj.org/article/442f692110884438bfb5fec7fef32be5
Publikováno v:
Diabetology & Metabolic Syndrome, Vol 16, Iss 1, Pp 1-15 (2024)
Abstract Background There is ongoing debate on the correlation between chronic kidney disease (CKD) and insulin resistance (IR)-related indices. Our objective was to explore the prognostic ability of IR-related indexes for the prevalence of CKD, as w
Externí odkaz:
https://doaj.org/article/59f877b6e6c64231b81fce6d5aba496c
Evolution and comparative transcriptome analysis of glucosinolate pathway genes in Brassica napus L.
Autor:
Shiying Liu, Zexuan Wu, Xingying Chen, Zhuo Chen, Yibing Shen, Salman Qadir, Huafang Wan, Huiyan Zhao, Nengwen Yin, Jiana Li, Cunmin Qu, Hai Du
Publikováno v:
Frontiers in Plant Science, Vol 15 (2024)
Glucosinolates (GSLs) are important secondary metabolites abundantly distributed in Brassicaceae plants, whose degradation products benefit plant resistance but are regarded as disadvantageous factors for human health. Thus, reducing GSL content is a
Externí odkaz:
https://doaj.org/article/769d54c0719c4e058ecc02b8ba515bb1