Zobrazeno 1 - 5
of 5
pro vyhledávání: '"Zenzaburo Nakata"'
Autor:
Eiichi Kojima, Atsuhiro Iimuro, Mado Nakajima, Hirotaka Kinuta, Naoya Asada, Yusuke Sako, Zenzaburo Nakata, Kentaro Uemura, Shuhei Arita, Shinobu Miki, Chiaki Wakasa-Morimoto, Yuki Tachibana
Publikováno v:
Journal of Medicinal Chemistry. 65:6157-6170
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::47f9735709be42f4cf956b8442fd112d
https://doi.org/10.1021/acs.jmedchem.1c02217
https://doi.org/10.1021/acs.jmedchem.1c02217
Autor:
Yoshifumi Kusumoto, Kyohei Hayashi, Soichiro Sato, Toru Yamada, Iori Kozono, Zenzaburo Nakata, Naoya Asada, Shungo Mitsuki, Ayahisa Watanabe, Chiaki Wakasa-Morimoto, Kentaro Uemura, Shuhei Arita, Shinobu Miki, Tohru Mizutare, Hidenori Mikamiyama
Publikováno v:
ACS medicinal chemistry letters. 13(10)
Human immunodeficiency virus type-1 (HIV-1) protease is essential for viral propagation, and its inhibitors are key anti-HIV-1 drug candidates. In this study, we discovered a novel HIV-1 protease inhibitor (compound
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ce70e02630fb12dc340f6b4e77a44913
https://pubmed.ncbi.nlm.nih.gov/36262395
https://pubmed.ncbi.nlm.nih.gov/36262395
Autor:
Eiichi, Kojima, Atsuhiro, Iimuro, Mado, Nakajima, Hirotaka, Kinuta, Naoya, Asada, Yusuke, Sako, Zenzaburo, Nakata, Kentaro, Uemura, Shuhei, Arita, Shinobu, Miki, Chiaki, Wakasa-Morimoto, Yuki, Tachibana
Publikováno v:
Journal of medicinal chemistry. 65(8)
A novel strategy for lead identification that we have dubbed the "Pocket-to-Lead" strategy is demonstrated using HIV-1 protease as a model target. Sometimes, it is difficult to obtain hit compounds because of the difficulties in satisfying the comple
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::942e8c5024d70e6d348ec85dd0eb1ca4
https://pubmed.ncbi.nlm.nih.gov/35416651
https://pubmed.ncbi.nlm.nih.gov/35416651
Autor:
Norihisa Yasui, Junichi Takagi, Hideaki Bujo, Terukazu Nogi, Zenzaburo Nakata, Masamichi Nagae
Publikováno v:
Acta Crystallographica Section F Structural Biology and Crystallization Communications. 67:129-132
Low-density lipoprotein receptor (LDLR) relative with 11 binding repeats (LR11; also known as sorLA) is genetically associated with late-onset Alzheimer's disease and is thought to be involved in neurodegenerative processes. LR11 contains a vacuolar
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bed2b49ddc12c594179277a8754f34c0
https://doi.org/10.1107/s1744309110048153
https://doi.org/10.1107/s1744309110048153
Autor:
Koichi Kato, Yu Kitago, Masamichi Nagae, Emiko Mihara, Shizuka Takagi-Niidome, Zenzaburo Nakata, Terukazu Nogi, Junichi Takagi, Maho Yagi-Utsumi
Publikováno v:
Nature structuralmolecular biology. 22(3)
SorLA is a neuronal sorting receptor considered to be a major risk factor for Alzheimer's disease. We have recently reported that it directs lysosomal targeting of nascent neurotoxic amyloid-β (Aβ) peptides by directly binding Aβ. Here, we determi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8ef9f7c5a3f0431efe546eba4f58b903
https://pubmed.ncbi.nlm.nih.gov/25643321
https://pubmed.ncbi.nlm.nih.gov/25643321