Zobrazeno 1 - 10
of 25
pro vyhledávání: '"Zenon D. Konteatis"'
Autor:
Joshua Murtie, Anil K. Padyana, Lei Jin, Marc L. Hyer, Zhixiao Liu, Scott A. Biller, Jeremy Travins, Amelia Barnett, Katya Marjon, Brandon Nicolay, Wentao Wei, Raj Nagaraja, Cheng Fang, Yi Gao, Yabo Sun, Ye Zhixiong, Fan Jiang, Peter Kalev, Stefan Gross, Zenon D. Konteatis, Byron DeLaBarre, Zhihua Sui, Kevin Marks, Lenny Dang, Jie Yu, Everton Mandley, Yue Chen
Publikováno v:
Journal of Medicinal Chemistry. 64:4430-4449
The metabolic enzyme methionine adenosyltransferase 2A (MAT2A) was recently implicated as a synthetic lethal target in cancers with deletion of the methylthioadenosine phosphorylase (MTAP) gene, which is adjacent to the CDKN2A tumor suppressor and co
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::97283e129d6853ac6b9ff735db2724ec
https://doi.org/10.1021/acs.jmedchem.0c01895
https://doi.org/10.1021/acs.jmedchem.0c01895
Autor:
Zenon D. Konteatis, Zhihua Sui
Publikováno v:
Successful Drug Discovery
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::85cbcdc931bb6badd3781d1c54b46155
https://doi.org/10.1002/9783527826872.ch8
https://doi.org/10.1002/9783527826872.ch8
Autor:
Brandon Nicolay, Ingo K. Mellinghoff, Paolo Codega, Hua Yang, Zenon D. Konteatis, Janeta Popovici-Muller, Katharine E. Yen, Rohini Narayaraswamy, Raj Nagaraja, Zhihua Sui, Shinsan M. Su, Erin Artin, Kimberly Straley, Zhenwei Cai, Feng Wang, Shuilong Tong, Lei Jin, Yue Chen, Cui Dawei, Carl Campos, Zhiyong Luo, Cheng Fang, Xiaobing Lv, Lenny Dang, Ding Zhou, Anil K. Padyana, Huachun Tang, Scott A. Biller
Publikováno v:
ACS Medicinal Chemistry Letters
Inhibitors of mutant isocitrate dehydrogenase (mIDH) 1 and 2 cancer-associated enzymes prevent the accumulation of the oncometabolite d-2-hydroxyglutarate (2-HG) and are under clinical investigation for the treatment of several cancers harboring an I
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::43b32007fc702636fdd2a4b9ade51afa
https://doi.org/10.1021/acsmedchemlett.9b00509
https://doi.org/10.1021/acsmedchemlett.9b00509
Autor:
Zenon D. Konteatis
Publikováno v:
Expert opinion on drug discovery. 16(7)
Over the past 25 years, fragment-based drug discovery (FBDD) has emerged as a highly successful, complementary approach to high-throughput screening (HTS) to identify quality leads for optimization...
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0b219e92856fdc03310aa025a53e07d3
https://pubmed.ncbi.nlm.nih.gov/33769176
https://pubmed.ncbi.nlm.nih.gov/33769176
Autor:
Sung Choe, Zenon D. Konteatis, Chris Bowden, Brandon Nicolay, Courtney D. DiNardo, Bin Wu, Jessica K. Altman, Alice S. Mims, Lenny Dang, Scott A. Biller, Guowen Liu, Daniel A. Pollyea, Parham Nejad, Hongfang Wang, Eyal C. Attar, Richard Stone, Stéphane de Botton, Wei Liu, Vickie Zhang, Eytan M. Stein, Kevin Marks, Justin M. Watts, Gail J. Roboz, Meredith Goldwasser, Lynn Quek, Amir T. Fathi, Hua Liu, Hagop M. Kantarjian, Martin S. Tallman
Publikováno v:
Blood Adv
Isocitrate dehydrogenase (IDH) 1 and 2 mutations result in overproduction of D-2-hydroxyglutarate (2-HG) and impaired cellular differentiation. Ivosidenib, a targeted mutant IDH1 (mIDH1) enzyme inhibitor, can restore normal differentiation and result
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1347f230d6dba15f0b28ec89e6347cc4
https://pubmed.ncbi.nlm.nih.gov/32380538
https://pubmed.ncbi.nlm.nih.gov/32380538
Publikováno v:
Medicinal Chemistry Reviews ISBN: 9780996293280
Medicinal Chemistry Reviews
Medicinal Chemistry Reviews
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::aa38ca629120b103c6de331269ecbabd
https://doi.org/10.29200/acsmedchemrev-v54.ch7
https://doi.org/10.29200/acsmedchemrev-v54.ch7
Autor:
Justin Taylor, Fabian Correa, Craig B. Thompson, Bo Wang, Gregory A. Petsko, Zenon D. Konteatis, Noushin Farnoud, Maria E. Arcila, Bin Wu, Ariën S. Rustenburg, Sung Choe, Mikhail Roshal, Naofumi Takemoto, Ross L. Levine, Vidushi Durani, Andrew M. Intlekofer, Steven K. Albanese, Hui Liu, Christopher Famulare, Eytan M. Stein, Scott A. Biller, Elli Papaemmanuil, Minal Patel, Justin R. Cross, Abbas Nazir, Martin S. Tallman, Alan H. Shih, John D. Chodera
Publikováno v:
Nature
Somatic mutations in the isocitrate dehydrogenase 2 gene (IDH2) contribute to the pathogenesis of acute myeloid leukaemia (AML) through the production of the oncometabolite 2-hydroxyglutarate (2HG)1–8. Enasidenib (AG-221) is an allosteric inhibitor
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5755791ce937d711d3a623bbe5c5e1c5
https://doi.org/10.1038/s41586-018-0251-7
https://doi.org/10.1038/s41586-018-0251-7
AG-221, a First-in-Class Therapy Targeting Acute Myeloid Leukemia Harboring Oncogenic IDH2 Mutations
Autor:
Olivia Bawa, Monika Pilichowska, Paule Opolon, Jeffrey O. Saunders, Fang Wang, Cyril Quivoron, Anil K. Padyana, Zenon D. Konteatis, Kimberly Straley, Erica Tobin, Sophie Broutin, Marion Dorsch, Hua Yang, Byron DeLaBarre, Jeremy Travins, Sung Choe, Yue Chen, Lei Jin, Wentao Wei, Virginie Penard-Lacronique, Raj Nagaraja, Wei Liu, Lenny Dang, Shengfang Jin, Cheng Fang, Lee Silverman, Fan Jiang, Katharine E. Yen, Giovanni Cianchetta, Olivier Bernard, Erin Artin, Muriel D. David, Shin-San Michael Su, Stefan Gross, Francesco G. Salituro, Véronique Saada, Stéphane de Botton, Scott A. Biller, Angelo Paci, Benoit S. Marteyn, Yingxia Xu
Publikováno v:
Cancer Discovery
Cancer Discovery, American Association for Cancer Research, 2017, 7 (5), pp.478-493. ⟨10.1158/2159-8290.CD-16-1034⟩
Cancer Discovery, American Association for Cancer Research, 2017, 7 (5), pp.478-493. ⟨10.1158/2159-8290.CD-16-1034⟩
Somatic gain-of-function mutations in isocitrate dehydrogenases (IDH) 1 and 2 are found in multiple hematologic and solid tumors, leading to accumulation of the oncometabolite (R)-2-hydroxyglutarate (2HG). 2HG competitively inhibits α-ketoglutarate
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6e5319b71d47ef568ebb071e758566cc
https://doi.org/10.1158/2159-8290.cd-16-1034
https://doi.org/10.1158/2159-8290.cd-16-1034
Autor:
Zhihua Sui, Zenon D. Konteatis
Publikováno v:
2018 Medicinal Chemistry Reviews ISBN: 9780996293266
2018 Medicinal Chemistry Reviews
2018 Medicinal Chemistry Reviews
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::81c8f51d644ab1b349d9c038e4647b4f
https://doi.org/10.29200/acsmedchemrev-v53.ch26
https://doi.org/10.29200/acsmedchemrev-v53.ch26
Autor:
Rachel Peters, Kate Lizotte, Victoria Frank, Yesim Tuncay, Katie Sellers, Elia Aguado-Fraile, Marc L. Hyer, Everton Mandley, Scott A. Biller, Michelle Clasquin, Katya Marjon, Phong Quang, Jeremy Travins, Joshua E. Goldford, Zenon D. Konteatis, Chi-Chao Chen, Jaclyn Weier, Lenny Dang, Raj Nagaraja, Peter Kalev, Kevin Marks, Wei Liu, Eric Simone, Joshua Murtie, Stefan Gross, Max Lein, Yue Chen, Mark Fletcher, Amelia Barnett, Zhihua Sui, Sebastian Hayes
Publikováno v:
Cancer Cell. 39:209-224.e11
The methylthioadenosine phosphorylase (MTAP) gene is located adjacent to the cyclin-dependent kinase inhibitor 2A (CDKN2A) tumor-suppressor gene and is co-deleted with CDKN2A in approximately 15% of all cancers. This co-deletion leads to aggressive t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0321c4d9d9fb5c7eb5dbd4d4870244aa
https://doi.org/10.1016/j.ccell.2020.12.010
https://doi.org/10.1016/j.ccell.2020.12.010