Zobrazeno 1 - 10
of 59
pro vyhledávání: '"Zewen K, Tuong"'
Autor:
Colin Y. C. Lee, Bethany C. Kennedy, Nathan Richoz, Isaac Dean, Zewen K. Tuong, Fabrina Gaspal, Zhi Li, Claire Willis, Tetsuo Hasegawa, Sarah K. Whiteside, David A. Posner, Gianluca Carlesso, Scott A. Hammond, Simon J. Dovedi, Rahul Roychoudhuri, David R. Withers, Menna R. Clatworthy
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-18 (2024)
Abstract Tumour dendritic cells (DCs) internalise antigen and upregulate CCR7, which directs their migration to tumour-draining lymph nodes (dLN). CCR7 expression is coupled to an activation programme enriched in regulatory molecule expression, inclu
Externí odkaz:
https://doaj.org/article/a9dead2996844a5bb3e43c7e6aa7f935
Rapid functional impairment of natural killer cells following tumor entry limits anti-tumor immunity
Autor:
Isaac Dean, Colin Y. C. Lee, Zewen K. Tuong, Zhi Li, Christopher A. Tibbitt, Claire Willis, Fabrina Gaspal, Bethany C. Kennedy, Veronika Matei-Rascu, Rémi Fiancette, Caroline Nordenvall, Ulrik Lindforss, Syed Murtuza Baker, Christian Stockmann, Veronika Sexl, Scott A. Hammond, Simon J. Dovedi, Jenny Mjösberg, Matthew R. Hepworth, Gianluca Carlesso, Menna R. Clatworthy, David R. Withers
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-18 (2024)
Abstract Immune cell dysfunction within the tumor microenvironment (TME) undermines the control of cancer progression. Established tumors contain phenotypically distinct, tumor-specific natural killer (NK) cells; however, the temporal dynamics, mecha
Externí odkaz:
https://doaj.org/article/27d36aa7031e441daba36d10fc106a98
Autor:
Ondrej Suchanek, John R. Ferdinand, Zewen K. Tuong, Sathi Wijeyesinghe, Anita Chandra, Ann-Katrin Clauder, Larissa N. Almeida, Simon Clare, Katherine Harcourt, Christopher J. Ward, Rachael Bashford-Rogers, Trevor Lawley, Rudolf A. Manz, Klaus Okkenhaug, David Masopust, Menna R. Clatworthy
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-20 (2023)
Abstract B cells play a central role in humoral immunity but also have antibody-independent functions. Studies to date have focused on B cells in blood and secondary lymphoid organs but whether B cells reside in non-lymphoid organs (NLO) in homeostas
Externí odkaz:
https://doaj.org/article/c0d8e43c40604f7b822a7676214f0253
Autor:
Nathan Richoz, Zewen K. Tuong, Kevin W. Loudon, Eduardo Patiño-Martínez, John R. Ferdinand, Jorge Romo-Tena, Anaïs Portet, Kathleen R. Bashant, Emeline Thevenon, Francesca Rucci, Thomas Hoyler, Tobias Junt, Mariana J. Kaplan, Richard M. Siegel, Menna R. Clatworthy
Publikováno v:
JCI Insight, Vol 7, Iss 21 (2023)
Lupus nephritis is a serious complication of systemic lupus erythematosus, mediated by IgG immune complex (IC) deposition in kidneys, with limited treatment options. Kidney macrophages are critical tissue sentinels that express IgG-binding Fcγ recep
Externí odkaz:
https://doaj.org/article/d738063f70d840b2bb17022567be68e4
Autor:
Hao Kang, Hongjian Sun, Yang Yang, Zewen K Tuong, Minglei Shu, Yunbo Wei, Yu Zhang, Di Yu, Yong Tao
Publikováno v:
Clinical & Translational Immunology, Vol 12, Iss 9, Pp n/a-n/a (2023)
Abstract Objectives Non‐infectious uveitis is often secondary to systemic autoimmune diseases, with Behçet's disease (BD) and Vogt‐Koyanagi‐Harada disease (VKHD) as the two most common causes. Uveitis in BD and VKHD can show similar clinical m
Externí odkaz:
https://doaj.org/article/b64e68c774234d9abdc73dba3f547338
Autor:
Annika Krueger, Julian Zaugg, Sarah Chisholm, Richard Linedale, Nancy Lachner, Siok Min Teoh, Zewen K. Tuong, Samuel W. Lukowski, Mark Morrison, H. Peter Soyer, Philip Hugenholtz, Michelle M. Hill, Ian H. Frazer
Publikováno v:
Frontiers in Microbiology, Vol 12 (2022)
Squamous cell carcinoma (SCC) is a common type of skin cancer that typically arises from premalignant precursor lesions named actinic keratoses (AK). Chronic inflammation is a well-known promoter of skin cancer progression. AK and SCC have been assoc
Externí odkaz:
https://doaj.org/article/a99987d820cf428b85ddd6179a0a0996
Autor:
Zewen K. Tuong, Samuel W. Lukowski, Quan H. Nguyen, Janin Chandra, Chenhao Zhou, Kevin Gillinder, Abate A. Bashaw, John R. Ferdinand, Benjamin J. Stewart, Siok Min Teoh, Sarah J. Hanson, Katharina Devitt, Menna R. Clatworthy, Joseph E. Powell, Ian H. Frazer
Publikováno v:
iScience, Vol 24, Iss 11, Pp 103326- (2021)
Summary: Langerhans cells (LC) are skin-resident antigen-presenting cells that regulate immune responses to epithelial microorganisms. Human papillomavirus (HPV) infection can promote malignant epithelial transformation. As LCs are considered importa
Externí odkaz:
https://doaj.org/article/08f0ec2087624af0b1807e9af63d460a
Publikováno v:
Papillomavirus Research, Vol 4, Iss , Pp 58-65 (2017)
High-risk human papillomaviruses (HR-HPV) infect basal keratinocytes, where in some individuals they evade host immune responses and persist. Persistent HR-HPV infection of the cervix causes precancerous neoplasia that can eventuate in cervical cance
Externí odkaz:
https://doaj.org/article/0b900bd4fc4c4a98bcb95d79d69657f0
Autor:
Zhen Zeng, Margaret Veitch, Gabrielle A. Kelly, Zewen K. Tuong, Jazmina G. Cruz, Ian H. Frazer, James W. Wells
Publikováno v:
Cancers, Vol 13, Iss 9, p 2131 (2021)
Ultraviolet (UV) radiation-induced tumours carry a high mutational load, are highly immunogenic, and often fail to grow when transplanted into normal, syngeneic mice. The aim of this study was to investigate factors critical for the immune-mediated r
Externí odkaz:
https://doaj.org/article/840e94e4583d4a3ba2748af68557c14d
Autor:
Paula Kuo, Siok Min Teoh, Zewen K. Tuong, Graham R. Leggatt, Stephen R. Mattarollo, Ian H. Frazer
Publikováno v:
Frontiers in Immunology, Vol 9 (2018)
“High-risk” human papillomaviruses (HPV) infect keratinocytes of squamous epithelia. The HPV16E7 protein induces epithelial hyperplasia by binding Rb family proteins and disrupting cell cycle termination. Murine skin expressing HPV16E7 as a trans
Externí odkaz:
https://doaj.org/article/f05b254db92b49cf9964ecaad319d9a0