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Publikováno v: Wu, Jian; Zern, M A; & Nolta, Jan A.(2011). Epithelial mesenchymal transition and hedgehog signaling activation are associated with chemoresistance and invasion of hepatoma subpopulations.. Journal of hepatology, 55(4), 838-845. doi: 10.1016/j.jhep.2010.12.043. UC Davis: Retrieved from: http://www.escholarship.org/uc/item/7jb6542v

BACKGROUND & AIMS: Our previous studies showed that CD133, EpCAM, and aldehyde dehydrogenase (ALDH) are useful markers to identify cancer stem cells (CSCs) in hepatocellular carcinoma (HCC) tissues. The present study aims to evaluate chemosensitivity

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=od_______325::20593d1d4788d47ccc8dcacc58da2ddc
http://www.escholarship.org/uc/item/7jb6542v

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Acute liver injury upregulates microRNA-491-5p in mice, and its overexpression sensitizes Hep G2 cells for tumour necrosis factor-alpha-induced apoptosis

Autor: Wu, Jian, Zern, M A

Publikováno v: Wu, Jian; & Zern, M A. (2010). Acute liver injury upregulates microRNA-491-5p in mice, and its overexpression sensitizes Hep G2 cells for tumour necrosis factor-alpha-induced apoptosis.. Liver international : official journal of the International Association for the Study of the Liver, 30(3), 376-387. doi: DOI: 10.1111/j.1478-3231.2009.02181.x. UC Davis: Retrieved from: http://www.escholarship.org/uc/item/65q5d6t0

BACKGROUND: MicroRNAs (miRNAs) have emerged as novel genetic regulators of cell functions such as proliferation, apoptosis and cancer. AIMS: The aim of this study was to evaluate the role of a specific miRNA in modulating hepatic cell functions. Meth

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=od_______325::e106abd127389dd3effd9a2043a6b03c
http://www.escholarship.org/uc/item/65q5d6t0

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Liver fibrosis causes downregulation of miRNA-150 and miRNA-194 in hepatic stellate cells, and their overexpression causes decreased stellate cell activation

Autor: Wu, Jian, Zern, M A

Publikováno v: Wu, Jian; & Zern, M A. (2010). Liver fibrosis causes downregulation of miRNA-150 and miRNA-194 in hepatic stellate cells, and their overexpression causes decreased stellate cell activation.. American journal of physiology. Gastrointestinal and liver physiology, 298(1), 101-106. doi: 10.1152/ajpgi.00220.2009. UC Davis: Retrieved from: http://www.escholarship.org/uc/item/6qk5c3nx

Activation of hepatic stellate cells (HSC) results in their proliferation and in the secretion of extracellular matrix (ECM) proteins, which leads to hepatic fibrosis. microRNAs (miRNAs) have been shown to regulate various cell functions, such as pro

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=od_______325::abd1735ab0e8702ec93c1d05a879ff2c
http://www.escholarship.org/uc/item/6qk5c3nx

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The differentiation of hepatocyte-like cells from monkey embryonic stem cells

Autor: Ma, XiaoCui, Wu, Jian, Zern, M A

Publikováno v: Ma, XiaoCui; Wu, Jian; & Zern, M A. (2008). The differentiation of hepatocyte-like cells from monkey embryonic stem cells.. Cloning and stem cells, 10(4), 485-493. doi: 10.1089/clo.2007.0012.. UC Davis: Retrieved from: http://www.escholarship.org/uc/item/4q3896z1

Embryonic stem cells (ESC) hold great potential for the treatment of liver diseases. Here, we report the differentiation of rhesus macaque ESC along a hepatocyte lineage. The undifferentiated monkey ESC line, ORMES-6, was cultured in an optimal cultu

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=od_______325::724f1ddcee38df88488d8ac38ff40c76
http://www.escholarship.org/uc/item/4q3896z1

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Liposome-mediated extracellular superoxide dismutase gene delivery protects against acute liver injury in mice

Autor: Wu, Jian, Liu, L, Yen, R D, Catana, A, Nantz, M H, Zern, M A

Publikováno v: Wu, Jian; Liu, L; Yen, R D; Catana, A; Nantz, M H; & Zern, M A. (2004). Liposome-mediated extracellular superoxide dismutase gene delivery protects against acute liver injury in mice. Hepatology, 40(1), 195-204. UC Davis: Retrieved from: http://www.escholarship.org/uc/item/7h75n0cw

Our previous study demonstrated that polycationic liposomes are highly stable in the bloodstream and represent an effective agent for liver gene delivery. We report here that liposome-mediated extracellular superoxide dismutase (EC-SOD) gene delivery

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=od_______325::43a85028d53de123cf089144b64c5858
http://www.escholarship.org/uc/item/7h75n0cw

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