Zobrazeno 1 - 10
of 32
pro vyhledávání: '"Zerin Alimajstorovic"'
Autor:
James L Mitchell, Rebecca Buckham, Hannah Lyons, Jessica K Walker, Andreas Yiangou, Matilde Sassani, Mark Thaller, Olivia Grech, Zerin Alimajstorovic, Marianne Julher, Georgios Tsermoulas, Kristian Brock, Susan P Mollan, Alexandra J Sinclair
Publikováno v:
Fluids and Barriers of the CNS, Vol 19, Iss 1, Pp 1-11 (2022)
Abstract Objectives Intracranial pressure (ICP) has been thought to vary diurnally. This study evaluates diurnal ICP measurements and quantifies changes in ICP occurring with changes in body posture in active idiopathic intracranial hypertension (IIH
Externí odkaz:
https://doaj.org/article/a265e97053aa4ab2852bb22ebdd0f478
Autor:
Zerin Alimajstorovic, Ester Pascual-Baixauli, Cheryl A. Hawkes, Basil Sharrack, A. Jane Loughlin, Ignacio A. Romero, Jane E. Preston
Publikováno v:
Fluids and Barriers of the CNS, Vol 17, Iss 1, Pp 1-10 (2020)
Abstract Background Idiopathic intracranial hypertension (IIH) is a neurological disorder characterised by raised cerebrospinal fluid (CSF) pressure in the absence of any intracranial pathology. IIH mainly affects women with obesity between the ages
Externí odkaz:
https://doaj.org/article/5459b6a10cef4547b7909c2798c68e8d
Autor:
Connar S.J. Westgate, Hannah F. Botfield, Zerin Alimajstorovic, Andreas Yiangou, Mark Walsh, Gabrielle Smith, Rishi Singhal, James L. Mitchell, Olivia Grech, Keira A. Markey, Daniel Hebenstreit, Daniel A. Tennant, Jeremy W. Tomlinson, Susan P. Mollan, Christian Ludwig, Ildem Akerman, Gareth G. Lavery, Alexandra J. Sinclair
Publikováno v:
JCI Insight, Vol 6, Iss 10 (2021)
BACKGROUND Idiopathic intracranial hypertension (IIH) is a condition predominantly affecting obese women of reproductive age. Recent evidence suggests that IIH is a disease of metabolic dysregulation, androgen excess, and an increased risk of cardiov
Externí odkaz:
https://doaj.org/article/ad869628076c4e20ba99df429a35f377
Autor:
Clare Mills, Sandra A. Hemkemeyer, Zerin Alimajstorovic, Chantelle Bowers, Malihe Eskandarpour, John Greenwood, Virginia Calder, A. W. Edith Chan, Paul J. Gane, David L. Selwood, Karl Matter, Maria S. Balda
Publikováno v:
Cells, Vol 11, Iss 11, p 1733 (2022)
Inflammation and fibrosis are important components of diseases that contribute to the malfunction of epithelia and endothelia. The Rho guanine nucleotide exchange factor (GEF) GEF-H1/ARHGEF-2 is induced in disease and stimulates inflammatory and fibr
Externí odkaz:
https://doaj.org/article/0936817314424d6bbc31162cfa0c23ff
Autor:
Magda Aguiar, Emma Frew, Susan P. Mollan, James L. Mitchell, Ryan S. Ottridge, Zerin Alimajstorovic, Andreas Yiangou, Rishi Singhal, Abd A. Tahrani, Alex J. Sinclair
Publikováno v:
Life, Vol 11, Iss 5, p 409 (2021)
Background: The Idiopathic Intracranial Hypertension Weight Trial (IIH:WT) established the efficacy of bariatric surgery as compared to a community weight management intervention in reducing intracranial pressure in active IIH. The aim of this cost-e
Externí odkaz:
https://doaj.org/article/b9f56e8cbb674fad96650ecedc0eb763
The effect of GLP-1RA exenatide on idiopathic intracranial hypertension: a randomized clinical trial
Autor:
James L Mitchell, Hannah S Lyons, Jessica K Walker, Andreas Yiangou, Olivia Grech, Zerin Alimajstorovic, Nigel H Greig, Yazhou Li, Georgios Tsermoulas, Kristian Brock, Susan P Mollan, Alexandra J Sinclair
Publikováno v:
Brain. 146:1821-1830
Therapeutics to reduce intracranial pressure are an unmet need. Preclinical data have demonstrated a novel strategy to lower intracranial pressure using glucagon-like peptide-1 (GLP-1) receptor signalling. Here, we translate these findings into patie
Autor:
Cristina Gómez Castella, Zerin Alimajstorovic, Nantia Othonos, Denise Winter, Sarah White, Gareth Lavery, Jeremy Tomlinson, Alexandra J. Sinclair, Alex Odermatt
Background and Purpose: 11β-hydroxysteroid dehydrogenase 1 (11β-HSD1) catalyzes the oxoreduction of cortisone to cortisol, thereby amplifying levels of active glucocorticoids. It is considered a pharmaceutical target in metabolic disease and cognit
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::41d71bc8854685d655c6b3fdada603e5
https://doi.org/10.22541/au.168199029.96895956/v1
https://doi.org/10.22541/au.168199029.96895956/v1
Autor:
Zerin Alimajstorovic, Susan P. Mollan, Olivia Grech, James L. Mitchell, Andreas Yiangou, Mark Thaller, Hannah Lyons, Matilde Sassani, Senali Seneviratne, Thomas Hancox, Andris Jankevics, Lukáš Najdekr, Warwick Dunn, Alexandra J. Sinclair
Publikováno v:
Journal of proteome research.
Autor:
Mark Thaller, Ryan S Ottridge, James L Mitchell, Gareth G. Lavery, Benjamin R Wakerley, Zerin Alimajstorovic, Alex J. Sinclair, Olivia Grech, Kristian Brock, Susan P Mollan, A Gupta, Andreas Yiangou
Publikováno v:
The Journal of Headache and Pain, Vol 22, Iss 1, Pp 1-9 (2021)
The Journal of Headache and Pain
The Journal of Headache and Pain
Objective Headache is the predominant disabler in idiopathic intracranial hypertension (IIH). The aim was to characterise headache and investigate the association with intracranial pressure. Methods IIH:WT was a randomised controlled parallel group m
Autor:
Olivia, Grech, Senali Y, Seneviratne, Zerin, Alimajstorovic, Andreas, Yiangou, James L, Mitchell, Thomas B, Smith, Susan P, Mollan, Gareth G, Lavery, Christian, Ludwig, Alexandra Jean, Sinclair
Publikováno v:
Neurology.
Background and Objective:We evaluated the metabolomic profile in CSF, serum and urine of participants with idiopathic intracranial hypertension (IIH) compared to controls and measured changes in metabolism associated with clinical markers of disease