Zobrazeno 1 - 7
of 7
pro vyhledávání: '"Zeribe Chike Nwosu"'
Autor:
Weronika Piorońska, Zeribe Chike Nwosu, Mei Han, Michael Büttner, Matthias Philip Ebert, Steven Dooley, Christoph Meyer
Publikováno v:
BMC Cancer, Vol 21, Iss 1, Pp 1-16 (2021)
Abstract Background Hepatocellular carcinoma (HCC) is a major cause of cancer-related death. Paired related homeobox 1 (PRRX1) is a transcription factor that regulates cell growth and differentiation, but its importance in HCC is unclear. Methods We
Externí odkaz:
https://doaj.org/article/824da44e3b2046a187e82c21b1ee0ad8
Autor:
Zeribe Chike Nwosu, Weronika Piorońska, Nadia Battello, Andreas David Zimmer, Bedair Dewidar, Mei Han, Sharon Pereira, Biljana Blagojevic, Darko Castven, Verodia Charlestin, Pavlo Holenya, Julia Lochead, Carolina De La Torre, Norbert Gretz, Peter Sajjakulnukit, Li Zhang, Matthew H. Ward, Jens U. Marquardt, Marina Pasca di Magliano, Costas A. Lyssiotis, Jonathan Sleeman, Stefan Wölfl, Matthias Philip Ebert, Christoph Meyer, Ute Hofmann, Steven Dooley
Publikováno v:
EBioMedicine, Vol 54, Iss , Pp - (2020)
Background: The extracellular signal-regulated kinase (ERK) pathway regulates cell growth, and is hyper-activated and associated with drug resistance in hepatocellular carcinoma (HCC). Metabolic pathways are profoundly dysregulated in HCC. Whether an
Externí odkaz:
https://doaj.org/article/383d5f40c0a84df0afc5bf27b396bda2
Autor:
Mei Han, Zeribe Chike Nwosu, Weronika Piorońska, Matthias Philip Ebert, Steven Dooley, Christoph Meyer
Publikováno v:
Frontiers in Physiology, Vol 10 (2020)
Caveolin-1 (CAV1) is a membrane protein associated with metabolism in various cell types. The transforming growth factor beta (TGF-β) is a pro-fibrogenic cytokine in the liver, but its metabolic gene signatures remain unclear to date. We have previo
Externí odkaz:
https://doaj.org/article/ab0f699f15324aba8051bcdfceea646d
Autor:
Zeribe Chike Nwosu, Dominik Andre Megger, Seddik Hammad, Barbara Sitek, Stephanie Roessler, Matthias Philip Ebert, Christoph Meyer, Steven Dooley
Publikováno v:
Cellular and Molecular Gastroenterology and Hepatology, Vol 4, Iss 2, Pp 303-323.e1 (2017)
Background & Aims: Cancer cells rely on metabolic alterations to enhance proliferation and survival. Metabolic gene alterations that repeatedly occur in liver cancer are largely unknown. We aimed to identify metabolic genes that are consistentl
Externí odkaz:
https://doaj.org/article/5f0a03e77c524741b9289eab91ce3c1f
Publikováno v:
Frontiers in Physiology, Vol 7 (2016)
Liver myofibroblasts (MFB) are crucial mediators of extracellular matrix (ECM) deposition in liver fibrosis. They arise mainly from hepatic stellate cells (HSCs) upon a process termed activation. To a lesser extent, and depending on the cause of live
Externí odkaz:
https://doaj.org/article/04c4e504a9b24ba08325f4b85cca66ae
Publikováno v:
Oncogene. 42:711-724
Publikováno v:
Molecular Cancer
Caveolin-1 (CAV1) is an oncogenic membrane protein associated with endocytosis, extracellular matrix organisation, cholesterol distribution, cell migration and signaling. Recent studies reveal that CAV1 is involved in metabolic alterations – a crit