Zobrazeno 1 - 10
of 39
pro vyhledávání: '"Zenzaburo Tozuka"'
Publikováno v:
PLoS ONE, Vol 10, Iss 7, p e0130760 (2015)
The purpose of this study was to develop quantitative liquid chromatography-tandem mass spectrometry (LC-MS/MS) methods for the analysis of proteins involved in metastasis of breast cancer for diagnosis and determining disease prognosis, as well as t
Externí odkaz:
https://doaj.org/article/6672a71ef4224f269d15e08afe4033fd
Autor:
Aya Harada Takeda, Toshiya Morie, Kentaro Jingushi, Masatatsu Yamamoto, Souta Iyama, Ikumi Ohshio, Hiroaki Hase, Shintarou Fujii, Masami Sato, Zenzaburo Tozuka, Yuko Ueda, Kazuhiro Ueda, Kazutake Tsujikawa, Shohei Sato, Kentaro Minami, Takahiro Kogaki, Daisuke Saigusa, Tatsuhiko Furukawa, Toshiyuki Nagata, Masaya Aoki, Kaori Kitae, Kohichi Kawahara, Hasumi Ura
Publikováno v:
Journal of pharmaceutical and biomedical analysis. 197
There are more than 150 types of naturally occurring modified nucleosides, which are believed to be involved in various biological processes. Recently, an ultrahigh performance liquid chromatography-electrospray ionization-tandem mass spectrometry (U
Autor:
Akihiro Kunisawa, Zenzaburo Tozuka
Publikováno v:
Trends in Research. 1
Publikováno v:
Trends in Research. 1
Autor:
Kazuya Maeda, Yoshimi Hamabe, Toshihiko Ikeda, Shinsuke Aoyama, Kohei Nozawa, Zenzaburo Tozuka, Michiko Kainuma, Setsuo Hasegawa, Takao Matsui, Yuichi Sugiyama
Publikováno v:
European Journal of Pharmaceutical Sciences. 49:642-648
Microdose study enables us to understand the pharmacokinetic profiles of drugs in humans prior to the conventional clinical trials. The advantage of microdose study is that the unexpected pharmacological/toxicological effects of drugs caused by drug
Autor:
Tomonori Takami, Zenzaburo Tozuka, Akira Yamazaki, Naoe Yamane, Yuji Kumagai, Yuichi Sugiyama
Publikováno v:
Drug Metabolism and Pharmacokinetics. 24:389-403
Summery: A sample treatment procedure and high-sensitive liquid chromatography/tandem mass spectrometry (LC/MS/MS) method for quantitative determination of nicardipine in human plasma were developed for a microdose clinical trial with nicardipine, a
Autor:
Osamu Okazaki, Kenichi Sudo, Tomonori Takami, Hiroshi Masumoto, Shohei Shioyama, Zenzaburo Tozuka, Hideo Yukinaga
Publikováno v:
Chemical Research in Toxicology. 20:1373-1378
Covalent binding of reactive metabolites to cytochrome P450s (P450s) often causes their mechanism-based inactivation (MBI), resulting in drug-drug interactions or toxicity. The detection and identification of the P450 sites to which reactive metaboli
Autor:
Rika Ishimura, Akira Kagayama, Zenzaburo Tozuka, Tomoko Hashimoto, Wolfgang Metelmann Strupat, Toshifumi Shiraga, Akio Kawamura
Publikováno v:
Journal of the Mass Spectrometry Society of Japan. 53:89-99
MS2 fragments are produced by cleavage of all protonated molecules at the lone electron pairs of heteroatoms or the π electrons of double bonds of FK228. Usually, data dependent MS3 measurement cleaves only MS2 fragment of highest intensity that nor
Autor:
Yasuyuki Mitani, Anri Aoba, Hayato Kaneko, Akira Kagayama, Zenzaburo Tozuka, Toshifumi Shiraga, Akio Kawamura
Publikováno v:
Drug Metabolism and Pharmacokinetics. 17:316-339
TSQ ESI MS/MS and ion trap ESI MS(2) cleave protonated molecules. MS(2) at m/z 332 of zotepine cleaved m/z 245 (10%), m/z 287 (5%) and m/z 315 (100%) fragment ions at protonated positions. MS(2) at m/z 356 of tiaramide cleaved m/z 338 (18%), 313 (10%
Autor:
Zenzaburo Tozuka
Publikováno v:
Journal of the Mass Spectrometry Society of Japan. 47:229-245
The quantitative analysis is the base of clinical pharmacokinetics, pharmacokinetics, toxicokinetics, and pharmacodynamics. The pretreatment is important for the quantitative analysis, because the recovery of the pretreatment for the quantitative ana