Zobrazeno 1 - 10
of 37
pro vyhledávání: '"Zenon Toprakcioglu"'
Autor:
Owen M. Morris, Zenon Toprakcioglu, Alexander Röntgen, Mariana Cali, Tuomas P. J. Knowles, Michele Vendruscolo
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-10 (2024)
Abstract The deposition of the amyloid-β (Aβ) peptide into amyloid fibrils is a hallmark of Alzheimer’s disease. Recently, it has been reported that some proteins can aggregate and form amyloids through an intermediate pathway involving a liquid-
Externí odkaz:
https://doaj.org/article/276ba35f259e4d73820c90e975f582ef
Autor:
Samuel T. Dada, Zenon Toprakcioglu, Mariana P. Cali, Alexander Röntgen, Maarten C. Hardenberg, Owen M. Morris, Lena K. Mrugalla, Tuomas P. J. Knowles, Michele Vendruscolo
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-13 (2024)
Abstract Aggregated forms of α-synuclein constitute the major component of Lewy bodies, the proteinaceous aggregates characteristic of Parkinson’s disease. Emerging evidence suggests that α-synuclein aggregation may occur within liquid condensate
Externí odkaz:
https://doaj.org/article/a17360268c2c42ac8264f7fd9ce9115e
Autor:
Hongjia Zhu, Lianne W.Y. Roode, Aled J. Parry, Nadia A. Erkamp, Marc Rodriguez-Garcia, Masako Narita, Yi Shen, Yangteng Ou, Zenon Toprakcioglu, Masashi Narita, Tuomas P.J. Knowles
Publikováno v:
Advanced NanoBiomed Research, Vol 2, Iss 12, Pp n/a-n/a (2022)
Multicellular cancer spheroids (MCSs) have emerged as a promising in vitro model that recaptures many features of solid tumours in vivo. To generate cancer spheroids, cells are encapsulated in microgels with high throughput. While the biophysical pro
Externí odkaz:
https://doaj.org/article/369ea35e844a417f8d8542434b7c0f1a
Publikováno v:
Microsystems & Nanoengineering, Vol 7, Iss 1, Pp 1-10 (2021)
Abstract Droplet microfluidic methods have opened up the possibility of studying a plethora of phenomena ranging from biological to physical or chemical processes at ultra low volumes and high throughput. A key component of such approaches is the abi
Externí odkaz:
https://doaj.org/article/ffd7bcbb428a4cf884adf534e3df0a44
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-10 (2021)
Abstract Microcapsules and microgels consisting of macromolecular networks have received increasing attention due to their biomedical and pharmaceutical applications. Protein microgels and in particular silk-based microcapsules have desirable propert
Externí odkaz:
https://doaj.org/article/80242fab8890429c8f7d34bf7ef913df
Autor:
Georg Krainer, Timothy J. Welsh, Jerelle A. Joseph, Jorge R. Espinosa, Sina Wittmann, Ella de Csilléry, Akshay Sridhar, Zenon Toprakcioglu, Giedre Gudiškytė, Magdalena A. Czekalska, William E. Arter, Jordina Guillén-Boixet, Titus M. Franzmann, Seema Qamar, Peter St George-Hyslop, Anthony A. Hyman, Rosana Collepardo-Guevara, Simon Alberti, Tuomas P. J. Knowles
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-14 (2021)
Elucidating the molecular driving forces underlying liquid–liquid phase separation is a key objective for understanding biological function and malfunction. Here the authors show that a wide range of cellular proteins, including FUS, TDP-43, Brd4,
Externí odkaz:
https://doaj.org/article/f1a7c13511ed46d3b7d48b9f4017a81c
Autor:
Samuel T. Dada, Maarten C. Hardenberg, Zenon Toprakcioglu, Lena K. Mrugalla, Mariana P. Cali, Mollie O. McKeon, Ewa Klimont, Thomas C. T. Michaels, Tuomas P. J. Knowles, Michele Vendruscolo
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America, 120 (9)
The aggregation of α-synuclein into amyloid fibrils has been under scrutiny in recent years because of its association with Parkinson's disease. This process can be triggered by a lipid-dependent nucleation process, and the resulting aggregates can
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::94be8c81cd6876b2174cbff451e217ee
Autor:
Oliver Vanderpoorten, Ali N. Babar, Georg Krainer, Raphaël P. B. Jacquat, Pavan K. Challa, Quentin Peter, Zenon Toprakcioglu, Catherine K. Xu, Ulrich F. Keyser, Jeremy J. Baumberg, Clemens F. Kaminski, Tuomas P. J. Knowles
Publikováno v:
ACS Applied Nano Materials. 5:1995-2005
Autor:
Alyssa Miller, Sean Chia, Zenon Toprakcioglu, Tuuli Hakala, Roman Schmid, Yaduo Feng, Tadas Kartanas, Ayaka Kamada, Michele Vendruscolo, Francesco Simone Ruggeri, Tuomas P. J. Knowles
Publikováno v:
Science Advances, 9(2)
Science Advances 9 (2023) 2
Science Advances 9 (2023) 2
Fundamental knowledge of the physical and chemical properties of biomolecules is key to understanding molecular processes in health and disease. Bulk and single-molecule analytical methods provide rich information about biomolecules but often require
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::32eeafeaf855daf808dfae7c946c8a48
https://research.wur.nl/en/publications/enhanced-surface-nanoanalytics-of-transient-biomolecular-processe
https://research.wur.nl/en/publications/enhanced-surface-nanoanalytics-of-transient-biomolecular-processe
Autor:
Zenon Toprakcioglu, Elizabeth G. Wiita, Akhila K. Jayaram, Rebecca C. Gregory, Tuomas P. J. Knowles
The rapid emergence of drug-resistant bacteria and fungi poses a threat for healthcare worldwide. The development of novel effective small molecule therapeutic strategies in this space has remained challenging. An orthogonal approach, therefore, is t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::23e83aaea45790ac97a68fd551580f29
https://doi.org/10.1101/2022.12.18.520325
https://doi.org/10.1101/2022.12.18.520325