Zobrazeno 1 - 10
of 25
pro vyhledávání: '"Zeruesenay D"'
Autor:
Jeffrey R. Strawn, Ethan A. Poweleit, Zachary L. Taylor, Tomoyuki Mizuno, Samuel Vaughn, Zeruesenay Desta, Stephani Stancil, Laura B. Ramsey
Publikováno v:
Journal of Clinical and Translational Science, Vol 8, Pp 22-23 (2024)
OBJECTIVES/GOALS: Developing pharmacokinetic (PK) models to guide selective serotonin reuptake inhibitor (SSRI) dosing in youth is costly, time-intensive, and requires large numbers of participants. We evaluated the use of remnant blood samples from
Externí odkaz:
https://doaj.org/article/e1d8503c9362423ea58b12fa2f44074f
Autor:
Nicholas R. Powell, Tiebing Liang, Joseph Ipe, Sha Cao, Todd C. Skaar, Zeruesenay Desta, Hui-Rong Qian, Philip J. Ebert, Yu Chen, Melissa K. Thomas, Naga Chalasani
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-16 (2023)
This study characterizes expression of pharmacogenes across the histological NAFLD severity spectrum. Here, the authors show the downregulation of CYP2C19 in NAFLD which supports developing personalized medicine approaches for drugs sensitive to meta
Externí odkaz:
https://doaj.org/article/a90be45cc8cb455db34c7afe0b5d1181
Publikováno v:
Journal of Drug Metabolism & Toxicology.
17-hydroexemestane is the major metabolite of exemestane in vivo. Previous studies have shown that 17-hydroexemestane is androgenic and bone protective. Due to structure similarities, we hypothesized that, like exemestane, 17-hydroexemestane is an in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::dd54632c765cfd78ffef387a2f8ec362
https://doi.org/10.4172/2157-7609.1000171
https://doi.org/10.4172/2157-7609.1000171
Autor:
Amy L Slogrove, Kara Wools-Kaloustian, Patrick O Monahan, John M Humphrey, Wanzhu Tu, Winstone Nyandiko, Edwin Were, Rachel Vreeman, Eren Oyungu, Ola El Kebbi, Alka Khaitan, Zeruesenay Desta, Rena C Patel, James G Carlucci, Megan S McHenry
Publikováno v:
BMJ Open, Vol 12, Iss 4 (2022)
Introduction For the growing number of children with in utero and postpartum exposure to HIV and/or antiretrovirals, it is unclear which exposures or risk factors play a significant role in predicting worse neurodevelopmental outcomes. This protocol
Externí odkaz:
https://doaj.org/article/a7b3f632735649a4846d5a3bffb05260
Publikováno v:
CPT: Pharmacometrics & Systems Pharmacology, Vol 9, Iss 1, Pp 40-47 (2020)
Multiple doses of tenofovir disoproxil fumarate (TDF) together with emtricitabine is effective for HIV preexposure prophylaxis (PrEP). TDF is converted to tenofovir (TFV) in circulation, which is subsequently cleared via tubular secretion by organic
Externí odkaz:
https://doaj.org/article/42017aa69bcb4f1e8e691c66b3c7ceec
Autor:
Ingrid F. Metzger, Nimita Dave, Yvonne Kreutz, Jessica B.L. Lu, Raymond E. Galinsky, Zeruesenay Desta
Publikováno v:
Clinical and Translational Science, Vol 12, Iss 6, Pp 657-666 (2019)
We investigated the effect of efavirenz on the activities of cytochrome P450 (CYP)1A2, CYP2A6, xanthine oxidase (XO), and N‐acetyltransferase 2 (NAT2), using caffeine as a probe. A single 150 mg oral dose of caffeine was administered to healthy vol
Externí odkaz:
https://doaj.org/article/7529edd957bc4f2184d1d7a88cc6c1c1
Akademický článek
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Akademický článek
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Autor:
Ingrid F. Metzger, PhD, Troy C. Quigg, MD, Noam Epstein, Abdulateef O. Aregbe, MD, Nancy Thong, John T. Callaghan, MD, PhD, David A. Flockhart, MD, PhD, Anne T. Nguyen, Colleen K. Stevens, Samir K. Gupta, Zeruesenay Desta, PhD
Publikováno v:
Current Therapeutic Research, Vol 76, Iss C, Pp 64-69 (2014)
Background: Efavirenz exhibits multiple interactions with drug-metabolizing enzymes and transporters, and for this reason efavirenz-based HIV therapy is associated with altered pharmacokinetics of coadministered drugs. Probably by the same mechanism,
Externí odkaz:
https://doaj.org/article/5952c64f1d9647cc8c4e8f9919cc8ce8
Publikováno v:
Journal of Pharmacy and Pharmacology; November 1992, Vol. 44 Issue: 11 p893-897, 5p