Blocking glutamate mGlu 5 receptors with the negative allosteric modulator CTEP improves disease course in SOD1 ^G93A mouse model of amyotrophic lateral sclerosis.

Autor: Milanese M; Department of Pharmacy, Pharmacology and Toxicology Unit, University of Genoa, Genoa, Italy.; Inter-University Center for the Promotion of the 3Rs Principles in Teaching & Research (Centro 3R), Genoa, Italy., Bonifacino T; Department of Pharmacy, Pharmacology and Toxicology Unit, University of Genoa, Genoa, Italy.; Inter-University Center for the Promotion of the 3Rs Principles in Teaching & Research (Centro 3R), Genoa, Italy., Torazza C; Department of Pharmacy, Pharmacology and Toxicology Unit, University of Genoa, Genoa, Italy., Provenzano F; Department of Pharmacy, Pharmacology and Toxicology Unit, University of Genoa, Genoa, Italy.; Department of Neurodegenerative Diseases, Hertie Institute for Clinical Brain Research, University of Tübingen and German Center for Neurodegenerative Diseases (DZNE), Tübingen, Germany., Kumar M; Department of Pharmacy, Pharmacology and Toxicology Unit, University of Genoa, Genoa, Italy., Ravera S; Department of Experimental Medicine, University of Genoa, Genoa, Italy., Zerbo AR; Department of Pharmacy, Pharmacology and Toxicology Unit, University of Genoa, Genoa, Italy., Frumento G; Department of Pharmacy, Pharmacology and Toxicology Unit, University of Genoa, Genoa, Italy., Balbi M; Department of Pharmacy, Pharmacology and Toxicology Unit, University of Genoa, Genoa, Italy., Nguyen TPN; Department of Pharmacy, Pharmacology and Toxicology Unit, University of Genoa, Genoa, Italy., Bertola N; Department of Experimental Medicine, University of Genoa, Genoa, Italy., Ferrando S; Department of Earth, Environmental and Life Science, University of Genoa, Genoa, Italy., Viale M; IRCCS Ospedale policlinico San Martino, Genoa, Italy., Profumo A; IRCCS Ospedale policlinico San Martino, Genoa, Italy., Bonanno G; Department of Pharmacy, Pharmacology and Toxicology Unit, University of Genoa, Genoa, Italy.; IRCCS Ospedale policlinico San Martino, Genoa, Italy.

Publikováno v: British journal of pharmacology [Br J Pharmacol] 2021 Sep; Vol. 178 (18), pp. 3747-3764. Date of Electronic Publication: 2021 Jun 29.