Zobrazeno 1 - 10
of 43
pro vyhledávání: '"Zeran, Li"'
Autor:
Jorge L. Del-Aguila, Zeran Li, Umber Dube, Kathie A. Mihindukulasuriya, John P. Budde, Maria Victoria Fernandez, Laura Ibanez, Joseph Bradley, Fengxian Wang, Kristy Bergmann, Richard Davenport, John C. Morris, David M. Holtzman, Richard J. Perrin, Bruno A. Benitez, Joseph Dougherty, Carlos Cruchaga, Oscar Harari
Publikováno v:
Alzheimer’s Research & Therapy, Vol 11, Iss 1, Pp 1-16 (2019)
Abstract Background Alzheimer’s disease (AD) is the most common form of dementia. This neurodegenerative disorder is associated with neuronal death and gliosis heavily impacting the cerebral cortex. AD has a substantial but heterogeneous genetic co
Externí odkaz:
https://doaj.org/article/c1ad578940f34bcf889aae4a15e03c01
Autor:
Jorge L. Del-Aguila, Bruno A. Benitez, Zeran Li, Umber Dube, Kathie A. Mihindukulasuriya, John P. Budde, Fabiana H. G. Farias, Maria Victoria Fernández, Laura Ibanez, Shan Jiang, Richard J. Perrin, Nigel J. Cairns, John C. Morris, Oscar Harari, Carlos Cruchaga
Publikováno v:
Molecular Neurodegeneration, Vol 14, Iss 1, Pp 1-13 (2019)
Abstract Background Low frequency coding variants in TREM2 are associated with Alzheimer disease (AD) risk and cerebrospinal fluid (CSF) TREM2 protein levels are different between AD cases and controls. Similarly, TREM2 risk variant carriers also exh
Externí odkaz:
https://doaj.org/article/4ac1dfeaf52147c7b6a28df134a619fd
Autor:
Zeran Li, Jorge L. Del-Aguila, Umber Dube, John Budde, Rita Martinez, Kathleen Black, Qingli Xiao, Nigel J. Cairns, The Dominantly Inherited Alzheimer Network (DIAN), Joseph D. Dougherty, Jin-Moo Lee, John C. Morris, Randall J. Bateman, Celeste M. Karch, Carlos Cruchaga, Oscar Harari
Publikováno v:
Genome Medicine, Vol 10, Iss 1, Pp 1-19 (2018)
Abstract Background Alzheimer’s disease (AD) is characterized by neuronal loss and astrocytosis in the cerebral cortex. However, the specific effects that pathological mutations and coding variants associated with AD have on the cellular compositio
Externí odkaz:
https://doaj.org/article/dda71abaa386494db5ac296efd6f0e09
Autor:
Bruno A. Benitez, John P. Budde, Adam Suhy, Richard J. Perrin, Umber Dube, Brooke Sadler, Carlos Cruchaga, Zeran Li, Fengxian Wang, Brett Eiffert, Laura Ibanez, Yun Ju Sung, John C. Morris, Kathie A. Mihindukulasuriya, Oscar Harari, Chengran Yang, Joseph L. Bradley, Anne M. Fagan, Fabiana H.G. Farias, Herve Rhinn, Maria Victoria Fernandez, Jorge A. Bahena
Publikováno v:
Nature neuroscience
Understanding the tissue-specific genetic controls of protein levels is essential to uncover mechanisms of post-transcriptional gene regulation. In this study, we generated a genomic atlas of protein levels in three tissues relevant to neurological d
Autor:
Matthew J. Rosene, Simon Hsu, Shih Feng You, Logan Brase, Anthony Verbeck, Rita Martinez, Clare E. Wallace, Zeran Li, Ping Yan, Nina M. Dräger, Sydney M. Sattler, Abhirami K Iyer, Shannon L Macauley, David M. Holtzman, Bruno A. Benitez, Martin Kampmann, Carlos Cruchaga, Oscar Harari, John R. Cirrito, Jin-Moo Lee, Alison M. Goate, Celeste M. Karch
Alzheimer’s disease (AD) is characterized by the accumulation of amyloid-β (Aβ) plaques and neurofibrillary tangles in the brain. AD is also the result of complex genetic architecture that can be leveraged to understand pathways central to diseas
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::2ab76a709fc729b82f0921c920f141bf
https://doi.org/10.1101/2022.01.31.22270175
https://doi.org/10.1101/2022.01.31.22270175
Autor:
Anne M. Fagan, John P. Budde, Oscar Harari, Jorge L. Del-Aguila, Kristy Bergmann, Jen Gentsch, Fabiana H.G. Farias, Joanne Norton, Umber Dube, Zeran Li, Joseph Bradley, John C. Morris, Maria Victoria Fernandez, Fengxian Wang, Beau M. Ances, Carlos Cruchaga, Claudia Olive, Laura Ibanez, Bruno A. Benitez
Publikováno v:
J Alzheimers Dis
Background: Rare variants in PLCG2 (p.P522R), ABI3 (p.S209F), and TREM2 (p.R47H, p.R62H) have been associated with late onset Alzheimer’s disease (LOAD) risk in Caucasians. After the initial report, several studies have found positive results in co
Autor:
Fabiana H.G. Farias, Maria Victoria Fernandez, Bruno A. Benitez, Jorge L. Del-Aguila, Kathie A. Mihindukulasuriya, Umber Dube, Zeran Li, John P. Budde, Shan Jiang, John C. Morris, Carlos Cruchaga, Laura Ibanez, Richard J. Perrin, Nigel J. Cairns, Oscar Harari
Publikováno v:
Molecular Neurodegeneration, Vol 14, Iss 1, Pp 1-13 (2019)
Molecular Neurodegeneration
Molecular Neurodegeneration
Background Low frequency coding variants in TREM2 are associated with Alzheimer disease (AD) risk and cerebrospinal fluid (CSF) TREM2 protein levels are different between AD cases and controls. Similarly, TREM2 risk variant carriers also exhibit diff
Autor:
Fabiana H.G. Farias, Carlos Cruchaga, John P. Budde, Joseph Bradley, Richard Davenport, Zeran Li, Alzheimer’s Disease Neuroimaging Initiative, Yuetiva Deming, Benjamin Saef, Oscar Harari, Fengxian Wang
Publikováno v:
Alzheimer's & Dementia. 16
Autor:
Anne M. Fagan, Herve Rhinn, Fabiana H.G. Farias, Maria Victoria Fernandez, Carlos Cruchaga, Brooke Sadler, Umber Dube, Zeran Li, Fengxian Wang, John C. Morris, Yun Ju Sung, Kathie A. Mihindukulasuriya, Chengran Yang, Jorge A. Bahena, John P. Budde, Richard J. Perrin, Joseph Bradley, Bruno A. Benitez, Laura Ibanez, Oscar Harari, Brett Eiffert
Expression quantitative trait loci (eQTL) mapping has successfully resolved some genome-wide association study (GWAS) loci for complex traits1–6. However, there is a need for implementing additional “omic” approaches to untangle additional loci
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e520439169ca7123ee9b1742eaa1b71b
https://doi.org/10.1101/2020.06.25.20140277
https://doi.org/10.1101/2020.06.25.20140277
Publikováno v:
PLoS ONE, Vol 7, Iss 6, p e40132 (2012)
Phenylthiourea (PTU) is commonly used for inhibiting melanization of zebrafish embryos. In this study, the standard treatment with 0.2 mM PTU was demonstrated to specifically reduce eye size in larval fish starting at three days post-fertilization. T
Externí odkaz:
https://doaj.org/article/d3af4a64d6034bdcab05c9fb1d737786