Zobrazeno 1 - 10
of 139
pro vyhledávání: '"Zeping Hu"'
Autor:
Fang Wang, Kai Fu, Yujue Wang, Can Pan, Xueping Wang, Zeyu Liu, Chuan Yang, Ying Zheng, Xiaopeng Li, Yu Lu, Kenneth Kin Wah To, Chenglai Xia, Jianye Zhang, Zhi Shi, Zeping Hu, Min Huang, Liwu Fu
Publikováno v:
Acta Pharmaceutica Sinica B, Vol 14, Iss 3, Pp 905-952 (2024)
Cancer immunotherapy, exemplified by the remarkable clinical benefits of the immune checkpoint blockade and chimeric antigen receptor T-cell therapy, is revolutionizing cancer therapy. They induce long-term tumor regression and overall survival benef
Externí odkaz:
https://doaj.org/article/06e7be5579fb4a6c9c58d69cff3d3f9c
Autor:
Yangzi Chen, Bohong Wang, Yizi Zhao, Xinxin Shao, Mingshuo Wang, Fuhai Ma, Laishou Yang, Meng Nie, Peng Jin, Ke Yao, Haibin Song, Shenghan Lou, Hang Wang, Tianshu Yang, Yantao Tian, Peng Han, Zeping Hu
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-13 (2024)
Abstract Gastric cancer (GC) represents a significant burden of cancer-related mortality worldwide, underscoring an urgent need for the development of early detection strategies and precise postoperative interventions. However, the identification of
Externí odkaz:
https://doaj.org/article/1715309fd482489ebfe289929bc7443b
Autor:
Huanhuan Pang, Zeping Hu
Publikováno v:
Acta Pharmaceutica Sinica B, Vol 13, Iss 8, Pp 3238-3251 (2023)
Emerging evidence has demonstrated the vital role of metabolism in various diseases or disorders. Metabolomics provides a comprehensive understanding of metabolism in biological systems. With advanced analytical techniques, metabolomics exhibits unpr
Externí odkaz:
https://doaj.org/article/6e7040e49e2f46088b7d1fac07814068
Autor:
Qiyin Zhou, Wenyu Lin, Chaoqun Wang, Fei Sun, Siwei Ju, Qian Chen, Yi Wang, Yongxia Chen, Haomin Li, Linbo Wang, Zeping Hu, Hongchuan Jin, Xian Wang, Yi Sun
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-18 (2022)
Neddylation inhibition has been reported as a therapy for cancer. Here, the authors show that neddylation inhibition increases glutamine metabolism by stabilizing glutamine transporter ASCT2, therefore targeting ASCT2 improves the anti-cancer effect
Externí odkaz:
https://doaj.org/article/5b5ddbc59fa9458e98897f0c628a4628
Autor:
Yisheng Jiang, Yongqiang Deng, Huanhuan Pang, Tiantian Ma, Qing Ye, Qi Chen, Haiyang Chen, Zeping Hu, Cheng-Feng Qin, Zhiheng Xu
Publikováno v:
Cell Discovery, Vol 8, Iss 1, Pp 1-17 (2022)
Abstract The global COVID-19 epidemic has spread rapidly around the world and caused the death of more than 5 million people. It is urgent to develop effective strategies to treat COVID-19 patients. Here, we revealed that SARS-CoV-2 infection resulte
Externí odkaz:
https://doaj.org/article/7a3835df015d40f0a03de6f8a36ed636
Autor:
Xiao-Ru Ma, Xudong Zhu, Yujie Xiao, Hui-Min Gu, Shuang-Shuang Zheng, Liang Li, Fan Wang, Zhao-Jun Dong, Di-Xian Wang, Yang Wu, Chenyu Yang, Wenhong Jiang, Ke Yao, Yue Yin, Yang Zhang, Chao Peng, Lixia Gao, Zhuoxian Meng, Zeping Hu, Chong Liu, Li Li, Hou-Zao Chen, Yousheng Shu, Zhenyu Ju, Jing-Wei Zhao
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-19 (2022)
Age-dependent decline in remyelination in the CNS is associated with declined differentiation capacity of oligodendrocyte progenitor cells (OPCs). Here, the authors show nuclear entry of SIRT2 is impaired and NAD+ levels are reduced during ageing in
Externí odkaz:
https://doaj.org/article/5e54229427a044a9afccbf8998af649c
Autor:
Wenting Cheng, Huanhuan Pang, Matthew J. Campen, Jianzhong Zhang, Yanting Li, Jinling Gao, Dunqiang Ren, Xiaoya Ji, Nathaniel Rothman, Qing Lan, Yuxin Zheng, Shuguang Leng, Zeping Hu, Jinglong Tang
Publikováno v:
Particle and Fibre Toxicology, Vol 19, Iss 1, Pp 1-14 (2022)
Abstract Background Chronic exposure to diesel exhaust has a causal link to cardiovascular diseases in various environmental and occupational settings. Arterial endothelial cell function plays an important role in ensuring proper maintenance of cardi
Externí odkaz:
https://doaj.org/article/a74fe31706334d50bb71590b1409744b
Autor:
Meng Nie, Ke Yao, Xinsheng Zhu, Na Chen, Nan Xiao, Yi Wang, Bo Peng, LiAng Yao, Peng Li, Peng Zhang, Zeping Hu
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-13 (2021)
Abstract Metabolic reprogramming evolves during cancer initiation and progression. However, thorough understanding of metabolic evolution from preneoplasia to lung adenocarcinoma (LUAD) is still limited. Here, we perform large-scale targeted metabolo
Externí odkaz:
https://doaj.org/article/685206940d834c8ba795886ae2a63f49
Autor:
Meng Nie, Na Chen, Huanhuan Pang, Tao Jiang, Wei Jiang, Panwen Tian, LiAng Yao, Yangzi Chen, Ralph J. DeBerardinis, Weimin Li, Qitao Yu, Caicun Zhou, Zeping Hu
Publikováno v:
The Journal of Clinical Investigation, Vol 132, Iss 20 (2022)
Although first-line epidermal growth factor receptor (EGFR) tyrosine kinase inhibitor (TKI) therapy is effective for treating EGFR-mutant non–small cell lung cancer (NSCLC), it is now understood that drug-tolerant persister (DTP) cells escaping fro
Externí odkaz:
https://doaj.org/article/789b2156434f4f39873932a243dcf50f
Autor:
Nan Xiao, Meng Nie, Huanhuan Pang, Bohong Wang, Jieli Hu, Xiangjun Meng, Ke Li, Xiaorong Ran, Quanxin Long, Haijun Deng, Na Chen, Shao Li, Ni Tang, Ailong Huang, Zeping Hu
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-13 (2021)
Metabolism changes can modulate immune responses in many contexts, and vice versa. Here the authors associate metabolomic, as well as cytokine and chemokine, data from stratified COVID-19 patients to find that arginine, tryptophan and purine metaboli
Externí odkaz:
https://doaj.org/article/b58960adabc94fd2b285cde23e2b847e