Adaptation of Plasmodium falciparum to humans involved the loss of an ape-specific erythrocyte invasion ligand

Autor: William R. Proto, Sasha V. Siegel, Selasi Dankwa, Weimin Liu, Alison Kemp, Sarah Marsden, Zenon A. Zenonos, Steve Unwin, Paul M. Sharp, Gavin J. Wright, Beatrice H. Hahn, Manoj T. Duraisingh, Julian C. Rayner

Publikováno v: Nature Communications, Vol 10, Iss 1, Pp 1-12 (2019)

Here, Proto et al. show that human infective Plasmodium falciparum isolates contain an inactivating mutation in the erythrocyte invasion associated gene PfEBA165, while homologues of ape-infective Laverania species are intact, and that expression of

Externí odkaz: https://doaj.org/article/bd6dae0de5d54fc5a18cf05d76370dba

Epistasis studies reveal redundancy among calcium-dependent protein kinases in motility and invasion of malaria parasites

Autor: Hanwei Fang, Ana Rita Gomes, Natacha Klages, Paco Pino, Bohumil Maco, Eloise M. Walker, Zenon A. Zenonos, Fiona Angrisano, Jake Baum, Christian Doerig, David A. Baker, Oliver Billker, Mathieu Brochet

Publikováno v: Nature Communications, Vol 9, Iss 1, Pp 1-14 (2018)

Despite functional optimisation during evolution of parasitism, most members of a calcium dependent protein kinase (CDPK) family show genetic redundancy in Plasmodium. Here, the authors screen 294 genetic interactions among protein kinases in Plasmod

Externí odkaz: https://doaj.org/article/b4242e5263e94042a437c38f5c8a5325

Adaptation of Plasmodium falciparum to humans involved the loss of an ape-specific erythrocyte invasion ligand

Autor: Manoj T. Duraisingh, Alison Kemp, Julian C. Rayner, Selasi Dankwa, William R. Proto, Paul M. Sharp, Gavin J. Wright, Zenon A. Zenonos, Steve Unwin, Weimin Liu, Sasha V. Siegel, Sarah Marsden, Beatrice H. Hahn

Publikováno v: Nature Communications, Vol 10, Iss 1, Pp 1-12 (2019)
Nature Communications
Proto, W R, Siegel, S V, Dankwa, S, Liu, W, Kemp, A, Marsden, S, Zenonos, Z A, Unwin, S, Sharp, P M, Wright, G J, Hahn, B H, Duraisingh, M T & Rayner, J C 2019, ' Adaptation of Plasmodium falciparum to humans involved the loss of an ape-specific erythrocyte invasion ligand ', Nature Communications, vol. 10, 4512 . https://doi.org/10.1038/s41467-019-12294-3

Plasmodium species are frequently host-specific, but little is currently known about the molecular factors restricting host switching. This is particularly relevant for P. falciparum, the only known human-infective species of the Laverania sub-genus,

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d3fceb976e82c3be8b6a3b1ae92873a3
https://doaj.org/article/bd6dae0de5d54fc5a18cf05d76370dba

Malaria Vaccine Development: Focusing Field Erythrocyte Invasion Studies on Phenotypic Diversity

Autor: Julian C. Rayner, David J. Conway, Mahamadou Diakite, Ambroise D. Ahouidi, Gordon A. Awandare, Zenon A. Zenonos, Alfred Amambua-Ngwa, Manoj T. Duraisingh, Amy K. Bei

Publikováno v: Trends in Parasitology. 32:274-283

Erythrocyte invasion by Plasmodium falciparum merozoites is an essential step for parasite survival and proliferation. Invasion is mediated by multiple ligands, which could be promising vaccine targets. The usage and sequence of these ligands differs

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::b8f1bb837085e59d040af75536dd3a95
https://doi.org/10.1016/j.pt.2015.11.009

Malaria Vaccine Development: Focusing Field Erythrocyte Invasion Studies on Phenotypic Diversity: The West African Merozoite Invasion Network (WAMIN)

Autor: Ambroise D, Ahouidi, Alfred, Amambua-Ngwa, Gordon A, Awandare, Amy K, Bei, David J, Conway, Mahamadou, Diakite, Manoj T, Duraisingh, Julian C, Rayner, Zenon A, Zenonos

Publikováno v: Trends in parasitology. 32(4)

Erythrocyte invasion by Plasmodium falciparum merozoites is an essential step for parasite survival and proliferation. Invasion is mediated by multiple ligands, which could be promising vaccine targets. The usage and sequence of these ligands differs

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::fb4df8aa3e518c024dcdf897f80b1c69
https://pubmed.ncbi.nlm.nih.gov/26725306