Zobrazeno 1 - 10
of 39
pro vyhledávání: '"Zenta Tsuchihashi"'
Autor:
Ansh Kapil, Andreas Spitzmüller, Nicolas Brieu, Susanne Haneder, Anatoliy Shumilov, Armin Meier, Fabiola Cecchi, Alice Barkell, Nathalie Harder, Katrin Mittermaier, Ana Hidalgo-Sastre, Regina Alleze, Markus Schick, Günter Schmidt, Hadassah Sade, Zenta Tsuchihashi, Fumitaka Suto, Mark Gustavson, J. Carl Barrett, Danielle Carroll
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-14 (2024)
Abstract Many targeted cancer therapies rely on biomarkers assessed by scoring of immunohistochemically (IHC)-stained tissue, which is subjective, semiquantitative, and does not account for expression heterogeneity. We describe an image analysis-base
Externí odkaz:
https://doaj.org/article/b0bb13ca3be44be6a20f420d905211e6
Autor:
Jeanne Mendell, Daniel J. Freeman, Wenqin Feng, Thore Hettmann, Matthias Schneider, Sabine Blum, Jens Ruhe, Johannes Bange, Kenji Nakamaru, Shuquan Chen, Zenta Tsuchihashi, Joachim von Pawel, Catherine Copigneaux, Robert A. Beckman
Publikováno v:
EBioMedicine, Vol 2, Iss 3, Pp 264-271 (2015)
Background: During early clinical development, prospective identification of a predictive biomarker and validation of an assay method may not always be feasible. Dichotomizing a continuous biomarker measure to classify responders also leads to challe
Externí odkaz:
https://doaj.org/article/7234004e5d4f47c7ab14202b186df656
Autor:
Matt D. Galsky, Gianluca Del Conte, Silvia Foti, Evan Y. Yu, Jean-Pascal H. Machiels, Bernard Doger, Andrea Necchi, Filippo G. De Braud, Erika P. Hamilton, Audrey Hennequin, Tom Van den Mooter, Philip R. Debruyne, Irene Moreno, Hendrik-Tobias Arkenau, Zenta Tsuchihashi, Fu-Chih Cheng, Bincy Augustine, Ben Cheng, Daniel Barrios, Diana Lüftner
Publikováno v:
Journal of Clinical Oncology. 40:438-438
438 Background: HER2 overexpression has been found in invasive UC, suggesting a role for HER2 in disease progression and prognosis (Kruger Int J Oncol 2002). T-DXd is an antibody-drug conjugate comprising an anti-HER2 antibody, a cleavable linker, an
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::67b204f76354931f4e845542fa7b70ed
https://doi.org/10.1200/jco.2022.40.6_suppl.438
https://doi.org/10.1200/jco.2022.40.6_suppl.438
Autor:
Kenji Nakamaru, Daniel J. Freeman, Catherine Copigneaux, Jens Ruhe, Johannes Bange, Thore Hettmann, Jeanne Mendell, Joachim von Pawel, Sabine Blum, Matthias Schneider, Zenta Tsuchihashi, Robert A. Beckman, Wenqin Feng, Shuquan Chen
Publikováno v:
EBioMedicine, Vol 2, Iss 3, Pp 264-271 (2015)
EBioMedicine
EBioMedicine
Background During early clinical development, prospective identification of a predictive biomarker and validation of an assay method may not always be feasible. Dichotomizing a continuous biomarker measure to classify responders also leads to challen
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4788bf0216a6cbe316403902a891f1db
https://doi.org/10.1016/j.ebiom.2015.02.005
https://doi.org/10.1016/j.ebiom.2015.02.005
Autor:
Marlene A. Bunni, Brian J. Siroky, Bradley P. Dixon, P. Darwin Bell, John J. Bissler, Zenta Tsuchihashi, Joshua C. Dillon, Ryan J. Reichert, Thiruvamoor Ramkumar, Anna R. Hellmann, Julian R. Sampson, Hong Yin
Publikováno v:
American Journal of Physiology-Renal Physiology. 307:F560-F570
Nearly all patients with tuberous sclerosis complex (TSC) develop renal angiomyolipomas, although the tumor cell of origin is unknown. We observed decreased renal angiomyolipoma development in patients with TSC2- polycystic kidney disease 1 deletion
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::81b047852f98e84d58a1c3674661c5f7
https://doi.org/10.1152/ajprenal.00569.2013
https://doi.org/10.1152/ajprenal.00569.2013
Autor:
Brian B Spear, Zenta Tsuchihashi, Lois Hinman, Francis Kalush, Federico Goodsaid, James F. Kelly, Peter F. Bross
Publikováno v:
Pharmacogenomics. 10:127-136
The 4th US FDA/Industry Workshop on Pharmacogenomics in Drug Development and Regulatory Decision Making, was held in MD, USA, on December 10–12, 2007. One of the breakout sessions of the workshop focused on the regulatory issues around codevelopmen
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::6fc93b62b0714eaec106c0fde3f8d20e
https://doi.org/10.2217/14622416.10.1.127
https://doi.org/10.2217/14622416.10.1.127
Autor:
Beow Y. Yeap, Lewis C. Cantley, Toru Mukohara, Neal I. Lindeman, Susumu Kobayashi, Pasi A. Jänne, Joseph Pearlberg, Daniel G. Tenen, Bruce E. Johnson, Jeffrey A. Engelman, Zenta Tsuchihashi, Balazs Halmos, N.H. Hanna
Publikováno v:
JNCI: Journal of the National Cancer Institute. 97:1185-1194
BACKGROUND Many patients with non-small-cell lung cancer (NSCLC) who achieve radiographic responses to treatment with the epidermal growth factor receptor (EGFR) tyrosine kinase inhibitors gefitinib and erlotinib have somatic mutations in the EGFR ty
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9b74b9139cfab5f526bf41c3c92574a6
https://doi.org/10.1093/jnci/dji238
https://doi.org/10.1093/jnci/dji238
Autor:
Rene Belder, Frank M. Sacks, Shu-Pang Huang, John J.P. Kastelein, Aeilko H. Zwinderman, Todd G. Kirchgessner, Anke H.E.M. Klerkx, Greetje J. de Grooth, Beihong Hu, Zenta Tsuchihashi, Priya Sudarshan Vishnupad, Kim E. Zerba, J. Wouter Jukema, Jan Albert Kuivenhoven
Publikováno v:
Journal of the American College of Cardiology. 43:854-857
OBJECTIVES On the basis of quantitative coronary angiography data, the cholesteryl ester transfer protein (CETP) TaqIB gene polymorphism has been postulated to predict the progression of coronary atherosclerosis and response to cholesterol-lowering t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::222c1f4145cc7149ec7f6befa1230cd5
https://doi.org/10.1016/j.jacc.2003.08.056
https://doi.org/10.1016/j.jacc.2003.08.056
Autor:
Pamela J. Bjorkman, José A. Lebrón, David Penny, Randall C. Schatzman, Vince K. Lee, Elliott Sigal, Nicole Watson, Alivelu Irrinki, Zenta Tsuchihashi, John N. Feder
Publikováno v:
Proceedings of the National Academy of Sciences. 95:1472-1477
We recently reported the positional cloning of a candidate gene for hereditary hemochromatosis called HFE . The gene product, a member of the major histocompatibility complex class I-like family, was found to have a mutation, Cys-282 → Tyr (C282Y),
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b5785644c9fdb364becd1486badcdcb6
https://doi.org/10.1073/pnas.95.4.1472
https://doi.org/10.1073/pnas.95.4.1472
Publikováno v:
Nucleic Acids Research. 25:4079-4084
ATP hydrolysis is required for transcriptional initiation by RNA polymerase II in vitro. Reconstituted transcription using purified initiation factors and RNA polymerase II have revealed that the step dependent on ATP hydrolysis occurs at the same ti
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8e2f7fa5986339ef733cc11576370ad7
https://doi.org/10.1093/nar/25.20.4079
https://doi.org/10.1093/nar/25.20.4079